CPPS 304 Post Mid-Final

What are two ways to overcome an infection with drug therapy? (List format) - Answer- 1. Bactericidal 2. Bacteriostatic What is chemotherapy? - Answer- Treatment of disease by chemicals (drugs) that have a specific toxic effect upon disease producing microorganisms, or that selectively destroy cancerous tissue What are the key targets of antibiotics? - Answer- Cell wall, ribosomes, DNA/RNA What are the most important drugs by class? - Answer- Beta-lactams What are bacteria cell walls made of? - Answer- peptidoglycan What is the first step in construction of a bacterial cell wall? - Answer- construction of peptidoglycan What is the second step in construction of a bacterial cell wall? - Answer- Transport of PG to outer cell membrane What is the third step in construction of a bacterial cell wall? - Answer- Linking of PG end to end to form a row What is the fourth step in construction of a bacterial cell wall? - Answer- Joining of PG rows to form a stable row What is - Answer- What is the most common form of Penicillin? - Answer- Amoxicillin What is the most effective group of antibiotics? - Answer- cell wall synthesis inhibitors Why are cell wall synthesis inhibitors so successful? - Answer- selective toxicity Do we need more antibiotics currently for Gram - or Gram +? - Answer- Gram - What PK property would a drug need in order to cross into the CNS? - Answer- Lipophilicity What do Fungi have in their cell membrane instead of cholesterol? - Answer- Ergosterol What do azole antifungals inhibit? - Answer- CYP450 enzymes