NCLEX RN Safety and Infection Control
Practice Exam 4 100 Questions And
Correct Answers (Verified Answers)
Plus Rationales 2026 Q&A Instant
Download Pdf
1. A nurse is caring for a client with suspected pulmonary tuberculosis.
Which personal protective equipment (PPE) should the nurse use when
entering the client's room?
A. Surgical mask
B. N95 respirator
C. Face shield only
D. Sterile gloves
Answer: N95 respirator
Rationale: Airborne precautions are required for suspected or confirmed
pulmonary tuberculosis. An appropriately fit-tested N95 respirator or
equivalent respirator protects the nurse from inhaling airborne
Mycobacterium tuberculosis particles.
2. A nurse is preparing to administer medication to a hospitalized client.
Which action is most important for preventing medication errors?
A. Ask another nurse to administer the medication
B. Compare the medication label with the medication administration record
C. Prepare all medications for the entire shift at once
D. Document the medication before administering it
Answer: Compare the medication label with the medication administration
record
,Rationale: Comparing the medication label with the medication
administration record during medication preparation helps ensure the correct
medication, dose, route, and client.
3. A client has Clostridioides difficile infection. Which intervention is
appropriate?
A. Use alcohol-based hand sanitizer after care
B. Place the client on airborne precautions
C. Wash hands with soap and water after removing gloves
D. Use a surgical mask when entering the room
Answer: Wash hands with soap and water after removing gloves
Rationale: C. difficile spores are resistant to alcohol-based hand sanitizers.
Soap and water physically remove spores from the hands. Contact
precautions are also required.
4. Which client should the nurse assess first?
A. Client with a temperature of 38.1°C (100.6°F) after surgery
B. Client requesting assistance with bathing
C. Client with new confusion and oxygen saturation of 86%
D. Client reporting pain of 6/10
Answer: Client with new confusion and oxygen saturation of 86%
Rationale: Hypoxemia can rapidly become life-threatening. New confusion
may be a sign of inadequate oxygenation, so this client requires immediate
assessment and intervention.
5. A nurse is caring for a client at high risk for falls. Which intervention is
appropriate?
A. Keep all four side rails raised
B. Place the call light within reach
C. Keep the bed in the highest position
D. Encourage the client to walk independently
Answer: Place the call light within reach
,Rationale: Keeping the call light accessible promotes safe assistance. Four
side rails may be considered a restraint, and the bed should generally be
maintained in a low position.
6. A client receiving a blood transfusion develops chills, fever, and back
pain. What is the nurse's priority action?
A. Slow the transfusion
B. Stop the transfusion
C. Administer acetaminophen
D. Obtain another unit of blood
Answer: Stop the transfusion
Rationale: Fever, chills, and back pain may indicate an acute hemolytic
transfusion reaction. The transfusion must be stopped immediately, and the
nurse should maintain IV access with appropriate compatible solution
according to facility policy and notify the provider and blood bank.
7. Which action by a nurse demonstrates proper infection-control
technique?
A. Wearing the same gloves between clients
B. Reusing a disposable syringe for the same client
C. Performing hand hygiene before and after client contact
D. Wearing a gown for every client regardless of precautions
Answer: Performing hand hygiene before and after client contact
Rationale: Hand hygiene is one of the most effective measures for preventing
transmission of infection between clients and healthcare workers.
8. A nurse discovers a fire in a client's room. What should the nurse do
first?
A. Extinguish the fire
B. Close all unit doors
C. Remove the client from immediate danger
D. Activate the sprinkler system
Answer: Remove the client from immediate danger
, Rationale: During a fire, the priority is to rescue anyone in immediate danger.
The nurse then activates the alarm and follows the facility's fire-response
procedures.
9. Which action is appropriate when using a fire extinguisher?
A. PASS: Pull, Aim, Squeeze, Sweep
B. PUSH: Pull, Use, Spray, Hold
C. RACE: Rescue, Alarm, Confine, Extinguish
D. SAFE: Secure, Alert, Fight, Evacuate
Answer: PASS: Pull, Aim, Squeeze, Sweep
Rationale: PASS is the standard sequence for operating many fire
extinguishers: pull the pin, aim at the base of the fire, squeeze the handle,
and sweep from side to side.
10.A nurse is caring for a client with neutropenia. Which intervention is
most appropriate?
A. Place fresh flowers in the client's room
B. Encourage visitors with recent respiratory infections to visit
C. Monitor the client closely for signs of infection
D. Serve raw fruits and vegetables without washing them
Answer: Monitor the client closely for signs of infection
Rationale: Neutropenic clients have impaired defenses against infection. Care
focuses on reducing exposure to pathogens and promptly identifying
infection.
11.A nurse accidentally sustains a needlestick injury. What should the nurse
do first?
