COMSAE Phase 1 Form 114 Exam And Practice Exam Newest 2026/2027 Test Bank | Comprehensive Osteopathic
Medical Self Assessment Examination Phase 1 Exam Prep With Complete 300 Real Exam Questions And Correct
Verified Answers | Already Graded A+ (Most Recent!)
300 QUESTIONS - COMSAE PHASE 1 FORM 114 BUNDLE - EXAM + PRACTICE EXAM - CORRECTED
- DISTINCT ANSWERS - MOST RECENT 2026/2027
DOMAIN 1: ANATOMY
Question 1
What is brachial plexus lesion Erb's palsy?
A. Only deliver classroom lectures with no medical knowledge
B. C5 C6 roots upper trunk lesion waiter's tip posture arm adducted internally rotated elbow extended forearm
pronated due to nursemaid birth injury
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: B
Rationale: Erb's palsy: C5-C6 upper trunk brachial plexus lesion, waiter's tip posture arm adducted internally rotated
elbow extended forearm pronated wrist flexed, loss deltoid biceps brachialis brachioradialis supraspinatus
infraspinatus, due to excessive lateral traction birth shoulder dystocia.
DOMAIN 1: ANATOMY
Question 2
What is carpal tunnel contents?
A. Only deliver classroom lectures with no medical knowledge
B. Only drive fire trucks and not teach medicine
C. Only inspect buildings and not manage medicine
D. 9 flexor tendons 4 FDS 4 FDP 1 FPL and median nerve, compression causes thenar atrophy sensory loss
thumb index middle half ring finger
Answer: D
Rationale: Carpal tunnel: 9 flexor tendons 4 flexor digitorum superficialis FDS 4 profundus FDP 1 flexor pollicis longus
FPL and median nerve under transverse carpal ligament flexor retinaculum, compression median nerve causes thenar
atrophy abductor pollicis brevis sensory loss palmar thumb index middle half ring, Phalen Tinel positive.
DOMAIN 1: ANATOMY
Question 3
What is femoral triangle contents?
A. Only inspect buildings and not manage medicine
B. From lateral medial NAVEL Nerve Artery Vein Empty space Lymphatics, femoral nerve artery vein within
triangle sartorius adductor longus inguinal ligament borders
C. Only drive fire trucks and not teach medicine
, D. Only deliver classroom lectures with no medical knowledge
Answer: B
Rationale: Femoral triangle: borders inguinal ligament superior sartorius lateral adductor longus medial, contents
lateral to medial NAVEL Nerve femoral nerve, Artery femoral artery, Vein femoral vein, Empty space femoral canal,
Lymphatics deep inguinal nodes Cloquet. Femoral hernia medial to vein through femoral canal.
DOMAIN 2: PHYSIOLOGY
Question 4
What is cardiac action potential phases?
A. Only inspect buildings and not manage medicine
B. Only deliver classroom lectures with no medical knowledge
C. Phase 0 fast Na+ influx, 1 transient K+ efflux, 2 Ca2+ influx plateau, 3 K+ efflux repolarization, 4 resting
membrane potential
D. Only drive fire trucks and not teach medicine
Answer: C
Rationale: Cardiac action potential ventricular: Phase 0 fast Na+ influx depolarization, Phase 1 transient K+ efflux Ito,
Phase 2 Ca2+ influx L-type plateau K+ efflux balance, Phase 3 K+ efflux rapid repolarization, Phase 4 resting -90 mV
K+ equilibrium. Pacemaker SA node Phase 4 funny current If slow diastolic depolarization Ca2+ T-type.
DOMAIN 2: PHYSIOLOGY
Question 5
What is Starling curve?
A. Only drive fire trucks and not teach medicine
B. Increased preload EDV increases stroke volume up to point via increased sarcomere stretch actin myosin
overlap
C. Only inspect buildings and not manage medicine
D. Only deliver classroom lectures with no medical knowledge
Answer: B
Rationale: Frank-Starling law: increased preload end-diastolic volume EDV increases stroke volume up to point due
increased sarcomere stretch optimal actin myosin overlap. Heart failure curve flattened decreased contractility.
Increased afterload decreases stroke volume. Increased contractility shifts curve up left.
DOMAIN 2: PHYSIOLOGY
Question 6
What is renal clearance equation?
