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NBME CBSE Actual Test Questions &
Answers (USMLE Step 1) 2025–2026 |
Comprehensive Quiz Bank with 100%
Correct Answers | Verified Medical Exam
Study Guide
Prepare confidently for your NBME Comprehensive Basic Science Exam
(CBSE) and USMLE Step 1 with this verified 2025–2026 quiz bank.
This trusted study pack features actual NBME-style questions with 100%
correct answers and detailed medical explanations covering every organ
system and discipline tested on Step 1.
✅ What’s Included:
• NBME CBSE Actual Test Questions & Answers (2025–2026 Versions)
• Verified Quiz Bank with 100% Correct Answers
• In-Depth Explanations for All USMLE Step 1 Topics
• Covers Physiology, Biochemistry, Pathology, Pharmacology, Microbiology, Behavioral Science &
Anatomy
• Printable & User-Friendly PDF Format
• Rated ★★★★★ by Medical Students Worldwide
Whether you’re preparing for Step 1, CBSE practice exams, or medical school comprehensive
testing, this guide ensures mastery of high-yield Step 1 concepts, helping you boost recall,
confidence, and score performance.
ct
and 3/15/2026,
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NBME CBSE ACTUAL TEST
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected beneficial effect of
the drug is due to which of the following?
Decreased Osteoclast Activity
Cohot Study of elderly women – relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion about
the effect of exercise on the risk of hip fracture?
Statistically Significant Overall Increase Risk
00:03
00:49
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is 80/min
and blood pressure is 130/70. The most immediate treatment mechanism of action?
Increased nitric oxide concentration
24 year old woman – spilled hot grease on her left leg while working at a fast-food restaurant. Exam of
leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was most likely
caused by increased activity of which?
a. Vascular Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels – early wound repair
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull fracture – increased
serum osm and decreased urin osm. Following desmopressin urine osm increases. Desmopressin’s
effect is due to the activation of which of the following?
ct
and 3/15/2026,
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a. Adenylyl Cyclase
Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy – 4 day history of fever and cough. He attends day care center. Chest exam shows
intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The infectious
agent most likely has which of the following properties?
Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light headedness but no difficulty
swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this patient?
B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week of fatigue.
He recentaly had sex with one partner. Physical exam show cervical lymphadenopathy and pharyngeal
erythema with a creamy exudate. DX?
Infectious Mononucleosis
57 year old man – radiation therapy for squamous cell carcinoma of the lung. Despite therapy, tumor
increases in size and he dies 6 months later. The progressive tumor growth is due to a defect in cell
cycle arrest in which of the following phases of cell cycle?
G1
28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 – imaging shows
bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered granulomas.
DX?
Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two gene
deletion. If the two gene is trans – what percentage of offspring will have a two gene deletion?
50%
ct
and 3/15/2026,
answers
answers
Nbmeusmle
quiz1:30:50
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previously healthy 40 year brought to emergency department by her husband – 2 day history of fever,
lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower extremities – 3+
polychromasia and 3+ schistocytes and Low platelets Dx?
Thrombotic Thrombocytopenia Purpura
00:03
00:49
16 year old boy – is admitted to the ER because of a knife wound to the left side of his chest. An X-ray
of the chest shows an air-fluid level in the left side of the chest, partial collapse of the left lung, and
the elevation of the stomach bubble. The mediastinum is midline. DX?
Hemopneumpothorax under tension
49 year old woman – coronary artery disease – BP 140/90 - High Cholesterol, High LDL (190), High
triglycerides (350) – TX with atorvastatin and losartan. What are the effects on HDL and Triglycerides?
HDL increased
Triglycerides Decreased
73 yeare old – diffuse weakness and tingling of her arms and legs. Sensation and vibration and
position is decreased in all extremities. What vitamin deficiency?
Vitamin B12 – (cyanocobalamin)
Tea and Toast – low B12 in diet
15 year old girl – 3 month history of acne – which is the underlying cause of the patients acne?
Stimulation of Sebaceous Glands by androgens
ct
and 3/15/2026,
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answers
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1 medical examination.docx
NBME CBSE Actual Test Questions &
Answers (USMLE Step 1) 2025–2026 |
Comprehensive Quiz Bank with 100%
Correct Answers | Verified Medical Exam
Study Guide
Prepare confidently for your NBME Comprehensive Basic Science Exam
(CBSE) and USMLE Step 1 with this verified 2025–2026 quiz bank.
This trusted study pack features actual NBME-style questions with 100%
correct answers and detailed medical explanations covering every organ
system and discipline tested on Step 1.
