NR566 Midterm Practice Examination /
NR566 MIDTERM - Study guides, Class
notes & Summaries
,Instructions: Select the single best answer for each question.
Each question is followed by the Correct Answer and a detailed
explanation.
Question 1
A 72-year-old woman with a history of heart failure is prescribed furosemide.
Which pharmacokinetic change associated with aging most directly increases her
risk of drug accumulation and toxicity?
A. Increased gastric pH
B. Decreased glomerular filtration rate
C. Increased hepatic blood flow
D. Enhanced first-pass metabolism
Correct Answer: B
Explanation: Aging reduces renal clearance, prolonging elimination of renally
excreted drugs like furosemide and increasing toxicity risk; monitor renal function
closely in older adults.
Question 2
A 45-year-old man is a known CYP2D6 ultrarapid metabolizer. Which clinical
consequence is most likely if he is prescribed codeine for pain control?
A. Lack of analgesic effect
B. Excessive sedation from parent drug accumulation
C. Increased conversion to morphine and risk of toxicity
D. Complete failure of hepatic activation
Correct Answer: C
NR566 MIDTERM - Study guides, Class
notes & Summaries
,Instructions: Select the single best answer for each question.
Each question is followed by the Correct Answer and a detailed
explanation.
Question 1
A 72-year-old woman with a history of heart failure is prescribed furosemide.
Which pharmacokinetic change associated with aging most directly increases her
risk of drug accumulation and toxicity?
A. Increased gastric pH
B. Decreased glomerular filtration rate
C. Increased hepatic blood flow
D. Enhanced first-pass metabolism
Correct Answer: B
Explanation: Aging reduces renal clearance, prolonging elimination of renally
excreted drugs like furosemide and increasing toxicity risk; monitor renal function
closely in older adults.
Question 2
A 45-year-old man is a known CYP2D6 ultrarapid metabolizer. Which clinical
consequence is most likely if he is prescribed codeine for pain control?
A. Lack of analgesic effect
B. Excessive sedation from parent drug accumulation
C. Increased conversion to morphine and risk of toxicity
D. Complete failure of hepatic activation
Correct Answer: C