A. Only drive fire trucks and not teach medicine
B. Clearance = U x V / P, U urine concentration V urine flow rate P plasma concentration, inulin GFR gold standard
, C. Only deliver classroom lectures with no medical knowledge
D. Only inspect buildings and not manage medicine
Answer: B
Rationale: Clearance: clearance = U x V / P, U urine concentration, V urine flow rate volume per time, P plasma
concentration. Inulin clearance = GFR gold standard freely filtered not secreted reabsorbed. Creatinine clearance
approximates GFR but slightly overestimates due secretion. PAH clearance = RPF renal plasma flow effectively
cleared.
DOMAIN 3: BIOCHEMISTRY
Question 7
What is rate limiting enzyme glycolysis?
A. Phosphofructokinase-1 PFK-1 inhibited ATP citrate H+ activated AMP fructose 2,6-bisphosphate
B. Only deliver classroom lectures with no medical knowledge
C. Only inspect buildings and not manage medicine
D. Only drive fire trucks and not teach medicine
Answer: A
Rationale: Glycolysis rate limiting: hexokinase glucokinase glucose to G6P, PFK-1 fructose 6P to fructose 1,6
bisphosphate rate limiting inhibited ATP citrate H+ activated AMP fructose 2,6-bisphosphate insulin, pyruvate kinase
PEP to pyruvate inhibited ATP alanine activated fructose 1,6 bisphosphate.
DOMAIN 3: BIOCHEMISTRY
Question 8
What is urea cycle?
A. Converts ammonia to urea in liver mitochondria cytosol 2 NH3 + CO2 + 3 ATP -> urea, rate limiting CPS1
carbamoyl phosphate synthetase I
B. Only deliver classroom lectures with no medical knowledge
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: A
Rationale: Urea cycle: converts toxic ammonia to urea in liver periportal cells mitochondria cytosol, 2 NH3 + CO2 + 3
ATP -> urea + 2 ADP + AMP + 4 Pi, rate limiting carbamoyl phosphate synthetase I CPS1 activated N-acetylglutamate,
ornithine cycle intermediates ornithine citrulline argininosuccinate arginine.
DOMAIN 3: BIOCHEMISTRY
Question 9
What is gluconeogenesis rate limiting?
, A. Pyruvate carboxylase pyruvate to oxaloacetate, PEPCK oxaloacetate to PEP, fructose 1,6 bisphosphatase,
glucose 6 phosphatase
B. Only deliver classroom lectures with no medical knowledge
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: A
Rationale: Gluconeogenesis rate limiting enzymes: pyruvate carboxylase pyruvate to oxaloacetate mitochondria biotin
ATP activated acetyl CoA, PEPCK phosphoenolpyruvate carboxykinase oxaloacetate to PEP GTP, fructose 1,6
bisphosphatase fructose 1,6 bisP to fructose 6P inhibited fructose 2,6 bisP AMP activated ATP, glucose 6
phosphatase glucose 6P to glucose ER only liver kidney.
DOMAIN 4: MICROBIOLOGY
Question 10
What is Gram positive cocci?
A. Staphylococcus aureus clusters catalase positive coagulase positive, Streptococcus pyogenes chains catalase
negative beta hemolytic
B. Only inspect buildings and not manage medicine
C. Only deliver classroom lectures with no medical knowledge
D. Only drive fire trucks and not teach medicine
Answer: A
Rationale: Gram positive cocci: Staphylococcus clusters catalase positive S. aureus coagulase positive protein A, S.
epidermidis coagulase negative novobiocin sensitive, S. saprophyticus novobiocin resistant UTI. Streptococcus chains
catalase negative S. pyogenes Group A beta hemolytic bacitracin sensitive, S. agalactiae Group B, S. pneumoniae
alpha hemolytic optochin sensitive bile soluble diplococcus.
DOMAIN 4: MICROBIOLOGY
Question 11
What is tuberculosis?
A. Mycobacterium tuberculosis acid fast bacilli caseating granulomas Ghon complex Ranke complex
B. Only deliver classroom lectures with no medical knowledge
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: A
Rationale: TB: Mycobacterium tuberculosis aerobic acid fast bacilli Ziehl-Neelsen stain, caseating granulomas
Langhans giant cells, transmission airborne droplet nuclei, primary Ghon focus lung plus hilar lymph node Ghon
complex Ranke complex calcified, secondary reactivation apical cavitary, PPD skin test interferon gamma release
assay IGRA, treatment RIPE rifampin isoniazid pyrazinamide ethambutol.
