Lehne's Pharmacology
Exam 1 Ch 1-6
Practice Questions &
Answers
Comprehensive Explanations
& Rationales
Key Concepts • Review
Questions • Exam Preparation
, Pharmacokinetics The process by which drugs are absorbed, distributed , metabolized, and excreted.
Absorption determines intensity & time of the effects
3 ways to cross a cell membrane - channels and pores(electrolytes/ions)
- transport systems (P-glycoprotein)
- direct penetration of the membrane(lipid soluble)
blood-brain barrier Blood vessels (capillaries) that selectively let certain substances enter the brain
tissue and keep other substances out
Routes of Drug Administration: Parenteral-(via injection)
Intravenous, intramuscular, subcutaneous (SC)
Enteral/Oral- by mouth
drug metabolization structural enzyme change
P450 system (cytochrome P450) ox enzymes: detoxify, improves solubility to be exc by kidneys (12 enzyme families)
What enzymes of Cytochrome P450 metabolize drugs? CYP 1,2,3
Exam 1 Ch 1-6
Practice Questions &
Answers
Comprehensive Explanations
& Rationales
Key Concepts • Review
Questions • Exam Preparation
, Pharmacokinetics The process by which drugs are absorbed, distributed , metabolized, and excreted.
Absorption determines intensity & time of the effects
3 ways to cross a cell membrane - channels and pores(electrolytes/ions)
- transport systems (P-glycoprotein)
- direct penetration of the membrane(lipid soluble)
blood-brain barrier Blood vessels (capillaries) that selectively let certain substances enter the brain
tissue and keep other substances out
Routes of Drug Administration: Parenteral-(via injection)
Intravenous, intramuscular, subcutaneous (SC)
Enteral/Oral- by mouth
drug metabolization structural enzyme change
P450 system (cytochrome P450) ox enzymes: detoxify, improves solubility to be exc by kidneys (12 enzyme families)
What enzymes of Cytochrome P450 metabolize drugs? CYP 1,2,3
