NSG 6005 WEEK 5 ADVANCED
PHARMACOTHERAPEUTICS (VERIFIED
AND CORRECT Q & A) SATISFACTION
GUARANTEED 2026/2027
1. In the management of chronic asthma, what is the primary mechanism by which inhaled
corticosteroids (ICS) exert their therapeutic effect?
A. Direct relaxation of airway smooth muscle
B. Inhibition of the production of inflammatory cytokines and reduction of mucosal edema
C. Antagonism of muscarinic M3 receptors in the bronchioles
D. Inhibition of the enzyme phosphodiesterase to increase cAMP levels
Answer: B
Conceptual Explanation: Inhaled corticosteroids work by suppressing the inflammatory
response, reducing the production of cytokines, and decreasing airway
hyperresponsiveness and mucosal edema.
2. A patient is prescribed Albuterol for exercise-induced bronchospasm. Which of the
following side effects should the nurse practitioner caution the patient about?
A. Bradycardia and hypotension
B. Hypoglycemia and urinary retention
,C. Sedation and increased appetite
D. Tachycardia, tremors, and hypokalemia
Answer: D
Conceptual Explanation: Albuterol is a short-acting beta-2 agonist (SABA) which can
cause sympathomimetic effects such as tachycardia and tremors, and potentially
hypokalemia due to cellular uptake of potassium.
3. Which statement regarding the Black Box Warning for Long-Acting Beta-2 Agonists (LABA)
in asthma is correct?
A. LABAs are contraindicated in patients with COPD.
B. LABAs increase the risk of asthma-related deaths when used as monotherapy.
C. LABAs should never be used in combination with inhaled corticosteroids.
D. LABAs are the first-line treatment for acute bronchospasm.
Answer: B
Conceptual Explanation: The FDA issued a black box warning stating that LABAs increase
the risk of asthma-related death when used alone; they must always be used in
combination with an ICS for asthma.
4. Montelukast (Singulair) carries a specific FDA boxed warning regarding which of the
following?
A. Acute liver failure
, B. Rhabdomyolysis when combined with statins
C. Irreversible pulmonary fibrosis
D. Severe neuropsychiatric events, including suicidal ideation
Answer: D
Conceptual Explanation: The FDA strengthened the boxed warning for Montelukast in
2020 due to the risk of serious neuropsychiatric events like agitation, aggression, and
suicidal thoughts.
5. What is the therapeutic range for serum theophylline levels in most adults?
A. 2-5 mcg/mL
B. 10-20 mcg/mL
C. 25-40 mcg/mL
D. 50-100 mcg/mL
Answer: B
Conceptual Explanation: The traditional therapeutic range for theophylline is 10-20
mcg/mL, though many patients respond well at 5-15 mcg/mL to minimize toxicity.
6. A 65-year-old male with COPD is started on Tiotropium (Spiriva). What is the mechanism of
action for this medication?
A. Long-acting muscarinic antagonist (LAMA) that blocks M3 receptors
B. Phosphodiesterase-4 inhibitor that reduces lung inflammation
PHARMACOTHERAPEUTICS (VERIFIED
AND CORRECT Q & A) SATISFACTION
GUARANTEED 2026/2027
1. In the management of chronic asthma, what is the primary mechanism by which inhaled
corticosteroids (ICS) exert their therapeutic effect?
A. Direct relaxation of airway smooth muscle
B. Inhibition of the production of inflammatory cytokines and reduction of mucosal edema
C. Antagonism of muscarinic M3 receptors in the bronchioles
D. Inhibition of the enzyme phosphodiesterase to increase cAMP levels
Answer: B
Conceptual Explanation: Inhaled corticosteroids work by suppressing the inflammatory
response, reducing the production of cytokines, and decreasing airway
hyperresponsiveness and mucosal edema.
2. A patient is prescribed Albuterol for exercise-induced bronchospasm. Which of the
following side effects should the nurse practitioner caution the patient about?
A. Bradycardia and hypotension
B. Hypoglycemia and urinary retention
,C. Sedation and increased appetite
D. Tachycardia, tremors, and hypokalemia
Answer: D
Conceptual Explanation: Albuterol is a short-acting beta-2 agonist (SABA) which can
cause sympathomimetic effects such as tachycardia and tremors, and potentially
hypokalemia due to cellular uptake of potassium.
3. Which statement regarding the Black Box Warning for Long-Acting Beta-2 Agonists (LABA)
in asthma is correct?
A. LABAs are contraindicated in patients with COPD.
B. LABAs increase the risk of asthma-related deaths when used as monotherapy.
C. LABAs should never be used in combination with inhaled corticosteroids.
D. LABAs are the first-line treatment for acute bronchospasm.
Answer: B
Conceptual Explanation: The FDA issued a black box warning stating that LABAs increase
the risk of asthma-related death when used alone; they must always be used in
combination with an ICS for asthma.
4. Montelukast (Singulair) carries a specific FDA boxed warning regarding which of the
following?
A. Acute liver failure
, B. Rhabdomyolysis when combined with statins
C. Irreversible pulmonary fibrosis
D. Severe neuropsychiatric events, including suicidal ideation
Answer: D
Conceptual Explanation: The FDA strengthened the boxed warning for Montelukast in
2020 due to the risk of serious neuropsychiatric events like agitation, aggression, and
suicidal thoughts.
5. What is the therapeutic range for serum theophylline levels in most adults?
A. 2-5 mcg/mL
B. 10-20 mcg/mL
C. 25-40 mcg/mL
D. 50-100 mcg/mL
Answer: B
Conceptual Explanation: The traditional therapeutic range for theophylline is 10-20
mcg/mL, though many patients respond well at 5-15 mcg/mL to minimize toxicity.
6. A 65-year-old male with COPD is started on Tiotropium (Spiriva). What is the mechanism of
action for this medication?
A. Long-acting muscarinic antagonist (LAMA) that blocks M3 receptors
B. Phosphodiesterase-4 inhibitor that reduces lung inflammation