A. Complete an incident report
B. Wash the area with soap and water
C. Call the client's family
D. Wait for symptoms to develop
Answer: Wash the area with soap and water
Practice Exam 4 100 Questions And
Correct Answers (Verified Answers)
Plus Rationales 2026 Q&A Instant
Download Pdf
1. A nurse is caring for a client with suspected pulmonary tuberculosis.
Which personal protective equipment (PPE) should the nurse use when
entering the client's room?
A. Surgical mask
B. N95 respirator
C. Face shield only
D. Sterile gloves
Answer: N95 respirator
Rationale: Airborne precautions are required for suspected or confirmed
pulmonary tuberculosis. An appropriately fit-tested N95 respirator or
equivalent respirator protects the nurse from inhaling airborne
Mycobacterium tuberculosis particles.
2. A nurse is preparing to administer medication to a hospitalized client.
Which action is most important for preventing medication errors?
A. Ask another nurse to administer the medication
B. Compare the medication label with the medication administration record
C. Prepare all medications for the entire shift at once
D. Document the medication before administering it
Answer: Compare the medication label with the medication administration
record
,Rationale: Comparing the medication label with the medication
administration record during medication preparation helps ensure the correct
medication, dose, route, and client.
3. A client has Clostridioides difficile infection. Which intervention is
appropriate?
A. Use alcohol-based hand sanitizer after care
B. Place the client on airborne precautions
C. Wash hands with soap and water after removing gloves
D. Use a surgical mask when entering the room
Answer: Wash hands with soap and water after removing gloves
Rationale: C. difficile spores are resistant to alcohol-based hand sanitizers.
Soap and water physically remove spores from the hands. Contact
precautions are also required.
4. Which client should the nurse assess first?
A. Client with a temperature of 38.1°C (100.6°F) after surgery
B. Client requesting assistance with bathing
C. Client with new confusion and oxygen saturation of 86%
D. Client reporting pain of 6/10
Answer: Client with new confusion and oxygen saturation of 86%
Rationale: Hypoxemia can rapidly become life-threatening. New confusion
may be a sign of inadequate oxygenation, so this client requires immediate
assessment and intervention.
5. A nurse is caring for a client at high risk for falls. Which intervention is
appropriate?
A. Keep all four side rails raised
B. Place the call light within reach
C. Keep the bed in the highest position
D. Encourage the client to walk independently
Answer: Place the call light within reach
,Rationale: Keeping the call light accessible promotes safe assistance. Four
side rails may be considered a restraint, and the bed should generally be
maintained in a low position.
6. A client receiving a blood transfusion develops chills, fever, and back
pain. What is the nurse's priority action?
A. Slow the transfusion
B. Stop the transfusion
C. Administer acetaminophen
D. Obtain another unit of blood
Answer: Stop the transfusion
Rationale: Fever, chills, and back pain may indicate an acute hemolytic
transfusion reaction. The transfusion must be stopped immediately, and the
nurse should maintain IV access with appropriate compatible solution
according to facility policy and notify the provider and blood bank.
7. Which action by a nurse demonstrates proper infection-control
technique?
A. Wearing the same gloves between clients
B. Reusing a disposable syringe for the same client
C. Performing hand hygiene before and after client contact
D. Wearing a gown for every client regardless of precautions
Answer: Performing hand hygiene before and after client contact
Rationale: Hand hygiene is one of the most effective measures for preventing
transmission of infection between clients and healthcare workers.
8. A nurse discovers a fire in a client's room. What should the nurse do
first?
A. Extinguish the fire
B. Close all unit doors
C. Remove the client from immediate danger
D. Activate the sprinkler system
Answer: Remove the client from immediate danger
, Rationale: During a fire, the priority is to rescue anyone in immediate danger.
The nurse then activates the alarm and follows the facility's fire-response
procedures.
9. Which action is appropriate when using a fire extinguisher?
A. PASS: Pull, Aim, Squeeze, Sweep
B. PUSH: Pull, Use, Spray, Hold
C. RACE: Rescue, Alarm, Confine, Extinguish
D. SAFE: Secure, Alert, Fight, Evacuate
Answer: PASS: Pull, Aim, Squeeze, Sweep
Rationale: PASS is the standard sequence for operating many fire
extinguishers: pull the pin, aim at the base of the fire, squeeze the handle,
and sweep from side to side.
10.A nurse is caring for a client with neutropenia. Which intervention is
most appropriate?
A. Place fresh flowers in the client's room
B. Encourage visitors with recent respiratory infections to visit
C. Monitor the client closely for signs of infection
D. Serve raw fruits and vegetables without washing them
Answer: Monitor the client closely for signs of infection
Rationale: Neutropenic clients have impaired defenses against infection. Care
focuses on reducing exposure to pathogens and promptly identifying
infection.
11.A nurse accidentally sustains a needlestick injury. What should the nurse
do first?
A. Complete an incident report
B. Wash the area with soap and water
C. Call the client's family
D. Wait for symptoms to develop
Answer: Wash the area with soap and water
