8 hr waiver training Questions With Complete Solutions

opioid mu receptor agonist drug effects: acute correct answer: euphoria, N&V, depressed respiration, sedation, analgesia, pruritus, miosis opioid mu receptor agonist drug effects: large dose acute correct answer: non-responsive, pinpoint pupils, anoxia/dilated pupils, bradycardia & hypotension, cyanotic, flacidity, pulm edema, slow or absent respiration opioid mu receptor agonist drug effects: chronic correct answer: dependence, withdrawal, tolerance, lethargy, constipation how does opioids cause constipation correct answer: mu receptors in bowels, binding to mu receptors cause slowing of peristalsis how does opioid cause respiratory depression correct answer: depression of medullary respiratory center, decreased tidal volume and minute ventilation, dec respiratory response to elevated CO2, hypercapnea,/hypoxia/dec O2 sat (sedation occurs before significant respiratory depression so it's a warning sign to look out for) opioid characteristics that increase euphoria correct answer: 1. route of administration (smoking -- IV -- SQ -- oral/intranasal) 2. half-life (fentanyl -- heroin -- methadone) 3. lipophilicity faster, shorter half-life, higher lipophilicity has higher risk of misuse