1
Usmle
Usmle Step 1 First Aid Exam 2026
Questions with Correct Verified
Solutions 100% Guaranteed Pass
Hypersensitivity vasculitis associated with hemorrhagic urticaria and
upper respiratory tract infections - diagnosis? - ANS ✓henoch-schonlein
purpura
Most common tumor of infancy - ANS ✓hemangioma
Charcot's triad of multiple sclerosis - ANS ✓nystagmus, intention
tremor, scanning speech (where the same emphasis is put on each syllable
like scanning a poem)
Most common causes of dic - ANS ✓gram-negative sepsis, obstetric
complications, cancer, burn trauma
Most common cause of myocarditis - ANS ✓coxsackie b
Kussmaul hyperpnea - diagnosis? - ANS ✓diabetic ketoacidosis
Lisch nodules - diagnosis? - ANS ✓neurofibromatosis (von
recklinghausen's disease)
Polyneuropathy, cardiac pathology, and edema - diagnosis?
Usmle Step 1 First Aid
, 2
Usmle
- what causes it? - ANS ✓wet beriberi (vitamin b1 deficiency)
Most common malignancy associated with noninfectious fever - ANS
✓Hodgkin’s disease
Port-wine stain - diagnosis? - ANS ✓hemangioma
What is trousseau's sign of malignancy?
- possible diagnoses? - ANS ✓migratory thrombophlebitis
- visceral cancer or pancreatic adenocarcinoma
Homer wright rosettes - diagnosis? - ANS ✓neuroblastoma
What is trousseau's sign of latent tetany?
- diagnosis? - ANS ✓carpal spasm
- hypocalcemia
What is Virchow’s triad?
- predilection for what? - ANS ✓blood stasis, endothelial damage,
hypercoagulation
- pulmonary embolism
What is von recklinghausen's disease of bone? - ANS ✓osteitis fibrosa
cystica ("brown tumor")
Usmle Step 1 First Aid
, 3
Usmle
Adrenal hemorrhage associated with meningococcemia - diagnosis? -
ANS ✓waterhouse-friderichsen syndrome
Most common cause of hemochromatosis
- causes risk of? - ANS ✓multiple blood transfusions
- can cause chf and increased risk of hepatocellular carcinoma
Mechanism of action of macrolides and clindamycin? - ANS ✓bind 50s
subunit and block translocation
Most common cause of congenital adrenal hyperplasia - ANS ✓21-
hydroxylase deficiency
Most common tumor of the adrenal medulla in kids
- benign or malignant? - ANS ✓neuroblastoma - malignant
Most common cause of siadh - ANS ✓small cell carcinoma of the lung
Most common cause of cushing's syndrome
- 2nd most common? - ANS ✓corticosteroid therapy
- excess acth secretion by pituitary is 2nd
Most common cause of hypopituitarism - ANS ✓adenoma
Suboccipital lymphadenopathy - diagnosis? - ANS ✓rubella
Usmle Step 1 First Aid
, 4
Usmle
Most common vasculitis
- poses risk for?
- what causes this? - ANS ✓temporal arteritis
- risk of ipsilateral blindness - due to thrombosis of opthalmic artery
Most common cause of hepatocellular carcinoma - ANS ✓cirrhotic liver,
often due to hepatitis b and c
Most common cause of viral encephalitis - ANS ✓hsv
What is the defect in chediak-higashi syndrome?
