untiammation.
restrict
calor
rubor
remove
damage.
cardina Siqn
heat av
eruthema
tu mor bedema
ddior pain
Acute intlammatio n
CLINICAL
inflammatory disease
inflammation/9ad160s
causutive
agent
initial. transientresponse
IMMUNOLOG
alow cenacess,
immune repair - 611:81
beneficial effect
mation
dilnte
toxin.
andw
harm effect
nutnent.
entry.
üntibody 02 for
delivery-fibrin
resease
of lusosomaienzyme breakdown
peptidogiycan of baitena
Typel nypersensitivity
swellina
eme
pigiottis due
ningítis
toHaemophilus
aiute brain to
it|nenzmeobstruct
impair biondHou
airway
innatecells recruitedkeu snio300w od N
macrophage
DC
hentrophil
mast ceu
P/DAMPs (pathogen/ damage
associated
moiecular
pattern)activation
via
banding toFoRe to PRR
(patternrecoqnition
receptor) IgE
u( NMU or
-.
LPS /TLR-4 FímM/ CD48 Neuromedin ) / NMU-RIandR2
mtlammatory mediator
Ispid mediator
of reieasearange
PGD2.LTB 4. LTCH NOWDING
cutokine
TNF d IL-3.6.10
Preformed medrator 92A090NX0
Serine
protease.protedarycan A.Wistamine
carboxypeptidase
step
I7re/raborsv
vasolidation exudation
Capillary widening capibaru permeabilrtua
biood injury-2: increased
tissue
flovo fluid release
.TAO
attraction of wbl sustemic response
miaration TD
of WBU fever. proliferatinofwBc
mjurn
margination. emigration
inflammation pedema
normal: Aluid movement out at artenpie at venous
incrensedvastuiar permeability
generated source
vasoactivemedratorfrompiasma cemmiar Are
at tissue mjury Site
dedema
pitting SSA
x lymphedema:
non-intlammatori
, chemical
permeability
stored
Preformed.
mediator
withen
ceml
derived
demlas
mediator
cytoplasmic
of
granule
icreased
vascul
serotonin
truptase
histamine
release
Stored.from
etfect
pharmacDiDaic
mast
cell.
basophil
.eosinophil Pa7
plateleta
Arteriole transient dilation of
increased vascuiar
bin d To of l 4major
eariy venule
permeabilityin
ofhistamine
tupes receptor NYa
6I0Sb30
NO
HI 8mooth
muscle.
endotheiral
cell
activationphosphulipaseof ->
A.C
NOiEmmNEA3230
H5 gastric parietal ceu 1p1370/98
H3 CNS
HA : mast ceu. Dc ceu.eosinophilI+vren92hesNN
T
ONTSWE
arachidonitacid derivative 8150/0759
Prostagladin
thromboxane
pyostanoid.
derive
eicosanaid…:
metaboiism
from
to
refery as
longcharn
ofarachidonic
leukotriene acrd:
unsaturated
fatty acndomy
arachidonic aud 11N9A
manycentupe of
stored in membrane
releasecan
be mnitiatedby MAgS MolRY
8.AS
hista mine 3
nentrophil with damagedtissue
monolyte 010159N
effect : localized hIça
2 pathway
8/070/13S
cycio-oxygenase pathway
+hromboxaneA a
prodnue prostaqiadin thromboxane +
J agareaate piatelet
vasoconstriction
prostacyolin (PGI2)
-
00T9N08SV
inhibit piaferetagqregation
stable prostagiadin vasodilation
PGD2 0VGl
PGEz: pain. fever
PG F2
OUACEOTAN
Irpoxygenase pathway 5
produceleukotriene
occur in neutrophil AINSOS
01
LT C l Smoothmusclecontraction
LT D$
LT E4
00G
neutrophil adhesion
LTB4- Stimuiate ceu
to endotheiral
chemotactic
, phospholipidderivative
factor
piareietsactivating
Synthesized
(PAF.)WNaNTOANS
9/8cM me
by
mastcell SIRN
endothelar
celll 1531h DI BANOGNYG3
1ONGDOEDY 9VINOA
b aso
•
phil
nentrophil 1038A000
AMERO .0 AVI13.
