NR565 Final Exam Review Questions with
Verified Correct Answers
Biguanides Prototype Drug
metformin (Glucophage)
Radioactive Iodine Adverse Effects (3)
significant incidence of delayed hypothyroidism
risk of cancer in young patients
contraindicated in pregnancy and lactation
Methimazole indications
thyrotoxic crisis
Methimazole MOA
blocks thyroid peroxidase which is involved in synthesis of T3 and T4 but does not impact
existing thyroid hormone stores
levothyroxine (Synthroid) Education (3)
take on empty stomach 30-60min before breakfast
consistency of timing
avoid Ca, Mag, Fe within 4 hrs of drug
levothyroxine (Synthroid) Population Considerations
Cardiovascular d/o d/t potential to increase HR and BP
levothyroxine (Synthroid) Monitoring
Thyroid function labs: 6-8 weeks after initiation of therapy and yearly after achieving euthyroid
levothyroxine (Synthroid) Drug Interactions (5)
, Ca, Mag, Fe decrease absorption
seizure and BH drugs increase metabolism
enhance anticoagulant effects of warfarin by accelerating degradation of vitamin K dependent
clotting factors
increased risk of arrhythmias with catecholamines
increase requirements of insulin and digoxin
Levothyroxine (Synthroid) Dosing
PO 50-60mcg
IV (myxedema coma)
Levothyroxine (Synthroid) Adjustment
Goal TSH 0.5 - 2microunits/mL
Pioglitazone (Actos) contraindications (2)
severe HF d/t fluid retention
Hx of bladder CA
insulin detemir dosing
40-50% total daily insulin requirement
insulin Basal dosing
T1DM: 0.5-0.6 units/kg/day
T2DM: 0.2-0.6 units/kg/day
levemir duration (2)
0.2units/kg = 12hrs
0.4units/kg = 20-24hrs
ADA Guidelines (5)
Step 1: At time of diagnosis: lifestyle change in combination with metformin (Glucophage)
Step2: Add GLP-1 receptor agonist or basal insulin
Verified Correct Answers
Biguanides Prototype Drug
metformin (Glucophage)
Radioactive Iodine Adverse Effects (3)
significant incidence of delayed hypothyroidism
risk of cancer in young patients
contraindicated in pregnancy and lactation
Methimazole indications
thyrotoxic crisis
Methimazole MOA
blocks thyroid peroxidase which is involved in synthesis of T3 and T4 but does not impact
existing thyroid hormone stores
levothyroxine (Synthroid) Education (3)
take on empty stomach 30-60min before breakfast
consistency of timing
avoid Ca, Mag, Fe within 4 hrs of drug
levothyroxine (Synthroid) Population Considerations
Cardiovascular d/o d/t potential to increase HR and BP
levothyroxine (Synthroid) Monitoring
Thyroid function labs: 6-8 weeks after initiation of therapy and yearly after achieving euthyroid
levothyroxine (Synthroid) Drug Interactions (5)
, Ca, Mag, Fe decrease absorption
seizure and BH drugs increase metabolism
enhance anticoagulant effects of warfarin by accelerating degradation of vitamin K dependent
clotting factors
increased risk of arrhythmias with catecholamines
increase requirements of insulin and digoxin
Levothyroxine (Synthroid) Dosing
PO 50-60mcg
IV (myxedema coma)
Levothyroxine (Synthroid) Adjustment
Goal TSH 0.5 - 2microunits/mL
Pioglitazone (Actos) contraindications (2)
severe HF d/t fluid retention
Hx of bladder CA
insulin detemir dosing
40-50% total daily insulin requirement
insulin Basal dosing
T1DM: 0.5-0.6 units/kg/day
T2DM: 0.2-0.6 units/kg/day
levemir duration (2)
0.2units/kg = 12hrs
0.4units/kg = 20-24hrs
ADA Guidelines (5)
Step 1: At time of diagnosis: lifestyle change in combination with metformin (Glucophage)
Step2: Add GLP-1 receptor agonist or basal insulin
