NURS 5334 ADVANCED
PHARMACOLOGY COMPREHENSIVE
EXAM QUESTIONS WITH CORRECT
ANSWERS (LATEST ), (A+
GUARANTEE).
1. A patient is prescribed a drug that is a known CYP3A4 inducer. How will this affect the
metabolism of a co-administered substrate drug metabolized by the same enzyme?
A. The serum concentration of the substrate drug will increase.
B. The half-life of the substrate drug will be prolonged.
C. The serum concentration of the substrate drug will decrease.
D. The volume of distribution of the substrate drug will decrease.
Answer: C
Conceptual Explanation: Inducers increase the synthesis of metabolic enzymes, leading to
faster metabolism and lower plasma concentrations of substrate drugs.
2. When prescribing an ACE inhibitor to a patient with chronic kidney disease, what is the
primary electrolyte abnormality that must be monitored?
A. Hypokalemia
B. Hyperkalemia
,C. Hyponatremia
D. Hypercalcemia
Answer: B
Conceptual Explanation: ACE inhibitors block aldosterone secretion, which can lead to
potassium retention, especially in patients with impaired renal function.
3. Which mechanism explains why Nitroglycerin is administered sublingually rather than
orally for acute angina?
A. To increase the rate of renal excretion
B. To avoid the hepatic first-pass effect
C. To ensure binding to alpha-1 receptors in the heart
D. To decrease the drug’s lipid solubility
Answer: B
Conceptual Explanation: Nitroglycerin has a high first-pass metabolism; sublingual
administration allows direct absorption into the systemic circulation.
4. A patient taking Warfarin is started on Amiodarone. What adjustment is typically required
for the Warfarin dose?
A. Increase the Warfarin dose
B. Switch to Heparin immediately
C. Decrease the Warfarin dose
, D. No change is needed as there is no interaction
Answer: C
Conceptual Explanation: Amiodarone inhibits CYP2C9, the primary enzyme for S-
warfarin metabolism, necessitating a dose reduction of Warfarin to prevent bleeding.
5. Which pharmacological property determines the maximum effect a drug can produce,
regardless of dose?
A. Potency
B. Efficacy
C. Therapeutic Index
D. Affinity
Answer: B
Conceptual Explanation: Efficacy refers to the maximal response (Emax) that can be
produced by a drug.
6. A patient with a history of asthma is diagnosed with hypertension. Which antihypertensive
class should be avoided if possible?
A. Calcium Channel Blockers
B. Angiotensin II Receptor Blockers
C. Thiazide Diuretics
D. Non-selective Beta-blockers
PHARMACOLOGY COMPREHENSIVE
EXAM QUESTIONS WITH CORRECT
ANSWERS (LATEST ), (A+
GUARANTEE).
1. A patient is prescribed a drug that is a known CYP3A4 inducer. How will this affect the
metabolism of a co-administered substrate drug metabolized by the same enzyme?
A. The serum concentration of the substrate drug will increase.
B. The half-life of the substrate drug will be prolonged.
C. The serum concentration of the substrate drug will decrease.
D. The volume of distribution of the substrate drug will decrease.
Answer: C
Conceptual Explanation: Inducers increase the synthesis of metabolic enzymes, leading to
faster metabolism and lower plasma concentrations of substrate drugs.
2. When prescribing an ACE inhibitor to a patient with chronic kidney disease, what is the
primary electrolyte abnormality that must be monitored?
A. Hypokalemia
B. Hyperkalemia
,C. Hyponatremia
D. Hypercalcemia
Answer: B
Conceptual Explanation: ACE inhibitors block aldosterone secretion, which can lead to
potassium retention, especially in patients with impaired renal function.
3. Which mechanism explains why Nitroglycerin is administered sublingually rather than
orally for acute angina?
A. To increase the rate of renal excretion
B. To avoid the hepatic first-pass effect
C. To ensure binding to alpha-1 receptors in the heart
D. To decrease the drug’s lipid solubility
Answer: B
Conceptual Explanation: Nitroglycerin has a high first-pass metabolism; sublingual
administration allows direct absorption into the systemic circulation.
4. A patient taking Warfarin is started on Amiodarone. What adjustment is typically required
for the Warfarin dose?
A. Increase the Warfarin dose
B. Switch to Heparin immediately
C. Decrease the Warfarin dose
, D. No change is needed as there is no interaction
Answer: C
Conceptual Explanation: Amiodarone inhibits CYP2C9, the primary enzyme for S-
warfarin metabolism, necessitating a dose reduction of Warfarin to prevent bleeding.
5. Which pharmacological property determines the maximum effect a drug can produce,
regardless of dose?
A. Potency
B. Efficacy
C. Therapeutic Index
D. Affinity
Answer: B
Conceptual Explanation: Efficacy refers to the maximal response (Emax) that can be
produced by a drug.
6. A patient with a history of asthma is diagnosed with hypertension. Which antihypertensive
class should be avoided if possible?
A. Calcium Channel Blockers
B. Angiotensin II Receptor Blockers
C. Thiazide Diuretics
D. Non-selective Beta-blockers
