OTH 509: Final Exam

OTH 509: Final Exam Neuropathology of Alzheimer's Disease Beta amyloid plaques and tau-based neurofibrillary tangles (NFTs) Over the past several years tauopathy (NFTs) have been found to be most robust predictors of clinical syndrome Additionally, recent research has also found problematic inflammation and immune-related issues in AD Typically pathology starts in medial temporal lobe and progresses laterally, posteriorly, and anteriorly Retrograde amnesia (RA) loss of memories from our past Anterograde amnesia (AA) an inability to form new memories Alzheimer's disease (AD) ELEVATED levels of depression & anxiety behavioral dysregulation inability to store new information has insidious onset/slow build up over time Risk factors for Alzheimers older age female lower education APOE-4 status history of TBI History of mental illness history of ETOH abuse T or F: Alzheimer's is the most common form of dementia. True Typical age of onset of Alzheimer's 70-75 years old Risk factors for Lewi-body dementia age men family history Lewi-body dementia age of onset mid-50s to late 60s Lewy Body Dementia (LBD) presents as fluctuating cognition with pronounced variation in attention and alertness recurrent visual hallucinations REM sleep behavior disorder More spontaneous cardinal features of Parkinsonism (bradykinesia, rest tremor, rigidity) What are the 3 types of frontotemporal dementia?