CMN 548 MODULE 3 COMPLETE STUDY GUIDE
WITH ANSWERS
◉ Agonist (full agonist).
Answer: A drug that binds to a specific receptor producing an effect
identical to that usually produced by the neurotransmitter affecting
that receptor
◉ Pharmacodynamics.
Answer: The time course and intensity of a drug's effect/what the
drug does to the body
◉ Pharmacokinetics.
Answer: What the body does to a drug
◉ Tolerance.
Answer: Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased
sensitivity to adverse effects of a drug
◉ Stevens-Johnson Syndrome.
Answer: A systemic, immune-mediated reaction that can be fatal or
result in permanent scarring or blindness
,◉ Antagonist.
Answer: A compound that blinds to a receptor that blocks or reduces
the action of another substance at the receptor site
◉ Hyponatremia.
Answer: Common symptoms of this medication side effect include
confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
◉ Therapeutic index.
Answer: ratio of the median toxic dose to the median effective dose
◉ Somnolence.
Answer: Daytime sleepiness
◉ Black Box Warning.
Answer: This warning reflects that a medication may cause a serious
or even life-threatening side effect
◉ Partial or Mixed Agonist.
Answer: A compound that elicits a partial pharmacological response
at the receptor site involved
,◉ Remission.
Answer: The degree of improvement to below the syndromal
threshold of a disorder
◉ Paradoxical.
Answer: A response to a drug that represents the clinical effect
opposite of what is expected
◉ Inverse agonist.
Answer: An agent that binds to the same receptor site as an agonist
but produces the opposite pharmacological effect
◉ 4 major transmitters.
Answer: Dopamine, Serotonin, GABA, Norepinephrine
◉ Dopamine transmitter affects?.
Answer: affects mood, Psychosis, ADHD, Addiction
◉ Serotonin transmitter affects?.
Answer: Depression, aggression, OCD, Panic, GAD, Social Anxiety,
PTSD, Violence, Sexual dysfunction, substance addiction
◉ Norepinephrine affects?.
, Answer: Affects mood, anxiety, psychosis, ADHD (part), drug
withdrawal
◉ GABA affects?.
Answer: Fear, anxiety, worry
◉ Irreversible MAOIs Types.
Answer: MAOa and MAOb
◉ Irreversible MAOIs medications.
Answer: Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
◉ A single dose of MAOIs may persist in its inhibition of MAO for
how long?.
Answer: because they irreversibly inactivate MAOs, the therapeutic
effect of a single dose of irreversible MAOIs may persist for as long
as 2 weeks
◉ What are the most frequent adverse effects of MAOIs?.
Answer: orthostatic hypotension, insomnia, weight gain, edema,
sexual dysfunction
WITH ANSWERS
◉ Agonist (full agonist).
Answer: A drug that binds to a specific receptor producing an effect
identical to that usually produced by the neurotransmitter affecting
that receptor
◉ Pharmacodynamics.
Answer: The time course and intensity of a drug's effect/what the
drug does to the body
◉ Pharmacokinetics.
Answer: What the body does to a drug
◉ Tolerance.
Answer: Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased
sensitivity to adverse effects of a drug
◉ Stevens-Johnson Syndrome.
Answer: A systemic, immune-mediated reaction that can be fatal or
result in permanent scarring or blindness
,◉ Antagonist.
Answer: A compound that blinds to a receptor that blocks or reduces
the action of another substance at the receptor site
◉ Hyponatremia.
Answer: Common symptoms of this medication side effect include
confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
◉ Therapeutic index.
Answer: ratio of the median toxic dose to the median effective dose
◉ Somnolence.
Answer: Daytime sleepiness
◉ Black Box Warning.
Answer: This warning reflects that a medication may cause a serious
or even life-threatening side effect
◉ Partial or Mixed Agonist.
Answer: A compound that elicits a partial pharmacological response
at the receptor site involved
,◉ Remission.
Answer: The degree of improvement to below the syndromal
threshold of a disorder
◉ Paradoxical.
Answer: A response to a drug that represents the clinical effect
opposite of what is expected
◉ Inverse agonist.
Answer: An agent that binds to the same receptor site as an agonist
but produces the opposite pharmacological effect
◉ 4 major transmitters.
Answer: Dopamine, Serotonin, GABA, Norepinephrine
◉ Dopamine transmitter affects?.
Answer: affects mood, Psychosis, ADHD, Addiction
◉ Serotonin transmitter affects?.
Answer: Depression, aggression, OCD, Panic, GAD, Social Anxiety,
PTSD, Violence, Sexual dysfunction, substance addiction
◉ Norepinephrine affects?.
, Answer: Affects mood, anxiety, psychosis, ADHD (part), drug
withdrawal
◉ GABA affects?.
Answer: Fear, anxiety, worry
◉ Irreversible MAOIs Types.
Answer: MAOa and MAOb
◉ Irreversible MAOIs medications.
Answer: Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
◉ A single dose of MAOIs may persist in its inhibition of MAO for
how long?.
Answer: because they irreversibly inactivate MAOs, the therapeutic
effect of a single dose of irreversible MAOIs may persist for as long
as 2 weeks
◉ What are the most frequent adverse effects of MAOIs?.
Answer: orthostatic hypotension, insomnia, weight gain, edema,
sexual dysfunction
