NR507 Midterm Exam 2023 – NR 507 Week 4 Advanced Pathophysiology Midterm Exam Review

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Week 4 Midterm Advanced
Pathophysiology Midterm Exam Latest
Chamberlain College Of
Nursing(VERSION A)

Terms in this set (52)


Type 1: Allergic Reaction
Mediated by IgE
Inflammation due to mast cell degranulation
local symptoms: Itching, rash
Hypersensitivity Type 1
Systemic symptoms: wheezing
Most dangerous form: anaphylactic reaction-systemic
hypotension, severe bronchoconstriction
Main treatment: epinephrine




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Type 2: Cytotoxic, tissue-specific (thyroid tissue)
Primary effector cells: Macrophages
Can cause tissue damage or alter the function
Example: Graves disease (alters thyroid function but does not
Hypersensitivity Type 2
alter tissue)
Example: Incompatible blood type (cell/tissue damage)- Severe
transfusion reaction occurs and the transfused erythrocytes are
destroyed by agglutination or complement-mediated lysis




Type 2: Organ-specific, the antibody binds to an antigen on the
cell surface
Hypersensitivity Type 2 and 3 Type 3: Not organ-specific, the antibody binds to soluble
difference antigen outside the cell surface that was released into the
blood or body fluids and then the complex is distributed into
tissues

Rheumatoid Arthritis: antigen/antibodies are deposited in the
joints
Hypersensitivity Type 3
Systemic Lupus Erythematosus (SLE)- very closely related to
Examples
autoimmunity-antigen/antibodies deposit in organs that cause
tissue damage

rash confined to cheeks (malar rash)
discoid rash (raised, patchy, scaly)
photosensitivity
oral/nasopharyngeal ulcers
Scope of damage of SLE- Type hematologic disorders
3 Hypersensitivity- autoimmune immunologic disorders
response non-erosive arthritis
serositis
renal disorder (proteinuria)
neurologic disorders (seizures)
antinuclear antibody (ANA)



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