PHARM FINAL STUDY GUIDE

75 multiple choice questions BRING A CALCULATOR (not a cell phone) How do the elements of pharmacokinetics impact drug administration and utility? Absorption, Distribution, metabolism, and excretion Why are medications given by different routes? What are the potential advantages and disadvantages of these routes? 1. Pharmacokinetics focuses on what the body does to drugs after they are administered a. Stomach—portal vein—liver—circulation—target tissue—target cell 2. Drugs use diffusion and active transport to cross plasma membranes to reach their target cells a. Diffusion: movement of chemical from higher to lower concentration (blood to tissues) 3. Absorption is the process of moving a drug from the site of administration to the bloodstream a. Absorption: the 1st step to reaching target cells; move from administration to blood; determines onset/intensity of drug action and higher absorption rates produce a more effective response b. Enteral route: delivered to GI tract either orally or through naso/gastro tubes; oral mucosa, small intestine, and stomach absorption; intended for general