- symptoms? - ANS ✓defect in microtubule polymerization, causing
decreased phagocytosis
- symptoms: recurrent pyogenic infections, partial albinism,
peripheral neuropathy
Most common cause of addison's
- 2nd most common? - ANS ✓autoimmune
- infection is 2nd
"smudge cell" - diagnosis? - ANS ✓cll
Most common cause of constrictive pericarditis - ANS ✓tuberculosis
Soap bubble on x-ray - diagnosis? - ANS ✓giant cell tumor of bone
Usmle Step 1 First Aid
Usmle
Usmle Step 1 First Aid Exam 2026
Questions with Correct Verified
Solutions 100% Guaranteed Pass
Hypersensitivity vasculitis associated with hemorrhagic urticaria and
upper respiratory tract infections - diagnosis? - ANS ✓henoch-schonlein
purpura
Most common tumor of infancy - ANS ✓hemangioma
Charcot's triad of multiple sclerosis - ANS ✓nystagmus, intention
tremor, scanning speech (where the same emphasis is put on each syllable
like scanning a poem)
Most common causes of dic - ANS ✓gram-negative sepsis, obstetric
complications, cancer, burn trauma
Most common cause of myocarditis - ANS ✓coxsackie b
Kussmaul hyperpnea - diagnosis? - ANS ✓diabetic ketoacidosis
Lisch nodules - diagnosis? - ANS ✓neurofibromatosis (von
recklinghausen's disease)
Polyneuropathy, cardiac pathology, and edema - diagnosis?
Usmle Step 1 First Aid
, 2
Usmle
- what causes it? - ANS ✓wet beriberi (vitamin b1 deficiency)
Most common malignancy associated with noninfectious fever - ANS
✓Hodgkin’s disease
Port-wine stain - diagnosis? - ANS ✓hemangioma
What is trousseau's sign of malignancy?
- possible diagnoses? - ANS ✓migratory thrombophlebitis
- visceral cancer or pancreatic adenocarcinoma
Homer wright rosettes - diagnosis? - ANS ✓neuroblastoma
What is trousseau's sign of latent tetany?
- diagnosis? - ANS ✓carpal spasm
- hypocalcemia
What is Virchow’s triad?
- predilection for what? - ANS ✓blood stasis, endothelial damage,
hypercoagulation
- pulmonary embolism
What is von recklinghausen's disease of bone? - ANS ✓osteitis fibrosa
cystica ("brown tumor")
Usmle Step 1 First Aid
, 3
Usmle
Adrenal hemorrhage associated with meningococcemia - diagnosis? -
ANS ✓waterhouse-friderichsen syndrome
Most common cause of hemochromatosis
- causes risk of? - ANS ✓multiple blood transfusions
- can cause chf and increased risk of hepatocellular carcinoma
Mechanism of action of macrolides and clindamycin? - ANS ✓bind 50s
subunit and block translocation
Most common cause of congenital adrenal hyperplasia - ANS ✓21-
hydroxylase deficiency
Most common tumor of the adrenal medulla in kids
- benign or malignant? - ANS ✓neuroblastoma - malignant
Most common cause of siadh - ANS ✓small cell carcinoma of the lung
Most common cause of cushing's syndrome
- 2nd most common? - ANS ✓corticosteroid therapy
- excess acth secretion by pituitary is 2nd
Most common cause of hypopituitarism - ANS ✓adenoma
Suboccipital lymphadenopathy - diagnosis? - ANS ✓rubella
Usmle Step 1 First Aid
, 4
Usmle
Most common vasculitis
- poses risk for?
- what causes this? - ANS ✓temporal arteritis
- risk of ipsilateral blindness - due to thrombosis of opthalmic artery
Most common cause of hepatocellular carcinoma - ANS ✓cirrhotic liver,
often due to hepatitis b and c
Most common cause of viral encephalitis - ANS ✓hsv
What is the defect in chediak-higashi syndrome?
- symptoms? - ANS ✓defect in microtubule polymerization, causing
decreased phagocytosis
- symptoms: recurrent pyogenic infections, partial albinism,
peripheral neuropathy
Most common cause of addison's
- 2nd most common? - ANS ✓autoimmune
- infection is 2nd
"smudge cell" - diagnosis? - ANS ✓cll
Most common cause of constrictive pericarditis - ANS ✓tuberculosis
Soap bubble on x-ray - diagnosis? - ANS ✓giant cell tumor of bone
Usmle Step 1 First Aid
