Immunology Exam Practice Questions
and All Correct Answers 2026/2027
Updated.
T/F - Monocytes can phagocytose/engulf invading pathogens and cause their lysis and
degradation - Answer True
MC - Secondary lymphoid organ areas include:
Bone marrow
Thymus
Lymph nodes and spleen
Skin - Answer Lymph nodes and spleen
MC - CD4 molecules are most commonly found on _______ while CD8 molecules are most
commonly found on ________.
T-helper cells, T-cytotoxic cells
B cells, T-cytotoxic cells
B cells, T-helper cells
T-cytotoxic cells, T-helper cells - Answer T-helper cells, T-cytotoxic cells
T/F - Upon first exposure to a pathogen the adaptive immune response will respond more
quickly than the innate immune response. - Answer False
MC - Lymphoid progenitors do NOT give rise to which cell type?
T-cell progenitors
Dendritic cells
Macrophages
Innate lymphoid cells - Answer Macrophages
MC - The toll-like receptor signaling cascade is an example of a:
Pathogen-associated molecular pattern (PAMP)
Macrophage
Cytokine
Pattern recognition receptor (PRR) - Answer Pattern recognition receptor (PRR)
, T/F - Neutrophils release enzymes and antimicrobial peptides during immune response - Answer
True
MC - Thymocytes are immature T cells and if the T cell receptor (TCR) binds with too high
affinity to self-MHC/peptide complexes the cells are induced to die. This is an example of:
negative selection
does not happen
positive selection
clonal expansion - Answer Negative selection
MC - Which of the following describes the concept of humoral immunity?
Involves primarily T lymphocytes
Is not real
A synonym for cell-mediated immunity
Involves primarily B cells and antibodies - Answer Involves primarily B cells and antibodies
MC - Which of the following is an example of an antimicrobial protein?
Dermcidin
Granulocytes
Toll-like receptors
Lactoferrin - Answer Lactoferrin
MC - NK cells:
Are Large Granular Lymphoid Cells derived from precursors in the bone marrow
Do not require the thymus for development
Do not undergo receptor gene rearrangements
All of the above
None of the above - Answer All of the above
T/F - The thymus selects for maturation of only those T cells whose receptors recognize antigen
on cells with self-MHC - Answer True
MC - The missing self model refers to:
Lack of MHC on APCs as a signal for NK cells to kill their target
Lack of killing by T cells when foreign MHC molecules are recognized on APCs
Lack of NK cell receptors that recognize specific antigenic epitopes on APCs
and All Correct Answers 2026/2027
Updated.
T/F - Monocytes can phagocytose/engulf invading pathogens and cause their lysis and
degradation - Answer True
MC - Secondary lymphoid organ areas include:
Bone marrow
Thymus
Lymph nodes and spleen
Skin - Answer Lymph nodes and spleen
MC - CD4 molecules are most commonly found on _______ while CD8 molecules are most
commonly found on ________.
T-helper cells, T-cytotoxic cells
B cells, T-cytotoxic cells
B cells, T-helper cells
T-cytotoxic cells, T-helper cells - Answer T-helper cells, T-cytotoxic cells
T/F - Upon first exposure to a pathogen the adaptive immune response will respond more
quickly than the innate immune response. - Answer False
MC - Lymphoid progenitors do NOT give rise to which cell type?
T-cell progenitors
Dendritic cells
Macrophages
Innate lymphoid cells - Answer Macrophages
MC - The toll-like receptor signaling cascade is an example of a:
Pathogen-associated molecular pattern (PAMP)
Macrophage
Cytokine
Pattern recognition receptor (PRR) - Answer Pattern recognition receptor (PRR)
, T/F - Neutrophils release enzymes and antimicrobial peptides during immune response - Answer
True
MC - Thymocytes are immature T cells and if the T cell receptor (TCR) binds with too high
affinity to self-MHC/peptide complexes the cells are induced to die. This is an example of:
negative selection
does not happen
positive selection
clonal expansion - Answer Negative selection
MC - Which of the following describes the concept of humoral immunity?
Involves primarily T lymphocytes
Is not real
A synonym for cell-mediated immunity
Involves primarily B cells and antibodies - Answer Involves primarily B cells and antibodies
MC - Which of the following is an example of an antimicrobial protein?
Dermcidin
Granulocytes
Toll-like receptors
Lactoferrin - Answer Lactoferrin
MC - NK cells:
Are Large Granular Lymphoid Cells derived from precursors in the bone marrow
Do not require the thymus for development
Do not undergo receptor gene rearrangements
All of the above
None of the above - Answer All of the above
T/F - The thymus selects for maturation of only those T cells whose receptors recognize antigen
on cells with self-MHC - Answer True
MC - The missing self model refers to:
Lack of MHC on APCs as a signal for NK cells to kill their target
Lack of killing by T cells when foreign MHC molecules are recognized on APCs
Lack of NK cell receptors that recognize specific antigenic epitopes on APCs
