NAPLEX Asthma Questions with Correct Answers (Grade A+)
Question 1: Asthma is characterized by -
Answer: chronic airway inflammation and bronchoconstriction; reversible expiratory airflow limitation
Question 2: How is asthma diagnosed?
Answer: FEV1 increases by >12% post-bronchodilator
Question 3: What vaccines are recommended in asthma?
Answer: annual flu; pneumococcal
Question 4: When should allergy testing be done in asthma?
Answer: persistent symptoms and allergen association
Question 5: What is the preferred reliever in asthma?
Answer: ICS/formoterol or SABA + ICS
Question 6: formoterol MOA
Answer: LABA with fast onset
Question 7: When is a SAMA used in asthma?
Answer: with a SABA during exacerbations
Question 8: When is a LAMA used in asthma?
Answer: add-on to ICS/LABA
Question 9: Which drug should always be used in combination with ICS (not monotherapy)?
Answer: LABA
Question 10: When is omalizumab used?
Answer: severe allergic asthma
Question 11: What are the options for severe eosinophilic asthma?
Answer: mepolizumab, reslizumab, benralizumab, dupilumab
Page 1
, Question 12: mepolizumab, reslizumab, benralizumab MOA
Answer: IL-5 inhibitors
Question 13: dupilumab MOA
Answer: IL-3 and 4 inhibitor
Question 14: Asthma Step 1
Answer: symptoms <2x/month; prn ICS/formoterol or SABA + ICS
Question 15: Asthma Step 2
Answer: symptoms e2x/month; prn ICS/formoterol or prn SABA + daily ICS
Question 16: Asthma Step 3
Answer: symptoms most days or waking at least 1 night per week; daily ICS/formoterol or ICS/LABA
Question 17: Asthma Step 4
Answer: daily symptoms, waking at least 1 night per week; daily medium dose ICS/formoterol or medium
ICS/LABA
Question 18: Asthma Step 5
Answer: severe; daily high dose ICS/formoterol or ICS/LABA
Question 19: How should asthma control be assessed?
Answer: Questions: Daytime sx >2x/wk? Nighttime awakenings? SABA >2x/wk? Limited activity? 0 =
well controlled; 1-2 = partly controlled, step up 1; 3-4 = uncontrolled, step up 1-2
Question 20: beta-2 agonist asthma MOA
Answer: cause bronchial smooth muscle relaxation and dilation
Question 21: montelukast MOA
Answer: leukotriene D4 inhibitor
Question 22: zafirlukast MOA
Answer: LTD4 and LTE4 receptor antagonist
Page 2
Question 1: Asthma is characterized by -
Answer: chronic airway inflammation and bronchoconstriction; reversible expiratory airflow limitation
Question 2: How is asthma diagnosed?
Answer: FEV1 increases by >12% post-bronchodilator
Question 3: What vaccines are recommended in asthma?
Answer: annual flu; pneumococcal
Question 4: When should allergy testing be done in asthma?
Answer: persistent symptoms and allergen association
Question 5: What is the preferred reliever in asthma?
Answer: ICS/formoterol or SABA + ICS
Question 6: formoterol MOA
Answer: LABA with fast onset
Question 7: When is a SAMA used in asthma?
Answer: with a SABA during exacerbations
Question 8: When is a LAMA used in asthma?
Answer: add-on to ICS/LABA
Question 9: Which drug should always be used in combination with ICS (not monotherapy)?
Answer: LABA
Question 10: When is omalizumab used?
Answer: severe allergic asthma
Question 11: What are the options for severe eosinophilic asthma?
Answer: mepolizumab, reslizumab, benralizumab, dupilumab
Page 1
, Question 12: mepolizumab, reslizumab, benralizumab MOA
Answer: IL-5 inhibitors
Question 13: dupilumab MOA
Answer: IL-3 and 4 inhibitor
Question 14: Asthma Step 1
Answer: symptoms <2x/month; prn ICS/formoterol or SABA + ICS
Question 15: Asthma Step 2
Answer: symptoms e2x/month; prn ICS/formoterol or prn SABA + daily ICS
Question 16: Asthma Step 3
Answer: symptoms most days or waking at least 1 night per week; daily ICS/formoterol or ICS/LABA
Question 17: Asthma Step 4
Answer: daily symptoms, waking at least 1 night per week; daily medium dose ICS/formoterol or medium
ICS/LABA
Question 18: Asthma Step 5
Answer: severe; daily high dose ICS/formoterol or ICS/LABA
Question 19: How should asthma control be assessed?
Answer: Questions: Daytime sx >2x/wk? Nighttime awakenings? SABA >2x/wk? Limited activity? 0 =
well controlled; 1-2 = partly controlled, step up 1; 3-4 = uncontrolled, step up 1-2
Question 20: beta-2 agonist asthma MOA
Answer: cause bronchial smooth muscle relaxation and dilation
Question 21: montelukast MOA
Answer: leukotriene D4 inhibitor
Question 22: zafirlukast MOA
Answer: LTD4 and LTE4 receptor antagonist
Page 2
