MICR 3230 Exam (IMMUNOLOGY)
Questions with Correct and Verified
Answers 2026/2027 Edition.
What cells are MHC Class I molecules found on? - Answer all nucleated cells
What cells are MHC Class II molecules found on? - Answer antigen presenting cells (high
expressed on B cells and DC's and low expression on macrophages)
MHC Class I molecules are recognized by...? - Answer cytotoxic T cells
MHC Class II molecules are recognized by...? - Answer helper T cells
What molecule stabilizes MHC Class I? - Answer CD8
What molecule stabilizes MHC Class II? - Answer CD4
Agretope - Answer the fragment of the antigen that is recognized by the MHC molecule
Epitope - Answer the fragment of the antigen that is recognized by the T cell receptor
Nomenclature of mice MHC system - Answer H-2 complex
What chromosome are the MHC genes found on in mice? - Answer Chromosome 17
Nomenclature of human MHC system - Answer HLA complex
What chromosome are the MHC genes found on in humans? - Answer Chromosome 6
relative risk= - Answer [frequency of + allele in diseased population/frequency of - allele in
diseased population] / [frequency of + allele in healthy population/frequency of - allele in
healthy population]
RR=1 - Answer there is no relative risk associated with the allel
,True/False: MHC molecules are part of the immunoglobulin superfamily - Answer true
True/False: MHC molecules have a transmembrane section and a cytoplasmic tail - Answer
true
What forms the peptide-binding groove in MHC Class I molecules? - Answer alpha 1 and alpha
2 domains
What forms the peptide-binding groove in MHC Class II molecules - Answer alpha 1 and beta 1
domains
polymorphism - Answer genetic variation observed within the MHC molecules
Which molecule is a heterodimer? - Answer MHC Class II
What does the alpha-3 domain do in MHC Class I molecules? - Answer binds to the cytotoxic T
cell
What does the alpha-2 domain do in MHC Class II molecules? - Answer binds to the helper T
cell
Does beta-2 microglobulin insert itself into the plasma membrane? - Answer no
True/False: the beta-2 microglobulin genes are encoded within the MHC gene region - Answer
false
Which molecule has a closed binding groove? - Answer MHC Class I
Which molecule has an open binding groove? - Answer MHC Class II
How do peptides fit inside of MHC Class I molecules? - Answer peptide arches up and away
from the molecule
How doe peptides fit inside of MHC Class II molecules? - Answer peptide lays flat on the
molecule
How many amino acids fit in the MHC Class I peptide binding groove? - Answer 8-10
, How many amino acids fit in the MHC Class II peptide binding groove? - Answer 13-18
Structure of MHC genes in mice: - Answer I-->K-->H-2K
II-->IA and IE-->IA alpha-beta and IE alpha-beta
III-->S-->complement proteins and TNF-alpha
I-->D-->H-2D and H-2L
Structure of MHC genes in humans: - Answer II-->DP,DQ,DR-->DP alpha-beta, DQ alpha-beta,
DR alpha-beta
III-->c4,c2,BF-->complement proteins and TNF-alpha
I-->B,C,A-->HLA-B, HLA-C,HLA-A
True/False: MHC Class III molecules play some role in antigen presentation - Answer false
How are MHC molecules inherited? - Answer classic Mendelian genetics with MHC molecules
being inherited as a haplotype
True/False: MHC molecules have a low recombination frequency (~0.5%) - Answer true
syngeneic mice: - Answer are identical at all loci
congenic mice: - Answer differ at a single genetic locus
exon/intron arrangement for MHC Class I molecules: - Answer 5' leader exon for signal peptide
followed by 5-6 exons encoding the alpha chain
True/False: MHC polymorphism is derived by VDJ joining - Answer false
exon/intron arrangement for MHC Class II molecules: - Answer alpha and beta genes have
leader exons followed by extracellular domain exons then transmembrane and cytoplasmic
exons
Why is the recombination of MHC molecules so low? - Answer because the genes are tightly
linked to each other
What are the MHC Class I allelic variants? - Answer a-g
Questions with Correct and Verified
Answers 2026/2027 Edition.
