NURS 5334 Module 4 Quiz Practice Assessment | 2026/2027 Edition | Page 1
, NURS 5334 PHARMACOLOGY MODULE 4 QUIZ
Advanced Pharmacology for Nurse Practitioners
University of Texas at Arlington (UTA)
100-Question Original Practice Assessment
2026/2027 Edition
Original study assessment aligned to the current Module 4 topic areas.
Women's Health Pharmacology
1. A healthy 24-year-old wants highly effective reversible contraception with minimal daily adherence. Which
option best fits?
A) Male condom alone
B) Combined oral contraceptive taken daily
C) Levonorgestrel-releasing intrauterine system
D) Spermicidal gel alone
Correct Answer: C) Levonorgestrel-releasing intrauterine system
Rationale: A levonorgestrel-releasing intrauterine system is a long-acting reversible contraceptive with very high
effectiveness and no daily adherence requirement. Combined pills can also be effective but depend on consistent
use. Barrier and spermicide-only methods generally have higher typical-use failure rates.
2. Which component of a combined oral contraceptive primarily suppresses follicle-stimulating hormone?
A) Estrogen
B) Progestin only
C) Levonorgestrel emergency contraception only
D) Copper
Correct Answer: A) Estrogen
Rationale: Exogenous estrogen suppresses follicle-stimulating hormone through negative feedback, reducing
follicular development. Progestins mainly suppress the luteinizing-hormone surge and also thicken cervical mucus
and alter the endometrium. The combined effects reduce the likelihood of ovulation and fertilization.
3. Which action is most directly associated with the progestin component of combined hormonal contraception?
A) Increasing follicle-stimulating hormone release
B) Increasing tubal motility
C) Stimulating endometrial proliferation
D) Thickening cervical mucus
Correct Answer: D) Thickening cervical mucus
Rationale: Progestins thicken cervical mucus, making sperm penetration more difficult, and suppress the
luteinizing-hormone surge. They also make the endometrium less favorable for implantation. Estrogen, by
contrast, is the major component responsible for suppressing follicle-stimulating hormone.
4. A patient with migraine with aura requests a combined estrogen-progestin contraceptive. What is the major
concern?
NURS 5334 Module 4 Quiz Practice Assessment | 2026/2027 Edition | Page 2
, A) Severe hypoglycemia
B) Permanent infertility
C) Reduced contraceptive efficacy from aura
D) Increased risk of ischemic stroke
Correct Answer: D) Increased risk of ischemic stroke
Rationale: Estrogen-containing contraception is generally avoided in migraine with aura because of increased
ischemic stroke risk. The concern is thrombotic and vascular rather than reduced contraceptive efficacy. A
progestin-only or nonhormonal method may be more appropriate depending on the patient's full clinical profile.
5. A 38-year-old who smokes one pack per day wants combined oral contraception. Which issue is most
important?
A) Smoking increases folate absorption
B) Estrogen-containing contraception markedly increases cardiovascular risk in smokers over age 35
C) Smoking prevents ovulation
D) Combined pills become ineffective after age 35
Correct Answer: B) Estrogen-containing contraception markedly increases cardiovascular risk in smokers
over age 35
Rationale: Smoking and estrogen-containing contraception have additive cardiovascular and thrombotic risks,
particularly after age 35. This combination is generally avoided. The concern is not that the method suddenly
loses contraceptive efficacy, but that the risk-benefit profile becomes unfavorable.
6. Which adverse effect is most strongly associated with estrogen-containing hormonal contraception?
A) Profound neutropenia
B) Venous thromboembolism
C) Permanent renal failure in healthy users
D) Severe ototoxicity
Correct Answer: B) Venous thromboembolism
Rationale: Estrogen increases hepatic synthesis of several clotting factors and raises venous thromboembolism
risk. Absolute risk remains low in many healthy users, but risk is higher with factors such as prior thrombosis,
smoking, obesity, thrombophilia, or prolonged immobility.
7. A patient taking carbamazepine starts a combined oral contraceptive. What is the main concern?
A) Immediate hyperkalemia
B) Complete suppression of carbamazepine metabolism
C) Excessive estrogen accumulation
D) Reduced contraceptive effectiveness from hepatic enzyme induction
Correct Answer: D) Reduced contraceptive effectiveness from hepatic enzyme induction
Rationale: Carbamazepine induces hepatic enzymes, including CYP3A4, and can accelerate metabolism of
contraceptive steroids. This can reduce hormone concentrations and increase contraceptive failure risk. An
alternative or additional contraceptive method is often appropriate when strong enzyme inducers are used.