(VOPNLOS: monocute F NIATNIOO
MSMINSNS
6601883
platelet N86.
function Bsiy.92 *0 SBNSTOS
IR1TI3NNS4
increasepiatelet agqregation
D/v:8 MOMViJA
Phagocytosisyownt
triggers
chemotactic
arachidonicaud sms:
metabolismmod
STANDNSR
10.0roohn
cytokine 03
lymphocyte.monocute
smallactivated
seukocute
protein prodncts of
ontarget cen
Interactwith specific receptor
torm a concentrationgradient
controuer
of directedcen ) : chemokine
migration( chemotaxis
tumonr
necrosisfactor aipha ( TNFd
)SYAINS3NHNOe:
to: Iprincipie mediator
response
bacteriagram
infections microbe ther
=
of aunte infiammatory
activated
biologic
macrophage( mononnciear
function
phagocyte)
AMIADHJ 67030 R:
source:
37AVTIN
canse
vascular to express
endothelial adhesion
maiecule
(selectin)
a11ownentrophìl. monocute.
Iymphocuteto adnere
endothelium
miaratronto tissne
prior 37OVA
Stimuiateendothelialsecretechemokine
cells To
chemotaxts. recruitment induce mynohinZolg
StimuiateiIL-I macrophageto secrete
indnceapoptosis TNUI M7STX1UA2STC
severeinfection Systemic shocklarge amount of TNFCauses
inducefever acts onhypothaiamns to
prostagiadin by increased sythesis of
acts onhepatocyte 1ini:
increaseSynthesis of Serum protein: Serum amyloid A protein
frbrinogen m
interlenkin-I(IL-I) 8N09091
activatedmononuciear
phagocute. inducedby LPS.TNFSonrce:
Function
low concentration : mediator of local Inflammation
concentration high 9/dicncq8ST 21
circuiation enter
endocrine effect induce fever.acute phaseprotein synthesis.
NINIGANW19C IN NV
wasting 'metabolic
43501gTnitrate
chemokine(IL-g XNqR•
chemotrautive cutokine residueciassifiedby N-terminal
cysterne
Stimuiate lenkocyte movement.migration
chemokine on
receptor expressed leukoyte with1Tm d-helicaldomain
exhibitCXCR22
Function
|L-8. overlappingspecificity
NAP-2.ENA18.Gro-a.by :
recruit cens to cc.lxc major
hostInfectionsite of defense :
mindY: C. CX3C
nentrophil for IL- 8
chemotactic
edsinophil eotaxinfor
tissue
penpheral requiatetratficoflymphouyte
lymphoid throngh
, Mitric oxide
by endothelium
Sunthesized macrophage bynitricoxrdesunthase
(NoS)
vasodilator NONSTICANZA
diffuse into smoothmuscle 4da t
Short hai life
Activevasodilator in : Nol.nitrte40200
druq compound oxide rodical
GINGOYNAS
mediatorderivedplasma
enzymaticcascade
geries each
contain
which
oceurs
cascade
produceinfiammatory
ASaof inaltiveprecusor
andas
a 4
mediator
A013
series
ofsequentiai when
proteases
N0T7I
triqgered
19/91010 $4N 973NIL
compiementactivation l. Qiternative PathwayzebroapsaNg
.
qenerate breakdown
Compiement product:3:10RISA0IIE
0740209AS
C3a
3
92NO00LONY
C5a 3chemotactic
Agent 1J002 Nhore Ni9ong
0A:JZNT
anaphyiatoxin
träiS
C3
C 4.
: Smooth
asna musdle
contraction
32bind
vascuiar
permeabilitygi?:
on
toreteptor lenkoyte
release
further ofhistamin
8t30.G0 from mastcem.
C 5 a 09amoqaSTNJ0100/RIEn basophil
0T1ST 0I MATA
odgrot.: enoi+asinl1907
2. coaquiation SyStemNeN OANgO3NO 970VIZJA
Activated factor XIl factor.xula)activared
Hageman by
contalt
(nttasoa with.charged
MUIOnONIGINOIONDs
basai
surface
CMINI
lamina. ofbacterial
enzymne
activate : :0 1101A1M
xua 91
plasminogen piasmin holso3 AlSi
activate:05 mita
prekallikrein- kallikrein Jiberate C5a
TSVS.
100 EMT
Kininsystem3. DEAIDDRZ
bradykinin
Amediate
Mi9tOdincreasevascuiar
pain
permeabilityiasataNal
9M7
prolonged response
infiammatory
4. Fibrinotyticusystemnaolle
lvsi's res
min
-
pias foriSfibrin
ponsibie
089 9 9
piasmin .AESNINNO
fibrin Taaer
.19V3-
NTS2OYS
fsbrinbreakdown
FDPX
product -> vascuiar permeability
03a Sr Cleave C3 to
RNINIDY S1
1x0r..D 90N00AN 3.
