NUR2407 / NUR 2407: Pharmacology Exam 1 Test UPDATED ACTUAL Exam Questions and CORRECT Answers

NUR2407 / NUR 2407: Pharmacology Exam 1 Test
UPDATED ACTUAL Exam Questions and CORRECT Answers

Question 1.
pharmacodynamics

Correct Answer: relationship between drug concentration over time and
therapeutic response


Question 2.
chemical specificity for receptors

Correct Answer: specificity between receptors and bonds, EX strict structural
requirements for binding


Question 3.
receptor saturability

Correct Answer: only a finite number of receptors that can be occupied


Question 4.
receptor affinity

Correct Answer: measure of attraction between drug and receptor


Question 5.
drug potency

Correct Answer: dose required to have certain effect, related to affinity of
receptor


Question 6.
ED50

Correct Answer: dose which produces 50% of maximum effect, used to
compare drugs in terms of potency


Question 7.
drug efficacy

Correct Answer: maximal effect achievable for a drug, related to number of
receptor/complexes formed, intrinsic activity of drug in activating receptor

,Question 8.
full agonist

Correct Answer: affinity to, and full activator, of receptor (high intrinsic
activity/efficacy), increases activity above basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the absence of a
ligand


Question 9.
inverse agonist

Correct Answer: affinity to, and full activator of receptor (high intrinsic
activity/efficacy), but has exact opposite effect of full agonist (metoprolol),
decreases activity below basal level of receptor where receptor has a
constitutive (intrinsic basal) level of activity in the absence of a ligand


Question 10.
partial agonist

Correct Answer: affinity to receptor but only partially activates a receptor,
produces less than the ceiling effect of a full agonist
• pure antagonist -✓✓affinity to receptor but produces no activation, dose
curve is a straight line across the bottom of an XY graph (EX oraverse
vasodilates, overcoming the vasocontriction of the LA)


Question 11.
neutral antgonist

Correct Answer: has no activity in the absence of an agonist or inverse agonist
but can block either's activity


Question 12.
competitive antagonist

Correct Answer: lacks efficacy, competes with agonists for binding sites,
inhibitory effect can be overcome by increasing concentration of competing
agonist


Question 13.
every drug produces a variety of effects, we hope we can get separation from things we
want and adverse side effects, this is different for every patient

Correct Answer:

, Question 14.
know the second slide on page 10 of principles of drugs

Correct Answer: which drugs is most potent, least potenet, most efficient and
least efficient


Question 15.
physiological antagonism

Correct Answer: stimulates competing/opposite physiological responses which
counteract the effects of a therapeutic drug, the inhibitory effect can *NOT*
be overcome by increasing the agonist dosage (EX epi is used during
anaphylaxis to produce physiological responses instead of an antihistamine
which is only a competing antagonist)


Question 16.
exam will ask you to explain interactions between drugs in reference to physiological
antagonism that were explained in lectures

Correct Answer:


Question 17.
therapeutic index

Correct Answer: the difference between a dose that produces a therapeutic
effect and a dose that produces a lethal toxicity, this has to do with a
population


Question 18.
which drug is a safer drug? a drug with a therapeutic index of 2 or therapeutic index of
10

Correct Answer: the therapeutic index of 10 is safer, there is a larger range of
dosages we can give without toxicity


Question 19.
therapeutic window

Correct Answer: difference between ineffective and effective dose range,
drugs like penicillin has a large window where others have a small one (more
dangerous), some DDIs happen to decrease or increase metabolism/reception
of the drug and therefore increase or decrease plasma conc. causing toxicity
or ineffectiveness depending on the type of DDI