MCBM Exam #2: Horovorka Questions
and Answers (Limited Edition) Correct
Solutions 2026-2027
What do all connective tissues have in common? - Correct
Answers ✅Vast extracellular matrix
What are the 4 main types of connective tissue? - Correct
Answers ✅Cartilage, Bone, Blood, and Connective Tissue
Proper
Is cartilage vascular or avascular? - Correct Answers
✅Avascular
What secretes the extracellular matrix in connective tissue? -
Correct Answers ✅Fibroblasts
What is the difference between dense regular and dense
irregular connective tissue? What do they form? - Correct
Answers ✅Regular: forms tendons, ligaments, and
aponeuroses. Collagen bundles are arranged in parallel
orientation, giving the tissue greater tensile strength.
Irregular: Forms the capsules of solid organs, the submucosa
of hollow organs, and the reticular layer of skin. Oriented in
different directions, allows resistance to excessive stretching.
What is the extracellular matrix composed of? - Correct
Answers ✅Ground substance and Fibers
,MCBM Exam #2: Horovorka Questions
and Answers (Limited Edition) Correct
Solutions 2026-2027
What is the purpose of ground substance? - Correct
Answers ✅Provides compressive resistance, flexibility, and
can be a biochemical barrier.
What usually makes up ground substance? - Correct
Answers ✅Water, proteoglycans/glycoproteins (proteins
with covalently attached polysaccharides), and
glycosaminoglycans (Long unbranched polysaccharides)
What is the most important glycosaminoglycan in ground
substance? What charge does it have? What is the result? -
Correct Answers ✅Hyaluronic Acid, has a negative charge
which draws in water.
What is collagen (generally)? - Correct Answers
✅Glycoprotein with sugars attached to hydroxylized amino
acids.
What amino acids are being hydrolyzed? - Correct Answers
✅Proline and Lysine
What is tropocollagen? - Correct Answers ✅A structural
component of collagen formed by 3 chains of amino acids to
form a triple helix.
, MCBM Exam #2: Horovorka Questions
and Answers (Limited Edition) Correct
Solutions 2026-2027
Tropogollagen is made up of 3 different chains of collagen.
Are the 3 chains the same? - Correct Answers ✅All three
can be the same, there may be two types, or all different
types!
What are collagen fibrils formed from? How are they
oriented? - Correct Answers ✅They are formed from
polymerized tropocollagen molecules. They are oriented head
to tail in parallel fashion.
What are collagen fibers? What kind of imaging can they be
seen by? - Correct Answers ✅They are groups of fibrils
large enough to be seen by light microscopy.
What are the different types of collagens? Where are they
found? - Correct Answers ✅Type 1: Connective Tissue
Proper and Bone
Type 2: Cartilage
Type 3: Reticular Fibers
Type 4: Basal Lamina
and Answers (Limited Edition) Correct
Solutions 2026-2027
What do all connective tissues have in common? - Correct
Answers ✅Vast extracellular matrix
What are the 4 main types of connective tissue? - Correct
Answers ✅Cartilage, Bone, Blood, and Connective Tissue
Proper
Is cartilage vascular or avascular? - Correct Answers
✅Avascular
What secretes the extracellular matrix in connective tissue? -
Correct Answers ✅Fibroblasts
What is the difference between dense regular and dense
irregular connective tissue? What do they form? - Correct
Answers ✅Regular: forms tendons, ligaments, and
aponeuroses. Collagen bundles are arranged in parallel
orientation, giving the tissue greater tensile strength.
Irregular: Forms the capsules of solid organs, the submucosa
of hollow organs, and the reticular layer of skin. Oriented in
different directions, allows resistance to excessive stretching.
What is the extracellular matrix composed of? - Correct
Answers ✅Ground substance and Fibers
,MCBM Exam #2: Horovorka Questions
and Answers (Limited Edition) Correct
Solutions 2026-2027
What is the purpose of ground substance? - Correct
Answers ✅Provides compressive resistance, flexibility, and
can be a biochemical barrier.
What usually makes up ground substance? - Correct
Answers ✅Water, proteoglycans/glycoproteins (proteins
with covalently attached polysaccharides), and
glycosaminoglycans (Long unbranched polysaccharides)
What is the most important glycosaminoglycan in ground
substance? What charge does it have? What is the result? -
Correct Answers ✅Hyaluronic Acid, has a negative charge
which draws in water.
What is collagen (generally)? - Correct Answers
✅Glycoprotein with sugars attached to hydroxylized amino
acids.
What amino acids are being hydrolyzed? - Correct Answers
✅Proline and Lysine
What is tropocollagen? - Correct Answers ✅A structural
component of collagen formed by 3 chains of amino acids to
form a triple helix.
, MCBM Exam #2: Horovorka Questions
and Answers (Limited Edition) Correct
Solutions 2026-2027
Tropogollagen is made up of 3 different chains of collagen.
Are the 3 chains the same? - Correct Answers ✅All three
can be the same, there may be two types, or all different
types!
What are collagen fibrils formed from? How are they
oriented? - Correct Answers ✅They are formed from
polymerized tropocollagen molecules. They are oriented head
to tail in parallel fashion.
What are collagen fibers? What kind of imaging can they be
seen by? - Correct Answers ✅They are groups of fibrils
large enough to be seen by light microscopy.
What are the different types of collagens? Where are they
found? - Correct Answers ✅Type 1: Connective Tissue
Proper and Bone
Type 2: Cartilage
Type 3: Reticular Fibers
Type 4: Basal Lamina