MTELnSTo E
CAU.8:420X 8 ADI9Q0LL9NO
9118 003SNT9
: hndamN/InanqN9GdeNGaE
restrict
calor
rubor
remove
damage.
cardina Siqn
heat av
eruthema
tu mor bedema
ddior pain
Acute intlammatio n
CLINICAL
inflammatory disease
inflammation/9ad160s
causutive
agent
initial. transientresponse
IMMUNOLOG
alow cenacess,
immune repair - 611:81
beneficial effect
mation
dilnte
toxin.
andw
harm effect
nutnent.
entry.
üntibody 02 for
delivery-fibrin
resease
of lusosomaienzyme breakdown
peptidogiycan of baitena
Typel nypersensitivity
swellina
eme
pigiottis due
ningítis
toHaemophilus
aiute brain to
it|nenzmeobstruct
impair biondHou
airway
innatecells recruitedkeu snio300w od N
macrophage
DC
hentrophil
mast ceu
P/DAMPs (pathogen/ damage
associated
moiecular
pattern)activation
via
banding toFoRe to PRR
(patternrecoqnition
receptor) IgE
u( NMU or
-.
LPS /TLR-4 FímM/ CD48 Neuromedin ) / NMU-RIandR2
mtlammatory mediator
Ispid mediator
of reieasearange
PGD2.LTB 4. LTCH NOWDING
cutokine
TNF d IL-3.6.10
Preformed medrator 92A090NX0
Serine
protease.protedarycan A.Wistamine
carboxypeptidase
step
I7re/raborsv
vasolidation exudation
Capillary widening capibaru permeabilrtua
biood injury-2: increased
tissue
flovo fluid release
.TAO
attraction of wbl sustemic response
miaration TD
of WBU fever. proliferatinofwBc
mjurn
margination. emigration
inflammation pedema
normal: Aluid movement out at artenpie at venous
incrensedvastuiar permeability
generated source
vasoactivemedratorfrompiasma cemmiar Are
at tissue mjury Site
dedema
pitting SSA
x lymphedema:
non-intlammatori
, chemical
permeability
stored
Preformed.
mediator
withen
ceml
derived
demlas
mediator
cytoplasmic
of
granule
icreased
vascul
serotonin
truptase
histamine
release
Stored.from
etfect
pharmacDiDaic
mast
cell.
basophil
.eosinophil Pa7
plateleta
Arteriole transient dilation of
increased vascuiar
bin d To of l 4major
eariy venule
permeabilityin
ofhistamine
tupes receptor NYa
6I0Sb30
NO
HI 8mooth
muscle.
endotheiral
cell
activationphosphulipaseof ->
A.C
NOiEmmNEA3230
H5 gastric parietal ceu 1p1370/98
H3 CNS
HA : mast ceu. Dc ceu.eosinophilI+vren92hesNN
T
ONTSWE
arachidonitacid derivative 8150/0759
Prostagladin
thromboxane
pyostanoid.
derive
eicosanaid…:
metaboiism
from
to
refery as
longcharn
ofarachidonic
leukotriene acrd:
unsaturated
fatty acndomy
arachidonic aud 11N9A
manycentupe of
stored in membrane
releasecan
be mnitiatedby MAgS MolRY
8.AS
hista mine 3
nentrophil with damagedtissue
monolyte 010159N
effect : localized hIça
2 pathway
8/070/13S
cycio-oxygenase pathway
+hromboxaneA a
prodnue prostaqiadin thromboxane +
J agareaate piatelet
vasoconstriction
prostacyolin (PGI2)
-
00T9N08SV
inhibit piaferetagqregation
stable prostagiadin vasodilation
PGD2 0VGl
PGEz: pain. fever
PG F2
OUACEOTAN
Irpoxygenase pathway 5
produceleukotriene
occur in neutrophil AINSOS
01
LT C l Smoothmusclecontraction
LT D$
LT E4
00G
neutrophil adhesion
LTB4- Stimuiate ceu
to endotheiral
chemotactic
, phospholipidderivative
factor
piareietsactivating
Synthesized
(PAF.)WNaNTOANS
9/8cM me
by
mastcell SIRN
endothelar
celll 1531h DI BANOGNYG3
1ONGDOEDY 9VINOA
b aso
•
phil
nentrophil 1038A000
AMERO .0 AVI13.