What cells are MHC Class I molecules found on? - Answer all nucleated cells
What cells are MHC Class II molecules found on? - Answer antigen presenting cells (high
expressed on B cells and DC's and low expression on macrophages)
MHC Class I molecules are recognized by...? - Answer cytotoxic T cells
MHC Class II molecules are recognized by...? - Answer helper T cells
What molecule stabilizes MHC Class I? - Answer CD8
What molecule stabilizes MHC Class II? - Answer CD4
Agretope - Answer the fragment of the antigen that is recognized by the MHC molecule
Epitope - Answer the fragment of the antigen that is recognized by the T cell receptor
Nomenclature of mice MHC system - Answer H-2 complex
What chromosome are the MHC genes found on in mice? - Answer Chromosome 17
Nomenclature of human MHC system - Answer HLA complex
What chromosome are the MHC genes found on in humans? - Answer Chromosome 6
relative risk= - Answer [frequency of + allele in diseased population/frequency of - allele in
diseased population] / [frequency of + allele in healthy population/frequency of - allele in
healthy population]
RR=1 - Answer there is no relative risk associated with the allel
,True/False: MHC molecules are part of the immunoglobulin superfamily - Answer true
True/False: MHC molecules have a transmembrane section and a cytoplasmic tail - Answer
true
What forms the peptide-binding groove in MHC Class I molecules? - Answer alpha 1 and alpha
2 domains
What forms the peptide-binding groove in MHC Class II molecules - Answer alpha 1 and beta 1
domains
polymorphism - Answer genetic variation observed within the MHC molecules
Which molecule is a heterodimer? - Answer MHC Class II
What does the alpha-3 domain do in MHC Class I molecules? - Answer binds to the cytotoxic T
cell
What does the alpha-2 domain do in MHC Class II molecules? - Answer binds to the helper T
cell
Does beta-2 microglobulin insert itself into the plasma membrane? - Answer no
True/False: the beta-2 microglobulin genes are encoded within the MHC gene region - Answer
false
Which molecule has a closed binding groove? - Answer MHC Class I
Which molecule has an open binding groove? - Answer MHC Class II
How do peptides fit inside of MHC Class I molecules? - Answer peptide arches up and away
from the molecule
How doe peptides fit inside of MHC Class II molecules? - Answer peptide lays flat on the
molecule
How many amino acids fit in the MHC Class I peptide binding groove? - Answer 8-10
, How many amino acids fit in the MHC Class II peptide binding groove? - Answer 13-18
Structure of MHC genes in mice: - Answer I-->K-->H-2K
II-->IA and IE-->IA alpha-beta and IE alpha-beta
III-->S-->complement proteins and TNF-alpha
I-->D-->H-2D and H-2L
Structure of MHC genes in humans: - Answer II-->DP,DQ,DR-->DP alpha-beta, DQ alpha-beta,
DR alpha-beta
III-->c4,c2,BF-->complement proteins and TNF-alpha
I-->B,C,A-->HLA-B, HLA-C,HLA-A
True/False: MHC Class III molecules play some role in antigen presentation - Answer false
How are MHC molecules inherited? - Answer classic Mendelian genetics with MHC molecules
being inherited as a haplotype
True/False: MHC molecules have a low recombination frequency (~0.5%) - Answer true
syngeneic mice: - Answer are identical at all loci
congenic mice: - Answer differ at a single genetic locus
exon/intron arrangement for MHC Class I molecules: - Answer 5' leader exon for signal peptide
followed by 5-6 exons encoding the alpha chain
True/False: MHC polymorphism is derived by VDJ joining - Answer false
exon/intron arrangement for MHC Class II molecules: - Answer alpha and beta genes have
leader exons followed by extracellular domain exons then transmembrane and cytoplasmic
exons
Why is the recombination of MHC molecules so low? - Answer because the genes are tightly
linked to each other
What are the MHC Class I allelic variants? - Answer a-g
