NR 565 Pharmacology Week 4 – Nursing Study Guide & Notes

NR,/.565,/.Pharmacology,/.Week,/.4


Most,/.common,/.inflammatory,/.form,/.of,/.arthritis,/.-,/.correct,/.answer,/.✔ ✔
Gout



Characteristics:,/.RA,/.-,/.correct,/.answer,/.✔ ✔ Rapid,/.onset

3:1,/.in,/.women/men
Age,/.35-50,/.years,/.at,/.onset
Affects,/.hands,/.and,/.feet
local,/.and,/.systemic,/.inflammation
60,/.mins,/.morning,/.joint,/.stiffness
Symmetric,/.
Elevated,/.ESR
Leukocytosis
Systemic,/.symptoms



RA,/.symptoms,/.-,/.correct,/.answer,/.✔ ✔ Pain

Swelling
Warmth
Stiffness

,Characteristics:,/.Osteoarthritis,/.-,/.correct,/.answer,/.✔ ✔
Slow,/.onset,/.(years)
1:1,/.in,/.men/women
Age,/.>,/.50,/.years,/.at,/.onset
Affects,/.hands,,/.hips,,/.knees
Mild,/.or,/.local,/.inflammation
<,/.30,/.min,/.morning,/.joint,/.stiffness
symmetric,/.or,/.asymmetric,/.pattern
ESR,/.normal
Mild,/.leukocytosis
No,/.systemic,/.symptoms



Symptoms:,/.Osteoarthritis,/.-,/.correct,/.answer,/.✔ ✔ Pain

Bone,/.enlargement



Treatment,/.goals:,/.RA,/.-,/.correct,/.answer,/.✔ ✔ Relieve,/.symptoms

Maintain,/.joint,/.function,/.and,/.ROM
Decrease,/.systemic,/.involvement
Delay,/.disease,/.progression


Medications:,/.RA,/.-,/.correct,/.answer,/.✔ ✔ NSAIDS

, Glucocorticoids
Conventional,/.DMARDS
Biologic,/.DMARDS



Mechanism,/.of,/.action:,/.Conventional,/.DMARDs,/.-,/.correct,/.answer,/.✔ ✔
Immunosuppressant
Inhibits,/.dihydrofolate,/.reductase
Inhibits,/.lymphocyte,/.proliferation
Folate,/.antagonist


Mechanism,/.of,/.action:,/.Bioloic,/.DMARDs,/.-,/.correct,/.answer,/.✔ ✔
Inhibits,/.JAK,/.1,2,3,/.=,/.disruption,/.of,/.cytokine,/.and,/.growth,/.factor,/.signali
ng,/.pathways


Mechanism,/.of,/.action:,/.Targeted,/.DMARDs,/.-,/.correct,/.answer,/.✔ ✔
Binds,/.to,/.and,/.inhibits,/.tumor,/.necrosis,/.factor,/.alpha,/.=,/.decreased,/.inflam
mation,/.and,/.altered,/.immune,/.response



Medications:,/.Conventional,/.DMARDs,/.-,/.correct,/.answer,/.✔ ✔
Methotrexate
Sulfasalazine,/.(azulfidine)
Leflunomide,/.(arava)