Western Governors University D 441
Nursing Pharmacology exam question and correct
solution
Absorption the process by which drug molecules move from their
site of administration to the blood
Affinity the ability of some tissues to attract, accumulate and store
drugs in high concentrations relative to other tissues
blood-brain barrier Blood vessels (capillaries) that selectively let certain
substances enter the brain tissue and keep other
substances out
diffusion process by which molecules tend to move from an area
where they are more concentrated to an area where they
are less
concentrated
distribution the transport of drugs throughout the body after they are
absorbed
drug-protein complexes formed when a drugh that binds reversibly to a plasma
protein, particularly albumin, that makes the drug
unavailable for distribution to its site of action
enterohepatic recirculation recycling of drugs and other substances by the circulation
of bile through the intestine and liver
enzyme induction process by whick a drug increases the activity of the hepatic
microsomal enzymes
excretion the process of removing substances from the body
first-pass effect mechanism whereby drugs are absorbed enter into the
hepatic portal circulation and are inactivated by the liver
before they reach the general circulation
fetal-placental barrier special anatomic barrier that inhibits many chemicals and
drugs from entering the fetus
hepatic microsomal enzyme system as it relates to phamacotherapy, liver enzymes that
metabolize drugs as well as nutrients and other endogenous
substances, sometimes called the P-450 System
isozymes multiple similar forms of an enzyme that perform slightly
different metabolic functions
loading dose relatively large dose of a drug given at the beginning of
treatment to rapidly obtain a therapeutic response
, maintenance doses amount of drug that keeps the plasma drug concentration in
the therapeutic range
Nursing Pharmacology exam question and correct
solution
Absorption the process by which drug molecules move from their
site of administration to the blood
Affinity the ability of some tissues to attract, accumulate and store
drugs in high concentrations relative to other tissues
blood-brain barrier Blood vessels (capillaries) that selectively let certain
substances enter the brain tissue and keep other
substances out
diffusion process by which molecules tend to move from an area
where they are more concentrated to an area where they
are less
concentrated
distribution the transport of drugs throughout the body after they are
absorbed
drug-protein complexes formed when a drugh that binds reversibly to a plasma
protein, particularly albumin, that makes the drug
unavailable for distribution to its site of action
enterohepatic recirculation recycling of drugs and other substances by the circulation
of bile through the intestine and liver
enzyme induction process by whick a drug increases the activity of the hepatic
microsomal enzymes
excretion the process of removing substances from the body
first-pass effect mechanism whereby drugs are absorbed enter into the
hepatic portal circulation and are inactivated by the liver
before they reach the general circulation
fetal-placental barrier special anatomic barrier that inhibits many chemicals and
drugs from entering the fetus
hepatic microsomal enzyme system as it relates to phamacotherapy, liver enzymes that
metabolize drugs as well as nutrients and other endogenous
substances, sometimes called the P-450 System
isozymes multiple similar forms of an enzyme that perform slightly
different metabolic functions
loading dose relatively large dose of a drug given at the beginning of
treatment to rapidly obtain a therapeutic response
, maintenance doses amount of drug that keeps the plasma drug concentration in
the therapeutic range
