PL.a-t - Polymers and life | PL1-9 |
PL.Q Exam questions from past papers
State the meaning of the symbols used in the mechanism and explain ● E is enzyme, S is substrate, ES is enzyme-substrate complex,
how this mechanism accounts for the shape of the curve in fig 35.2? EP is enzyme-product complex, P is product
Low [S]
● When [S] is low there are enough active sites for E to bind to all
of S -> rate increases as [S] increases
● Rate is proportional to [S]
● Reaction is 1st Order w.r.t [S]
● RDS is E+S->ES
High [S]
● When [S] is high all active sites are occupied -> no change in
rate
● Increasing [S] has no effect on rate
● Reaction is zero order w.r.t [S]
● RDS is EP -> E+P (or ES->EP)
Draw a ring around the pharmacophore on the structure of ‘Imatinib’
ALLOW lines cutting bonds to do so anywhere on the bond.
above?
Suggest how this pharmacophore (Compound A) interferes with the It has a complementary shape to the enzyme (1) so fits into the active
function of the enzyme? [3] site (1) blocking the substrate from entering. (1)
, Explain how specific pairing suggests a copying mechanism for the ● Hydrogen bonds break between base pairs [1]
replication of DNA? [3] ● Two single strands are formed (helices) [1]
● Each base forms hydrogen bonds to a new complementary
base [1]
From F334 paper old spec so your choice whether you want to learn
for new spec or not
What is the reason that CO and N2 can be distinguished by high- ● C as high resolution mass spec is to 4 decimal places
resolution mass spectrometry?
● As the mass spec can see the Mr to 4d.p
● Different compounds have different Mr values in the decimal
places
The Mr of C6H14O is 102. Explain how high-resolution mass
● Atoms of the element have Ar value that are not exact whole
spectroscopy can be used to distinguish between this compound and
numbers
others with the same Mr but difference molecular formula? (3)
Give 1 advantage and disadvantage of using enzymes in industrial
processes?
Advantages
● Allow faster reaction at lower temperatures
● Saves fuel
Disadvantages
● Easily denatured
● Inhibited
● Sensitive to pH
● Difficult to recover after use
● Straight line at rate = 0
● Active site is destroyed so changes shape
Describe the appearance of the graph of rate against [S] at 70
degrees?
PL.a-e - Structure & Bonding | PL4 | PL5 | PL7 | PL8 |
What are amino acids? And draw general structure A central carbon with an amine and a carboxyl group
PL.Q Exam questions from past papers
State the meaning of the symbols used in the mechanism and explain ● E is enzyme, S is substrate, ES is enzyme-substrate complex,
how this mechanism accounts for the shape of the curve in fig 35.2? EP is enzyme-product complex, P is product
Low [S]
● When [S] is low there are enough active sites for E to bind to all
of S -> rate increases as [S] increases
● Rate is proportional to [S]
● Reaction is 1st Order w.r.t [S]
● RDS is E+S->ES
High [S]
● When [S] is high all active sites are occupied -> no change in
rate
● Increasing [S] has no effect on rate
● Reaction is zero order w.r.t [S]
● RDS is EP -> E+P (or ES->EP)
Draw a ring around the pharmacophore on the structure of ‘Imatinib’
ALLOW lines cutting bonds to do so anywhere on the bond.
above?
Suggest how this pharmacophore (Compound A) interferes with the It has a complementary shape to the enzyme (1) so fits into the active
function of the enzyme? [3] site (1) blocking the substrate from entering. (1)
, Explain how specific pairing suggests a copying mechanism for the ● Hydrogen bonds break between base pairs [1]
replication of DNA? [3] ● Two single strands are formed (helices) [1]
● Each base forms hydrogen bonds to a new complementary
base [1]
From F334 paper old spec so your choice whether you want to learn
for new spec or not
What is the reason that CO and N2 can be distinguished by high- ● C as high resolution mass spec is to 4 decimal places
resolution mass spectrometry?
● As the mass spec can see the Mr to 4d.p
● Different compounds have different Mr values in the decimal
places
The Mr of C6H14O is 102. Explain how high-resolution mass
● Atoms of the element have Ar value that are not exact whole
spectroscopy can be used to distinguish between this compound and
numbers
others with the same Mr but difference molecular formula? (3)
Give 1 advantage and disadvantage of using enzymes in industrial
processes?
Advantages
● Allow faster reaction at lower temperatures
● Saves fuel
Disadvantages
● Easily denatured
● Inhibited
● Sensitive to pH
● Difficult to recover after use
● Straight line at rate = 0
● Active site is destroyed so changes shape
Describe the appearance of the graph of rate against [S] at 70
degrees?
PL.a-e - Structure & Bonding | PL4 | PL5 | PL7 | PL8 |
What are amino acids? And draw general structure A central carbon with an amine and a carboxyl group
