PHM 431 Exam 1 Questions with
Complete Solutions3
Describe drug tolerance - ANSWERS-Reduction in drug response after repeated drug
administration (downregulation of receptors or intracellular signaling molecules, for example)
What is a drug that could easily cross the blood brain barrier? - ANSWERS-Hydrophobic drug
(molecular weight = 240)
What set of drug properties is most likely to give a drug a high addiction liability? - ANSWERS-A
non-polar dopamine agonist with a molecular weight of 300
Loss of sensitivity to effects of drug due to changes in distribution or metabolism of drug is
called: - ANSWERS-Pharmacokinetic tolerance (mechanisms of metabolism/excretion
upregulated in chronic drug exposure)
Drug A alone has normal curve, Drug B is a flat line, and Drug A + B mimics the shape of Drug A
but is further right on the graph. What does this mean? - ANSWERS-Drug A is a full agonist;
Drug B is a competitive receptor antagonist
Plasma protein binding of a drug is an example of: - ANSWERS-Chemical antagonism (drug
interacts with another chemical to inactivate drug or make it inaccessible to site of action)
Many factors affect risk for drug addiction. What factor would NOT increase risk that an
individual will become addicted to a drug? - ANSWERS-High level of plasma protein binding
(Would increase are: high BBB permeability, release of DA in NAc, and rapid onset of drug
action)
Complete Solutions3
Describe drug tolerance - ANSWERS-Reduction in drug response after repeated drug
administration (downregulation of receptors or intracellular signaling molecules, for example)
What is a drug that could easily cross the blood brain barrier? - ANSWERS-Hydrophobic drug
(molecular weight = 240)
What set of drug properties is most likely to give a drug a high addiction liability? - ANSWERS-A
non-polar dopamine agonist with a molecular weight of 300
Loss of sensitivity to effects of drug due to changes in distribution or metabolism of drug is
called: - ANSWERS-Pharmacokinetic tolerance (mechanisms of metabolism/excretion
upregulated in chronic drug exposure)
Drug A alone has normal curve, Drug B is a flat line, and Drug A + B mimics the shape of Drug A
but is further right on the graph. What does this mean? - ANSWERS-Drug A is a full agonist;
Drug B is a competitive receptor antagonist
Plasma protein binding of a drug is an example of: - ANSWERS-Chemical antagonism (drug
interacts with another chemical to inactivate drug or make it inaccessible to site of action)
Many factors affect risk for drug addiction. What factor would NOT increase risk that an
individual will become addicted to a drug? - ANSWERS-High level of plasma protein binding
(Would increase are: high BBB permeability, release of DA in NAc, and rapid onset of drug
action)
