NSG 552 Psychopharmacology, covering material
from Exams 1, 2, and 3 at Wilkes University.
100
QUESTIONS
TABLE OF CONTENTS
# TOPIC
NSG 552 Psychopharmacology, covering material from Exams 1, 2, and 3 at
1
Wilkes University.
Page 1
,Q1
A nurse practitioner explains to a patient that "what the body does to the drug"
is known as:
A) Pharmacodynamics
B) Pharmacokinetics CORRECT
C) Pharmacotherapeutics
D) Pharmacogenomics
Rationale
Pharmacokinetics describes the processes of absorption, distribution, metabolism,
and excretion (ADME)—what the body does to the drug. Pharmacodynamics is what
the drug does to the body.
Q2
What is the definition of pharmacodynamics?
A) The study of drug metabolism in the liver
B) The study of drug excretion by the kidneys
C) The study of what drugs do to the body at target sites CORRECT
D) The study of drug absorption in the GI tract
Rationale
Pharmacodynamics describes drug actions at receptors, ion channels, enzymes, and
carrier proteins/reuptake pumps.
Page 2
,Q3
Which phase of pharmacokinetics involves the conversion of a drug into
metabolites, primarily in the liver?
A) Absorption
B) Distribution
C) Metabolism CORRECT
D) Excretion
Rationale
Metabolism (biotransformation) occurs mainly in the liver via cytochrome P450
enzymes, converting drugs into more water-soluble metabolites for excretion.
Q4
The cytochrome P450 enzyme system is primarily responsible for which
pharmacokinetic process?
A) Drug absorption
B) Drug distribution
C) Drug metabolism CORRECT
D) Drug excretion
Rationale
The CYP450 system in the liver is the major site of drug metabolism. Inhibition or
induction of these enzymes causes clinically significant drug-drug interactions.
Page 3
, Q5
A drug with high protein binding will have which characteristic?
A) Rapid onset of action
B) Reduced free (active) drug available CORRECT
C) Increased renal excretion
D) Decreased half-life
Rationale
Highly protein-bound drugs remain bound to albumin and are inactive. Only the
unbound (free) fraction is pharmacologically active and available for
metabolism/excretion.
Q6
Which term describes the concentration of a drug required to produce 50% of
the maximum response?
A) Affinity
B) Efficacy
C) Potency (EC50) CORRECT
D) Bioavailability
Rationale
EC50 is the concentration producing 50% of maximal effect, a measure of drug
potency. Lower EC50 = higher potency.
Page 4
from Exams 1, 2, and 3 at Wilkes University.
100
QUESTIONS
TABLE OF CONTENTS
# TOPIC
NSG 552 Psychopharmacology, covering material from Exams 1, 2, and 3 at
1
Wilkes University.
Page 1
,Q1
A nurse practitioner explains to a patient that "what the body does to the drug"
is known as:
A) Pharmacodynamics
B) Pharmacokinetics CORRECT
C) Pharmacotherapeutics
D) Pharmacogenomics
Rationale
Pharmacokinetics describes the processes of absorption, distribution, metabolism,
and excretion (ADME)—what the body does to the drug. Pharmacodynamics is what
the drug does to the body.
Q2
What is the definition of pharmacodynamics?
A) The study of drug metabolism in the liver
B) The study of drug excretion by the kidneys
C) The study of what drugs do to the body at target sites CORRECT
D) The study of drug absorption in the GI tract
Rationale
Pharmacodynamics describes drug actions at receptors, ion channels, enzymes, and
carrier proteins/reuptake pumps.
Page 2
,Q3
Which phase of pharmacokinetics involves the conversion of a drug into
metabolites, primarily in the liver?
A) Absorption
B) Distribution
C) Metabolism CORRECT
D) Excretion
Rationale
Metabolism (biotransformation) occurs mainly in the liver via cytochrome P450
enzymes, converting drugs into more water-soluble metabolites for excretion.
Q4
The cytochrome P450 enzyme system is primarily responsible for which
pharmacokinetic process?
A) Drug absorption
B) Drug distribution
C) Drug metabolism CORRECT
D) Drug excretion
Rationale
The CYP450 system in the liver is the major site of drug metabolism. Inhibition or
induction of these enzymes causes clinically significant drug-drug interactions.
Page 3
, Q5
A drug with high protein binding will have which characteristic?
A) Rapid onset of action
B) Reduced free (active) drug available CORRECT
C) Increased renal excretion
D) Decreased half-life
Rationale
Highly protein-bound drugs remain bound to albumin and are inactive. Only the
unbound (free) fraction is pharmacologically active and available for
metabolism/excretion.
Q6
Which term describes the concentration of a drug required to produce 50% of
the maximum response?
A) Affinity
B) Efficacy
C) Potency (EC50) CORRECT
D) Bioavailability
Rationale
EC50 is the concentration producing 50% of maximal effect, a measure of drug
potency. Lower EC50 = higher potency.
Page 4
