Walden 6630 Psychopharmacology Midterm Study Guide (A+ Graded)

Serotonin regulates correct answers Mood, emotion, feeding, and reproductive behavior This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors correct answers SSRIs First line therapy for MDD due to milder side effect profiles correct answers SSRIs Six Common SSRIs correct answers citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine Onset of therapeutic benefit from SSRIs correct answers 4-6 weeks In addition to MDD, SSRIs also treat correct answers Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia) Five Common side effects of SSRIs include correct answers Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH Severe side effect of SSRIs in children/adolescents under age 25 years old correct answers suicidal ideation Life threatening adverse effect of SSRIs, especially when used in combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) correct answers Serotonin Syndrome Excess accumulation of serotonin resulting in overstimulation of the nervous system correct answers Serotonin Syndrome Seven symptoms of Serotonin Syndrome correct answers Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia The treatment for serotonin syndrome correct answers Cyproheptadine (5-HT2 receptor antagonist) Cyproheptadine treats serotonin syndrome by correct answers blocking 5-HT2 receptors (serotonin antagonist) When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include correct answers Irritability, headaches, and insomnia Medicine specific side effect of citalopram correct answers Prolonged QT interval (normal=0.4.-0.44 seconds)