NURS 5334 Module 4 Quiz Practice Assessment | 2026/2027 Edition | Page 3
, NURS 5334 PHARMACOLOGY MODULE 4 QUIZ
Advanced Pharmacology for Nurse Practitioners
University of Texas at Arlington (UTA)
100-Question Original Practice Assessment
2026/2027 Edition
Original study assessment aligned to the current Module 4 topic areas.
Women's Health Pharmacology
1. A healthy 24-year-old wants highly effective reversible contraception with minimal daily adherence. Which
option best fits?
A) Male condom alone
B) Combined oral contraceptive taken daily
C) Levonorgestrel-releasing intrauterine system
D) Spermicidal gel alone
Correct Answer: C) Levonorgestrel-releasing intrauterine system
Rationale: A levonorgestrel-releasing intrauterine system is a long-acting reversible contraceptive with very high
effectiveness and no daily adherence requirement. Combined pills can also be effective but depend on consistent
use. Barrier and spermicide-only methods generally have higher typical-use failure rates.
2. Which component of a combined oral contraceptive primarily suppresses follicle-stimulating hormone?
A) Estrogen
B) Progestin only
C) Levonorgestrel emergency contraception only
D) Copper
Correct Answer: A) Estrogen
Rationale: Exogenous estrogen suppresses follicle-stimulating hormone through negative feedback, reducing
follicular development. Progestins mainly suppress the luteinizing-hormone surge and also thicken cervical mucus
and alter the endometrium. The combined effects reduce the likelihood of ovulation and fertilization.
3. Which action is most directly associated with the progestin component of combined hormonal contraception?
A) Increasing follicle-stimulating hormone release
B) Increasing tubal motility
C) Stimulating endometrial proliferation
D) Thickening cervical mucus
Correct Answer: D) Thickening cervical mucus
Rationale: Progestins thicken cervical mucus, making sperm penetration more difficult, and suppress the
luteinizing-hormone surge. They also make the endometrium less favorable for implantation. Estrogen, by
contrast, is the major component responsible for suppressing follicle-stimulating hormone.
4. A patient with migraine with aura requests a combined estrogen-progestin contraceptive. What is the major
concern?
NURS 5334 Module 4 Quiz Practice Assessment | 2026/2027 Edition | Page 2
, A) Severe hypoglycemia
B) Permanent infertility
C) Reduced contraceptive efficacy from aura
D) Increased risk of ischemic stroke
Correct Answer: D) Increased risk of ischemic stroke
Rationale: Estrogen-containing contraception is generally avoided in migraine with aura because of increased
ischemic stroke risk. The concern is thrombotic and vascular rather than reduced contraceptive efficacy. A
progestin-only or nonhormonal method may be more appropriate depending on the patient's full clinical profile.
5. A 38-year-old who smokes one pack per day wants combined oral contraception. Which issue is most
important?
A) Smoking increases folate absorption
B) Estrogen-containing contraception markedly increases cardiovascular risk in smokers over age 35
C) Smoking prevents ovulation
D) Combined pills become ineffective after age 35
Correct Answer: B) Estrogen-containing contraception markedly increases cardiovascular risk in smokers
over age 35
Rationale: Smoking and estrogen-containing contraception have additive cardiovascular and thrombotic risks,
particularly after age 35. This combination is generally avoided. The concern is not that the method suddenly
loses contraceptive efficacy, but that the risk-benefit profile becomes unfavorable.
6. Which adverse effect is most strongly associated with estrogen-containing hormonal contraception?
A) Profound neutropenia
B) Venous thromboembolism
C) Permanent renal failure in healthy users
D) Severe ototoxicity
Correct Answer: B) Venous thromboembolism
Rationale: Estrogen increases hepatic synthesis of several clotting factors and raises venous thromboembolism
risk. Absolute risk remains low in many healthy users, but risk is higher with factors such as prior thrombosis,
smoking, obesity, thrombophilia, or prolonged immobility.
7. A patient taking carbamazepine starts a combined oral contraceptive. What is the main concern?
A) Immediate hyperkalemia
B) Complete suppression of carbamazepine metabolism
C) Excessive estrogen accumulation
D) Reduced contraceptive effectiveness from hepatic enzyme induction
Correct Answer: D) Reduced contraceptive effectiveness from hepatic enzyme induction
Rationale: Carbamazepine induces hepatic enzymes, including CYP3A4, and can accelerate metabolism of
contraceptive steroids. This can reduce hormone concentrations and increase contraceptive failure risk. An
alternative or additional contraceptive method is often appropriate when strong enzyme inducers are used.
NURS 5334 Module 4 Quiz Practice Assessment | 2026/2027 Edition | Page 3