DOMAIN 4: MICROBIOLOGY
Medical Self Assessment Examination Phase 1 Exam Prep With Complete 300 Real Exam Questions And Correct
Verified Answers | Already Graded A+ (Most Recent!)
300 QUESTIONS - COMSAE PHASE 1 FORM 114 BUNDLE - EXAM + PRACTICE EXAM - CORRECTED
- DISTINCT ANSWERS - MOST RECENT 2026/2027
DOMAIN 1: ANATOMY
Question 1
What is brachial plexus lesion Erb's palsy?
A. Only deliver classroom lectures with no medical knowledge
B. C5 C6 roots upper trunk lesion waiter's tip posture arm adducted internally rotated elbow extended forearm
pronated due to nursemaid birth injury
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: B
Rationale: Erb's palsy: C5-C6 upper trunk brachial plexus lesion, waiter's tip posture arm adducted internally rotated
elbow extended forearm pronated wrist flexed, loss deltoid biceps brachialis brachioradialis supraspinatus
infraspinatus, due to excessive lateral traction birth shoulder dystocia.
DOMAIN 1: ANATOMY
Question 2
What is carpal tunnel contents?
A. Only deliver classroom lectures with no medical knowledge
B. Only drive fire trucks and not teach medicine
C. Only inspect buildings and not manage medicine
D. 9 flexor tendons 4 FDS 4 FDP 1 FPL and median nerve, compression causes thenar atrophy sensory loss
thumb index middle half ring finger
Answer: D
Rationale: Carpal tunnel: 9 flexor tendons 4 flexor digitorum superficialis FDS 4 profundus FDP 1 flexor pollicis longus
FPL and median nerve under transverse carpal ligament flexor retinaculum, compression median nerve causes thenar
atrophy abductor pollicis brevis sensory loss palmar thumb index middle half ring, Phalen Tinel positive.
DOMAIN 1: ANATOMY
Question 3
What is femoral triangle contents?
A. Only inspect buildings and not manage medicine
B. From lateral medial NAVEL Nerve Artery Vein Empty space Lymphatics, femoral nerve artery vein within
triangle sartorius adductor longus inguinal ligament borders
C. Only drive fire trucks and not teach medicine
, D. Only deliver classroom lectures with no medical knowledge
Answer: B
Rationale: Femoral triangle: borders inguinal ligament superior sartorius lateral adductor longus medial, contents
lateral to medial NAVEL Nerve femoral nerve, Artery femoral artery, Vein femoral vein, Empty space femoral canal,
Lymphatics deep inguinal nodes Cloquet. Femoral hernia medial to vein through femoral canal.
DOMAIN 2: PHYSIOLOGY
Question 4
What is cardiac action potential phases?
A. Only inspect buildings and not manage medicine
B. Only deliver classroom lectures with no medical knowledge
C. Phase 0 fast Na+ influx, 1 transient K+ efflux, 2 Ca2+ influx plateau, 3 K+ efflux repolarization, 4 resting
membrane potential
D. Only drive fire trucks and not teach medicine
Answer: C
Rationale: Cardiac action potential ventricular: Phase 0 fast Na+ influx depolarization, Phase 1 transient K+ efflux Ito,
Phase 2 Ca2+ influx L-type plateau K+ efflux balance, Phase 3 K+ efflux rapid repolarization, Phase 4 resting -90 mV
K+ equilibrium. Pacemaker SA node Phase 4 funny current If slow diastolic depolarization Ca2+ T-type.
DOMAIN 2: PHYSIOLOGY
Question 5
What is Starling curve?
A. Only drive fire trucks and not teach medicine
B. Increased preload EDV increases stroke volume up to point via increased sarcomere stretch actin myosin
overlap
C. Only inspect buildings and not manage medicine
D. Only deliver classroom lectures with no medical knowledge
Answer: B
Rationale: Frank-Starling law: increased preload end-diastolic volume EDV increases stroke volume up to point due
increased sarcomere stretch optimal actin myosin overlap. Heart failure curve flattened decreased contractility.
Increased afterload decreases stroke volume. Increased contractility shifts curve up left.
DOMAIN 2: PHYSIOLOGY
Question 6
What is renal clearance equation?
