NURS 5334 ADVANCED PHARMACOLOGY
TEST 2 REVIEW SHEET 2026 TESTED
QUESTIONS WITH COMPLETE ANSWERS
GRADED A+
⩥ Volume of distribution.
Answer: Vd = amount of drug in the body divided by the amount of drug
in the plasma divided by bioavailability.
⩥ Bioavailability.
Answer: How much drug makes it into the system. Must account for
absorption and extraction.
⩥ Extraction.
Answer: How much of the drugs bioavailability can be used by the body.
⩥ **IV route dosing (parenteral).
Answer: Goes directly to the body. Results in 100% bioavailability.
Decreasing first pass effect, decreasing absorption limitations,
extractions...
By passes absorption and extraction.
, ⩥ Loading dose.
Answer: [Peak] concentration X Vd divided by bioavailability
⩥ Maintenance dose.
Answer: [Peak] X Clearance divided by bioavailability
⩥ Clearance is affected by.
Answer: Kidney function
⩥ **If a patient has kidney disease you would.
Answer: Decrease your maintenance dose; loading dose stays the same
(doesn't affect clearance)
⩥ Metabolism.
Answer:
⩥ Phase 1 reaction.
Answer: Oxidation, reduction, hydrolytic (CYP450 system in the liver)
Zone 3: Hepatic acinus where drugs are modified
Goal is to made polar, water soluble molecules
⩥ Phase 2 reaction.
TEST 2 REVIEW SHEET 2026 TESTED
QUESTIONS WITH COMPLETE ANSWERS
GRADED A+
⩥ Volume of distribution.
Answer: Vd = amount of drug in the body divided by the amount of drug
in the plasma divided by bioavailability.
⩥ Bioavailability.
Answer: How much drug makes it into the system. Must account for
absorption and extraction.
⩥ Extraction.
Answer: How much of the drugs bioavailability can be used by the body.
⩥ **IV route dosing (parenteral).
Answer: Goes directly to the body. Results in 100% bioavailability.
Decreasing first pass effect, decreasing absorption limitations,
extractions...
By passes absorption and extraction.
, ⩥ Loading dose.
Answer: [Peak] concentration X Vd divided by bioavailability
⩥ Maintenance dose.
Answer: [Peak] X Clearance divided by bioavailability
⩥ Clearance is affected by.
Answer: Kidney function
⩥ **If a patient has kidney disease you would.
Answer: Decrease your maintenance dose; loading dose stays the same
(doesn't affect clearance)
⩥ Metabolism.
Answer:
⩥ Phase 1 reaction.
Answer: Oxidation, reduction, hydrolytic (CYP450 system in the liver)
Zone 3: Hepatic acinus where drugs are modified
Goal is to made polar, water soluble molecules
⩥ Phase 2 reaction.
