Molecular Diagnostics Chapter 14
Question 1.
MHC
ANSWER
Major Histocompatability complex, a set of proteins found on the plasma membranes of cells that help display antigen to T cells. MHC I is found on all cells
and displays bits of proteins from within the cell; this allows T cells to monitor cell contents and if abnormal peptides are displayed on the surface, the cell is
destroyed by killer T cells. MHC II is found only on macrophages and B cells. This class of MHC allows these cells (known as antigen presenting cells) to
display bitts of "eaten" (phagocytosed or internalized ) proteins on their surface, allowing the activation of helper Ts --> thus further activating immune
response.
Question 2.
In humans what is the MHC called? Which chromosome is it located on?
ANSWER
HLA, 6
Question 3.
MHC class I HLA type
ANSWER
HLA-A, HLA-B, HLA-C, one alpha chain and beta-2 micro globulin
Question 4.
MHC class II HLA type
ANSWER
HLA-D, two chains one alpha one beta
Question 5.
ambiguity
ANSWER
recognition of two or more antigens by the same antibody so the allele cannot be called
Question 6.
resolution
ANSWER
level of detail the allele is observed
Question 7.
HLA typing
ANSWER
the process by which the human leucocyte antigens (HLA) present on a person's cells are identified, typically for the purpose of matching a donor tissue or
organ to the most compatible recipient -through protein or dna
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Question 1.
MHC
ANSWER
Major Histocompatability complex, a set of proteins found on the plasma membranes of cells that help display antigen to T cells. MHC I is found on all cells
and displays bits of proteins from within the cell; this allows T cells to monitor cell contents and if abnormal peptides are displayed on the surface, the cell is
destroyed by killer T cells. MHC II is found only on macrophages and B cells. This class of MHC allows these cells (known as antigen presenting cells) to
display bitts of "eaten" (phagocytosed or internalized ) proteins on their surface, allowing the activation of helper Ts --> thus further activating immune
response.
Question 2.
In humans what is the MHC called? Which chromosome is it located on?
ANSWER
HLA, 6
Question 3.
MHC class I HLA type
ANSWER
HLA-A, HLA-B, HLA-C, one alpha chain and beta-2 micro globulin
Question 4.
MHC class II HLA type
ANSWER
HLA-D, two chains one alpha one beta
Question 5.
ambiguity
ANSWER
recognition of two or more antigens by the same antibody so the allele cannot be called
Question 6.
resolution
ANSWER
level of detail the allele is observed
Question 7.
HLA typing
ANSWER
the process by which the human leucocyte antigens (HLA) present on a person's cells are identified, typically for the purpose of matching a donor tissue or
organ to the most compatible recipient -through protein or dna
1/4
