Exam Practice Question Bank —
300 Questions with Answers
and Rationales
1. A 58-year-old male with COPD is brought to the ED with worsening
dyspnea. ABG on 2 L/min nasal cannula: pH 7.31, PaCO₂ 68, PaO₂ 55, HCO₃⁻
32. What is the primary acid-base disorder?
A) Acute respiratory acidosis
B) Chronic respiratory acidosis
C) Acute on chronic respiratory acidosis
D) Metabolic alkalosis
Answer: C
Rationale: PaCO₂ >45 = respiratory acidosis. Elevated HCO₃⁻ (32) indicates
renal compensation. pH 7.31 (<7.35) shows an acute component.
2. A 34-year-old asthmatic has peak flow 180 L/min (predicted 450). After 3
albuterol nebulizers, peak flow is 210 L/min. What is the percent
improvement?
A) 12%
B) 14%
C) 16.7%
,D) 20%
Answer: C
Rationale: (210−180)/180 × 100 = 30/180 × 100 = 16.7%. <12% indicates
poor response; 16.7% is minimal but positive.
3. Which of the following is the BEST indicator of hypoventilation in a
spontaneously breathing patient?
A) PaO₂ 60 mmHg
B) PaCO₂ 55 mmHg
C) SaO₂ 88%
D) pH 7.32
Answer: B
Rationale: PaCO₂ directly measures alveolar ventilation. >45 mmHg =
hypoventilation regardless of O₂.
4. A patient post-cardiac arrest has ETCO₂ 22 mmHg on capnography. What is
the most likely interpretation?
A) Hyperventilation
B) Hypoventilation
C) Normal ventilation
D) Pulmonary embolism
,Answer: A
Rationale: Normal ETCO₂ 35–45 mmHg. <35 = hyperventilation or low
cardiac output. Here, hyperventilation is most likely.
5. A 72-year-old female with pneumonia has a P/F ratio of 180. This indicates:
A) Mild ARDS
B) Moderate ARDS
C) Severe ARDS
D) No ARDS
Answer: B
Rationale: Berlin criteria: Mild 200–300, Moderate 100–200, Severe <100. P/F
180 = moderate ARDS.
6. You auscultate bronchial breath sounds over the right lower lobe. This
suggests:
A) Normal lung
B) Consolidation
C) Pleural effusion
D) Pneumothorax
Answer: B
, Rationale: Bronchial breath sounds normally heard over trachea. Over
peripheral lung = consolidation (transmitted from central airways).
7. A patient has a pH of 7.28, PaCO₂ of 50 mmHg, and HCO₃⁻ of 24 mEq/L.
What is the primary acid-base disorder?
A) Respiratory acidosis
B) Respiratory alkalosis
C) Metabolic acidosis
D) Metabolic alkalosis
Answer: A
Rationale: Low pH with elevated PaCO₂ indicates acute respiratory acidosis.
8. A patient has a pH of 7.48, PaCO₂ of 32 mmHg, and HCO₃⁻ of 23 mEq/L.
What is the primary acid-base disorder?
A) Respiratory acidosis
B) Respiratory alkalosis
C) Metabolic acidosis
D) Metabolic alkalosis
Answer: B
Rationale: Elevated pH with low PaCO₂ indicates respiratory alkalosis.