NURS 5334 ADVANCED
PHARMACOLOGY FINAL EXAM V1
QUESTIONS WITH CORRECT ANSWERS
(LATEST ), (A+ GUARANTEE).
1. A patient is prescribed Rifampin for the treatment of tuberculosis. Which counseling point
is most essential regarding the side effects of this medication?
A. It can turn bodily secretions such as urine and tears orange.
B. It may cause a permanent blue-grey skin discoloration.
C. It is likely to cause severe constipation.
D. It requires frequent monitoring of serum potassium levels.
Answer: A
Conceptual Explanation: Rifampin is known to cause a harmless reddish-orange
discoloration of urine, sweat, saliva, and tears, which can also stain contact lenses.
2. A 65-year-old male with a history of heart failure and chronic obstructive pulmonary
disease (COPD) requires a beta-blocker. Which agent is the most appropriate choice?
A. Propranolol
,B. Metoprolol Succinate
C. Nadolol
D. Timolol
Answer: B
Conceptual Explanation: Metoprolol is a cardioselective beta-1 blocker, making it safer
for patients with respiratory conditions like COPD compared to non-selective blockers like
Propranolol.
3. Which mechanism explains the action of Sacubitril in the combination drug Entresto
(Sacubitril/Valsartan)?
A. Direct inhibition of renin release.
B. Antagonism of the AT1 receptor.
C. Blockade of aldosterone receptors in the distal tubule.
D. Inhibition of neprilysin, increasing natriuretic peptides.
Answer: D
Conceptual Explanation: Sacubitril is a neprilysin inhibitor, which prevents the
breakdown of endogenous natriuretic peptides, leading to vasodilation and natriuresis.
4. When prescribing an ACE inhibitor to a patient with diabetes, what is the primary renal
benefit?
A. Increased glomerular filtration rate (GFR).
, B. Reduction of intraglomerular pressure and proteinuria.
C. Promotion of potassium excretion.
D. Prevention of uric acid stone formation.
Answer: B
Conceptual Explanation: ACE inhibitors dilate the efferent arteriole, reducing
intraglomerular pressure, which helps preserve renal function and reduce albuminuria in
diabetic patients.
5. A patient taking Warfarin is started on Amiodarone for atrial fibrillation. What adjustment
should the provider anticipate?
A. Increasing the Warfarin dose by 50%.
B. Discontinuing Amiodarone due to fatal interactions.
C. Decreasing the Warfarin dose by 25-50%.
D. Replacing Warfarin with Aspirin immediately.
Answer: C
Conceptual Explanation: Amiodarone inhibits CYP2C9, the enzyme responsible for
metabolizing the more potent S-isomer of Warfarin, leading to increased INR and bleeding
risk.
6. Which of the following describes the ‘First-Pass Effect’ in pharmacology?
A. The rapid excretion of drugs via the kidneys.
PHARMACOLOGY FINAL EXAM V1
QUESTIONS WITH CORRECT ANSWERS
(LATEST ), (A+ GUARANTEE).
1. A patient is prescribed Rifampin for the treatment of tuberculosis. Which counseling point
is most essential regarding the side effects of this medication?
A. It can turn bodily secretions such as urine and tears orange.
B. It may cause a permanent blue-grey skin discoloration.
C. It is likely to cause severe constipation.
D. It requires frequent monitoring of serum potassium levels.
Answer: A
Conceptual Explanation: Rifampin is known to cause a harmless reddish-orange
discoloration of urine, sweat, saliva, and tears, which can also stain contact lenses.
2. A 65-year-old male with a history of heart failure and chronic obstructive pulmonary
disease (COPD) requires a beta-blocker. Which agent is the most appropriate choice?
A. Propranolol
,B. Metoprolol Succinate
C. Nadolol
D. Timolol
Answer: B
Conceptual Explanation: Metoprolol is a cardioselective beta-1 blocker, making it safer
for patients with respiratory conditions like COPD compared to non-selective blockers like
Propranolol.
3. Which mechanism explains the action of Sacubitril in the combination drug Entresto
(Sacubitril/Valsartan)?
A. Direct inhibition of renin release.
B. Antagonism of the AT1 receptor.
C. Blockade of aldosterone receptors in the distal tubule.
D. Inhibition of neprilysin, increasing natriuretic peptides.
Answer: D
Conceptual Explanation: Sacubitril is a neprilysin inhibitor, which prevents the
breakdown of endogenous natriuretic peptides, leading to vasodilation and natriuresis.
4. When prescribing an ACE inhibitor to a patient with diabetes, what is the primary renal
benefit?
A. Increased glomerular filtration rate (GFR).
, B. Reduction of intraglomerular pressure and proteinuria.
C. Promotion of potassium excretion.
D. Prevention of uric acid stone formation.
Answer: B
Conceptual Explanation: ACE inhibitors dilate the efferent arteriole, reducing
intraglomerular pressure, which helps preserve renal function and reduce albuminuria in
diabetic patients.
5. A patient taking Warfarin is started on Amiodarone for atrial fibrillation. What adjustment
should the provider anticipate?
A. Increasing the Warfarin dose by 50%.
B. Discontinuing Amiodarone due to fatal interactions.
C. Decreasing the Warfarin dose by 25-50%.
D. Replacing Warfarin with Aspirin immediately.
Answer: C
Conceptual Explanation: Amiodarone inhibits CYP2C9, the enzyme responsible for
metabolizing the more potent S-isomer of Warfarin, leading to increased INR and bleeding
risk.
6. Which of the following describes the ‘First-Pass Effect’ in pharmacology?
A. The rapid excretion of drugs via the kidneys.