A. Only drive fire trucks and not teach medicine
B. Clearance = U x V / P, U urine concentration V urine flow rate P plasma concentration, inulin GFR gold standard
, C. Only deliver classroom lectures with no medical knowledge
D. Only inspect buildings and not manage medicine
Answer: B
Rationale: Clearance: clearance = U x V / P, U urine concentration, V urine flow rate volume per time, P plasma
concentration. Inulin clearance = GFR gold standard freely filtered not secreted reabsorbed. Creatinine clearance
approximates GFR but slightly overestimates due secretion. PAH clearance = RPF renal plasma flow effectively
cleared.
DOMAIN 3: BIOCHEMISTRY
Question 7
What is rate limiting enzyme glycolysis?
A. Phosphofructokinase-1 PFK-1 inhibited ATP citrate H+ activated AMP fructose 2,6-bisphosphate
B. Only deliver classroom lectures with no medical knowledge
C. Only inspect buildings and not manage medicine
D. Only drive fire trucks and not teach medicine
Answer: A
Rationale: Glycolysis rate limiting: hexokinase glucokinase glucose to G6P, PFK-1 fructose 6P to fructose 1,6
bisphosphate rate limiting inhibited ATP citrate H+ activated AMP fructose 2,6-bisphosphate insulin, pyruvate kinase
PEP to pyruvate inhibited ATP alanine activated fructose 1,6 bisphosphate.
DOMAIN 3: BIOCHEMISTRY
Question 8
What is urea cycle?
A. Converts ammonia to urea in liver mitochondria cytosol 2 NH3 + CO2 + 3 ATP -> urea, rate limiting CPS1
carbamoyl phosphate synthetase I
B. Only deliver classroom lectures with no medical knowledge
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: A
Rationale: Urea cycle: converts toxic ammonia to urea in liver periportal cells mitochondria cytosol, 2 NH3 + CO2 + 3
ATP -> urea + 2 ADP + AMP + 4 Pi, rate limiting carbamoyl phosphate synthetase I CPS1 activated N-acetylglutamate,
ornithine cycle intermediates ornithine citrulline argininosuccinate arginine.
DOMAIN 3: BIOCHEMISTRY
Question 9
What is gluconeogenesis rate limiting?
, A. Pyruvate carboxylase pyruvate to oxaloacetate, PEPCK oxaloacetate to PEP, fructose 1,6 bisphosphatase,
glucose 6 phosphatase
B. Only deliver classroom lectures with no medical knowledge
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: A
Rationale: Gluconeogenesis rate limiting enzymes: pyruvate carboxylase pyruvate to oxaloacetate mitochondria biotin
ATP activated acetyl CoA, PEPCK phosphoenolpyruvate carboxykinase oxaloacetate to PEP GTP, fructose 1,6
bisphosphatase fructose 1,6 bisP to fructose 6P inhibited fructose 2,6 bisP AMP activated ATP, glucose 6
phosphatase glucose 6P to glucose ER only liver kidney.
DOMAIN 4: MICROBIOLOGY
Question 10
What is Gram positive cocci?
A. Staphylococcus aureus clusters catalase positive coagulase positive, Streptococcus pyogenes chains catalase
negative beta hemolytic
B. Only inspect buildings and not manage medicine
C. Only deliver classroom lectures with no medical knowledge
D. Only drive fire trucks and not teach medicine
Answer: A
Rationale: Gram positive cocci: Staphylococcus clusters catalase positive S. aureus coagulase positive protein A, S.
epidermidis coagulase negative novobiocin sensitive, S. saprophyticus novobiocin resistant UTI. Streptococcus chains
catalase negative S. pyogenes Group A beta hemolytic bacitracin sensitive, S. agalactiae Group B, S. pneumoniae
alpha hemolytic optochin sensitive bile soluble diplococcus.
DOMAIN 4: MICROBIOLOGY
Question 11
What is tuberculosis?
A. Mycobacterium tuberculosis acid fast bacilli caseating granulomas Ghon complex Ranke complex
B. Only deliver classroom lectures with no medical knowledge
C. Only drive fire trucks and not teach medicine
D. Only inspect buildings and not manage medicine
Answer: A
Rationale: TB: Mycobacterium tuberculosis aerobic acid fast bacilli Ziehl-Neelsen stain, caseating granulomas
Langhans giant cells, transmission airborne droplet nuclei, primary Ghon focus lung plus hilar lymph node Ghon
complex Ranke complex calcified, secondary reactivation apical cavitary, PPD skin test interferon gamma release
assay IGRA, treatment RIPE rifampin isoniazid pyrazinamide ethambutol.
DOMAIN 4: MICROBIOLOGY