(VOPNLOS: monocute F NIATNIOO
MSMINSNS
6601883
platelet N86.
function Bsiy.92 *0 SBNSTOS
IR1TI3NNS4
increasepiatelet agqregation
D/v:8 MOMViJA
Phagocytosisyownt
triggers
chemotactic
arachidonicaud sms:
metabolismmod
STANDNSR
10.0roohn
cytokine 03
lymphocyte.monocute
smallactivated
seukocute
protein prodncts of
ontarget cen
Interactwith specific receptor
torm a concentrationgradient
controuer
of directedcen ) : chemokine
migration( chemotaxis
tumonr
necrosisfactor aipha ( TNFd
)SYAINS3NHNOe:
to: Iprincipie mediator
response
bacteriagram
infections microbe ther
=
of aunte infiammatory
activated
biologic
macrophage( mononnciear
function
phagocyte)
AMIADHJ 67030 R:
source:
37AVTIN
canse
vascular to express
endothelial adhesion
maiecule
(selectin)
a11ownentrophìl. monocute.
Iymphocuteto adnere
endothelium
miaratronto tissne
prior 37OVA
Stimuiateendothelialsecretechemokine
cells To
chemotaxts. recruitment induce mynohinZolg
StimuiateiIL-I macrophageto secrete
indnceapoptosis TNUI M7STX1UA2STC
severeinfection Systemic shocklarge amount of TNFCauses
inducefever acts onhypothaiamns to
prostagiadin by increased sythesis of
acts onhepatocyte 1ini:
increaseSynthesis of Serum protein: Serum amyloid A protein
frbrinogen m
interlenkin-I(IL-I) 8N09091
activatedmononuciear
phagocute. inducedby LPS.TNFSonrce:
Function
low concentration : mediator of local Inflammation
concentration high 9/dicncq8ST 21
circuiation enter
endocrine effect induce fever.acute phaseprotein synthesis.
NINIGANW19C IN NV
wasting 'metabolic
43501gTnitrate
chemokine(IL-g XNqR•
chemotrautive cutokine residueciassifiedby N-terminal
cysterne
Stimuiate lenkocyte movement.migration
chemokine on
receptor expressed leukoyte with1Tm d-helicaldomain
exhibitCXCR22
Function
|L-8. overlappingspecificity
NAP-2.ENA18.Gro-a.by :
recruit cens to cc.lxc major
hostInfectionsite of defense :
mindY: C. CX3C
nentrophil for IL- 8
chemotactic
edsinophil eotaxinfor
tissue
penpheral requiatetratficoflymphouyte
lymphoid throngh
, Mitric oxide
by endothelium
Sunthesized macrophage bynitricoxrdesunthase
(NoS)
vasodilator NONSTICANZA
diffuse into smoothmuscle 4da t
Short hai life
Activevasodilator in : Nol.nitrte40200
druq compound oxide rodical
GINGOYNAS
mediatorderivedplasma
enzymaticcascade
geries each
contain
which
oceurs
cascade
produceinfiammatory
ASaof inaltiveprecusor
andas
a 4
mediator
A013
series
ofsequentiai when
proteases
N0T7I
triqgered
19/91010 $4N 973NIL
compiementactivation l. Qiternative PathwayzebroapsaNg
.
qenerate breakdown
Compiement product:3:10RISA0IIE
0740209AS
C3a
3
92NO00LONY
C5a 3chemotactic
Agent 1J002 Nhore Ni9ong
0A:JZNT
anaphyiatoxin
träiS
C3
C 4.
: Smooth
asna musdle
contraction
32bind
vascuiar
permeabilitygi?:
on
toreteptor lenkoyte
release
further ofhistamin
8t30.G0 from mastcem.
C 5 a 09amoqaSTNJ0100/RIEn basophil
0T1ST 0I MATA
odgrot.: enoi+asinl1907
2. coaquiation SyStemNeN OANgO3NO 970VIZJA
Activated factor XIl factor.xula)activared
Hageman by
contalt
(nttasoa with.charged
MUIOnONIGINOIONDs
basai
surface
CMINI
lamina. ofbacterial
enzymne
activate : :0 1101A1M
xua 91
plasminogen piasmin holso3 AlSi
activate:05 mita
prekallikrein- kallikrein Jiberate C5a
TSVS.
100 EMT
Kininsystem3. DEAIDDRZ
bradykinin
Amediate
Mi9tOdincreasevascuiar
pain
permeabilityiasataNal
9M7
prolonged response
infiammatory
4. Fibrinotyticusystemnaolle
lvsi's res
min
-
pias foriSfibrin
ponsibie
089 9 9
piasmin .AESNINNO
fibrin Taaer
.19V3-
NTS2OYS
fsbrinbreakdown
FDPX
product -> vascuiar permeability
03a Sr Cleave C3 to
RNINIDY S1
1x0r..D 90N00AN 3.
MTELnSTo E
CAU.8:420X 8 ADI9Q0LL9NO
9118 003SNT9
: hndamN/InanqN9GdeNGaE