✅ What’s Included:
• NBME CBSE Actual Test Questions & Answers (2025–2026 Versions)
• Verified Quiz Bank with 100% Correct Answers
• In-Depth Explanations for All USMLE Step 1 Topics
• Covers Physiology, Biochemistry, Pathology, Pharmacology, Microbiology, Behavioral Science &
Anatomy
• Printable & User-Friendly PDF Format
• Rated ★★★★★ by Medical Students Worldwide
Whether you’re preparing for Step 1, CBSE practice exams, or medical school comprehensive
testing, this guide ensures mastery of high-yield Step 1 concepts, helping you boost recall,
confidence, and score performance.
ct
and 3/15/2026,
answers
answers
Nbmeusmle
quiz1:30:50
cbse Nbme
step
bank 1PM
actual cbse
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1 medical examination.docx
NBME CBSE ACTUAL TEST
62 year old woman - osteoporosis – a bisphosphonate is prescribed. The expected beneficial effect of
the drug is due to which of the following?
Decreased Osteoclast Activity
Cohot Study of elderly women – relative risk ratio for hip fractures among those who exercise
regularly is 1.2 (95% confidence interval of 1.1 to 1.8). Which of the following is the conclusion about
the effect of exercise on the risk of hip fracture?
Statistically Significant Overall Increase Risk
00:03
00:49
52 year old man goes to ER with chest pain radiating to his jaw while shoveling snow. Pulse is 80/min
and blood pressure is 130/70. The most immediate treatment mechanism of action?
Increased nitric oxide concentration
24 year old woman – spilled hot grease on her left leg while working at a fast-food restaurant. Exam of
leg shows 7cm pink, soft, granular, edematous wound. The formation of this tissue was most likely
caused by increased activity of which?
a. Vascular Endothelial Growth Factor
VEGF – stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels – early wound repair
27 year old man- MVC – skull x-ray shows a linear, nondepressed basal skull fracture – increased
serum osm and decreased urin osm. Following desmopressin urine osm increases. Desmopressin’s
effect is due to the activation of which of the following?
ct
and 3/15/2026,
answers
answers
Nbmeusmle
quiz1:30:50
cbse Nbme
step
bank 1PM
actual cbse
with actual
medical
test
all Nbme
test
questions
the cbse
questions
actualand
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quizquiz
andbank
answers
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step 1 medical
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1 medical examination.docx
a. Adenylyl Cyclase
Adenylate Cyclase – ATP – CAMP -- PROTEKINASE A -- Ca
v2
A 10 month old boy – 4 day history of fever and cough. He attends day care center. Chest exam shows
intercostal retractions along with bilateral, diffuse wheezes and expiratory rhonchi. The infectious
agent most likely has which of the following properties?
Mediation of Cell Entry via a fusion protein
A 17 year old girl in ED – 15 minutes after being stung by a bee. Mild light headedness but no difficulty
swallowing- Bilateral wheezing - Which is most appropriate pharmacotherapy for this patient?
B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late afternoon. 1 week of fatigue.
He recentaly had sex with one partner. Physical exam show cervical lymphadenopathy and pharyngeal
erythema with a creamy exudate. DX?
Infectious Mononucleosis
57 year old man – radiation therapy for squamous cell carcinoma of the lung. Despite therapy, tumor
increases in size and he dies 6 months later. The progressive tumor growth is due to a defect in cell
cycle arrest in which of the following phases of cell cycle?
G1
28 year old – lived in sub-Saharan Africa – until he came to the US. Temp of 100.4 – imaging shows
bilateral hydroureter and hydronephrosis. Biopsy shows marked fibrosis and scattered granulomas.
DX?
Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion and man has two gene
deletion. If the two gene is trans – what percentage of offspring will have a two gene deletion?
50%
ct
and 3/15/2026,
answers
answers
Nbmeusmle
quiz1:30:50
cbse Nbme
step
bank 1PM
actual cbse
with actual
medical
test
all Nbme
test
questions
the cbse
questions
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1 medical examination.docx
previously healthy 40 year brought to emergency department by her husband – 2 day history of fever,
lethargy, confusion. PE shows scattered petechiae and ecchymoses over the lower extremities – 3+
polychromasia and 3+ schistocytes and Low platelets Dx?
Thrombotic Thrombocytopenia Purpura
00:03
00:49
16 year old boy – is admitted to the ER because of a knife wound to the left side of his chest. An X-ray
of the chest shows an air-fluid level in the left side of the chest, partial collapse of the left lung, and
the elevation of the stomach bubble. The mediastinum is midline. DX?
Hemopneumpothorax under tension
49 year old woman – coronary artery disease – BP 140/90 - High Cholesterol, High LDL (190), High
triglycerides (350) – TX with atorvastatin and losartan. What are the effects on HDL and Triglycerides?
HDL increased
Triglycerides Decreased
73 yeare old – diffuse weakness and tingling of her arms and legs. Sensation and vibration and
position is decreased in all extremities. What vitamin deficiency?
Vitamin B12 – (cyanocobalamin)
Tea and Toast – low B12 in diet
15 year old girl – 3 month history of acne – which is the underlying cause of the patients acne?
Stimulation of Sebaceous Glands by androgens
ct
and 3/15/2026,
answers
answers
Nbmeusmle
quiz1:30:50
cbse Nbme
step
bank 1PM
actual cbse
with actual
medical
test
all Nbme
test
questions
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questions
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