NSG 6005 - Week 7 Test Study Guide. Complete Solutions Provided.

NSG 6005 - Week 7 Test Study Guide. Complete Solutions Provided. Nsg 6005 Week 7 Test STUDY GUIDE Chapter 16 1. ACEI/ ARBs - drug of choice for pt who are younger and white and patients with DM, HF, MI, CAD, heart failure with or without left ventricular dysfunction not as effective for Black patients - Bradykin in ACEI causes cough/ ARBS don’t cause cough - Improve insulin sensitivity / Helps prevent diabetic neuropathy or slow its progression - Excreted in kidneys - Absolute contraindications bilateral renal artery stenosis, pregnancy, angioedema - Catopril- take on empty stomach - Losartan- take without regard to food - Enalapril, quinapril and ramipril- can cause photosensitivity reactions - Losartan levels are lowered by inhibitors of p450 (cyp450) 3a4, and 2cp (ex. Cimetidine) - - All ARBs- interact with antacids,NSAIDS, allopurinol, rifampin, fluconazole, cimetidine, digoxin probenecid - ADR: angioedema, renal dysfunction - Dose reduce ACEI if serum CR greater than 2.5 / DC if neutrophil count is 1,000 - Check CR, WBC, and POTASSIUM levels 2. CALCIUM CHANNEL BLOCKERS - Indications: HTN, angina, tachyarrhythmias - Avoid in heart failure / EF 40% - Block calcium from entering the cell - Dihydropyridines- cause peripheral edema (nifedipine, nicardipine, amlodipine) - Interact with CYP 3A4 - Antihypertensive effects may be decreased with use of NSAIDS - Digoxin levels may be increased - Verapamil may be decreased with use of VIT d and calcium / also use with statin HMG-Co-A reductase inhibitor serum levels may be increased - Avoid grapefruit juice/ high fat meals - All CCB’s- interact with H2 blockers - Diltiazem (Cardizem)-don’t take with high fat or high carb meal - Migraine prophylaxis- verapamil is most common - Raynauds- type 2 CCBs- nifedipine drug of choice 3. HYPERTENSION - ACEI, ARBS, DIURETICS 4. POST MI - Beta Blockers 5. Classes of Drugs - 1A,1B,1C: what do they have in common:: treat Ventricular arrhythmias & they are Sodium channel blockers - IA & III what do they have in common : they both block K channels - Which class prolongs action potential : Class III and 1A - APD- ACTION POTENTIAL DURATION