NURS 5357 NEUROBIOLOGY EXAM 2
COMPREHENSIVE STUDY GUIDE
QUESTIONS AND VERIFIED ANSWERS FULL
REVIEW
●● Briefly explain the dopamine hypothesis of the positive and negative
symptoms of schizophrenia.
Answer: The dopamine hypothesis of schizophrenia consists of:
There is too much dopamine activity in the mesolimbic dopamine
pathway, which leads to positive symptoms (such as hallucinations and
delusions).
There is also too little dopamine activity in the mesocortical dopamine
pathway, which leads to negative symptoms (such as blunting of affect,
poverty of speech, anhedonia, and so on).
●● What pathway is responsible for regulating dopamine in the
hypothalamus and affects the release of prolactin?
Answer: Tuberoinfundibular pathway
●● Drug-induced Parkinson's is caused by a decrease of dopamine in
what pathway?
Answer: Nigrostriatal pathway
,●● Brodmann's areas are differentiated by the:
Answer: Cellular architecture
●● All of the following are true about the hippocampus except that it:
Answer: Is disrupted by frontal lobotomy
●● Which of the following statements is true about the cerebellum:
Answer: Has been implicated in autism.
●● Cytokines are involved with all of the following except:
Answer: identifying T. pallidum
●● Which of the following is a possible explanation for schizophrenia:
Answer: Excessive pruning
●● Possible explanations for the role of thyroid hormone in mood
disorders include all of the following except:
Answer: Changes in GR's
●● All of the following are plausible theories on the etiology of
schizophrenia except?
Answer: Dopamine hypothesis
, ●● Auditory hallucinations have been shown to activate which region on
fMRI?
Answer: Superior temporal lobe
●● All of the following suggest white matter impairment in
schizophrenia except?
Answer: Significantly reduced white matter volume
●● Evidence that GABA interneurons are impaired in schizophrenia
Answer: Reduced GAD67
●● All of the following support the reduced neuropil hypothesis except?
Answer: oligodendrocyte dysfunction
●● Evidence that schizophrenia is a biological disorder includes all of
the following except?
Answer: Gliosis in the prefrontal cortex
●● Neurodevelopmental causes that could explain schizophrenia include
excessive amounts of all of the following except:
Answer: Myelination
COMPREHENSIVE STUDY GUIDE
QUESTIONS AND VERIFIED ANSWERS FULL
REVIEW
●● Briefly explain the dopamine hypothesis of the positive and negative
symptoms of schizophrenia.
Answer: The dopamine hypothesis of schizophrenia consists of:
There is too much dopamine activity in the mesolimbic dopamine
pathway, which leads to positive symptoms (such as hallucinations and
delusions).
There is also too little dopamine activity in the mesocortical dopamine
pathway, which leads to negative symptoms (such as blunting of affect,
poverty of speech, anhedonia, and so on).
●● What pathway is responsible for regulating dopamine in the
hypothalamus and affects the release of prolactin?
Answer: Tuberoinfundibular pathway
●● Drug-induced Parkinson's is caused by a decrease of dopamine in
what pathway?
Answer: Nigrostriatal pathway
,●● Brodmann's areas are differentiated by the:
Answer: Cellular architecture
●● All of the following are true about the hippocampus except that it:
Answer: Is disrupted by frontal lobotomy
●● Which of the following statements is true about the cerebellum:
Answer: Has been implicated in autism.
●● Cytokines are involved with all of the following except:
Answer: identifying T. pallidum
●● Which of the following is a possible explanation for schizophrenia:
Answer: Excessive pruning
●● Possible explanations for the role of thyroid hormone in mood
disorders include all of the following except:
Answer: Changes in GR's
●● All of the following are plausible theories on the etiology of
schizophrenia except?
Answer: Dopamine hypothesis
, ●● Auditory hallucinations have been shown to activate which region on
fMRI?
Answer: Superior temporal lobe
●● All of the following suggest white matter impairment in
schizophrenia except?
Answer: Significantly reduced white matter volume
●● Evidence that GABA interneurons are impaired in schizophrenia
Answer: Reduced GAD67
●● All of the following support the reduced neuropil hypothesis except?
Answer: oligodendrocyte dysfunction
●● Evidence that schizophrenia is a biological disorder includes all of
the following except?
Answer: Gliosis in the prefrontal cortex
●● Neurodevelopmental causes that could explain schizophrenia include
excessive amounts of all of the following except:
Answer: Myelination
