MLT ASCP Chemistry Practice Questions with correct answers
Which one of the following statements about acetaminophen metabolism is false? Choose the single best answer A. It is metabolized in the kidney B. It is largely metabolized in the liver to glucuronide and sulfonate conjugates C. A small amount is metabolized via cytochrome oxidase to a reactive benzoquinoneimine intermediate D. This intermediate becomes toxic to the liver once tissue glutathione becomes depleted CORRECT ANSWER A; The benzoquinoneimine intermediate produced in the liver as a result of hepatic cytochrome oxidase metabolism of acetaminophen is responsible for hepatic necrosis via acylation of hepatic tissue. The treatment of acetaminophen toxicity includes the use of N-acetylcysteine (Mucomyst), which acts as a glutathione substitute. The risk of hepatotoxicity is predicted with the Rumack-Matthew nomogram, which uses the hours after ingestion and plasma acetaminophen level to predict the probability of hepatotoxicity. Severe hepatotoxicity can be fatal. According to the 2010 ADA guidelines, HbA1C percent can be used as an assay to diagnose diabetes. True/False CORRECT ANSWER T; The 2010 ADA Clinical Practice Recommendations added measurement of HbA1C as a diagnostic assay for diagnosis of diabetes. Which of the following conditions would make a sample unsuitable for lactic acid testing? Choose the single best answer
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- Subido en
- 28 de febrero de 2023
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- 2022/2023
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