PRITE Questions and Answers Verified Solutions Latest Update
Question: 1. Pharmacogenetic testing is recommend- Carbamazepine ed in patients of Asian and
Southeast Asian ancestry prior to initiation which of Before starting: individuals with ancestry the
following?
Answer:
a. Imipramine b. lamotrigene c. Fluvoxamine d. Valproic Acid e. Carbamazepine 2.
Question: Which of the following pathways is implicated in the development of tardive dyskinesia a.
mesolimbic b. nigrostriatal c. mesocortical d. tuberoinfundibular e. incertohypothalamic
3. Which of the following hormones is involved in osmoregulation, food intake, and female and sexual
behaviors a. oxytocin b. estrogen c. melatonin d. testosterone e. progesterone
4. Which of the following has dominant inheritance a. wilson disease across broad areas of asia should
consider screening for the presence of HLAB*1502 allele; those with the HLA-B*1502 allele should
not be treated with carbamazepine Nigrostriatal Oxytocin a. wilson disease - AR b. PKU - AR
C. Sickle Cell Disease - AR 2/61 b. PKU
C. Sickle Cell Disease d. Huntington Disease e. Cri-Du-Chat
5. Posttraumatic stress disorder has been most commonly associated with reduced volume on MRI in
which brain region a. thalamus b. hippocampus c. hypothalamus d. cerebral cortex e. corpus callosum
6. A patient with Alzheimer dx struggles to take oral acetylcholinesterase inhibitors due to severe
nausea and vomiting. Which of the following medications offers an alternative route of administration
that may improve tolerability?
Answer:
a. tacrine b. donepezil c. memantine d. rivastigmine e. galantamine
7. Evidence best supports use of acupuncture for which of the following indications a. anxiety b.
insomnia c. depression d. Huntington Disease -AD e. Cri-Du-Chat - most not inherited, random
Hippocampus Rivastigmine - Transdermal dosage available Pain management 3/61 d. pain
management e. smoking cessation 8.
Question: Which of the following brain waves is most associated with alertness in an adult waking
EEG?
Answer:
a. beta b. delta c. theta d. alpha e. gamma
9. Self report tolls adminitered prior to the session aid the initial psychiatric interview by a. promoting
standardized tx plans b. increasing the efficiency of the office visit c. minimizing the risk of a
pre-conceived diagnosis d. reducing the time needed to interview the patient e. limiting false positive
and false negative identifications 10.
,Question: Which of the following symptoms must be present to make a diagnosis of manic episode a.
grandiosity b. distractibility c. flight of ideas Beta b. increasing the eflciency of the oflce visit increased
activity of energy You have an abnormal, long-lasting elevated expression of emotion along with a
high degree of energy and activity that lasts for at least one week and is present most of the day, nearly
every day. 4/61 d. decreased need for sleep
e. increased activity or energy 11. a 44 year old patient presents with extreme fatigue and depression.
Physical examination reveals darkening of skin e. adrenocorticotropic hormone stimulation test and
mucosa. Which of hte following tests This test is helpful in determining if the adrenwould most likely
lead to the diagnosis a. Porphobilinogen b. Vanillylmandelic acid c. Thyroid Stimulating Hormone d.
5-hydroxyindoleacetic acid al and pituitary glands are normal. It is most often used when adrenal gland
disorders, such as Addison's disease or pituitary insuflciency, are suspected. Normal Values: An
increase in cortisol after stimulation by ACTH is e. adrenocorticotropic hormone stimula- normal. tion
test
12. Buprenorphine is combined with Naloxone in oral formulations to reduce which of the following a.
cravings b. side effects c. abuse potential d. drug interactions e. lethality in overdose Abuse potential
Buprenorphine + Naloxone = suboxone Buprenorphine is a partial agonist (thus can cause immediate
withdrawal in a pt currently taking opioids but can relieve withdrawal if a pt is already experiencing it)
and an antagonist at the kappa opioid receptor Naloxone is a mu receptor antagonist and can therefore
block the effects of buprenorphine but because it has poor sublingual bioavailability, it does not
interfere with buprenorphine's effects when used properly as it does 5/61
13. Childhood trauma, which increases risk for depression and PTSD has been correlated with an
increase in the expression of which of hte following genes a. AKT1
B. SERT
C. FRM1
D. ApoE2
E. FKBP5 have good parenteral bioavailability Thus if one tries to administer suboxone IV, naloxone
will prevent any rewarding effects from buprenorphine FKBP5 What does the FKBP5 gene do?
Answer:
The FKBP5 gene encodes a molecular co-chaperone of the glucocorticoid receptor complex, which
modulates intracellular glucocorticoid signaling and plays an important role in homeostatic regulation
of the stress response a. The AKT1 gene has also been implicated in schizophrenia by association
studies and decreased protein expression in the brains of schizophrenic patients. b. c. Fragile X
syndrome (FXS) is a genetic disorder. FXS is caused by changes in a gene called Fragile X Messenger
Ribonucleoprotein 1 (FMR1). FMR1 usually makes a protein called FMRP that is needed for brain
development. People who have FXS do not make this protein. d. 6/61 14.
, Question: Which of the following is the most compelling argument for allowing all clinicians to have
unrestricted access to mental health information in EHR?
Answer:
A. privacy rights do not apply to patients admitted involuntarily b. Confidentiality of EHR info is less
relevant in the era of big data c. unrestricted access to psychiatric records lowers the stigma of mental
illness d. social media acceptance has diminished the concern for privacy and confidentiality e.
Readmission rates tend to be lower in hospitals with unrestricted access to the EHR 15. 65 YO W
PROGRESSIVE COGNITIVE DE CLINE. Lumbar puncture shows ordinary opening pressure and is
otherwise nore. Readmission rates tend to be lower in hospitals with unrestricted access to the EHR
A. gait apraxia Gait apraxia is most commonly a part of the mal. Which of the following is likely to be
Hakimov triad (gait apraxia, urinary inconfound on exam (image shows large ventricles) a. gait apraxia
b. cogwheeling c. expressive aphasia tinence, dementia) in normotensive hydrocephalus (NPH) 7/61
16. a patient undergoing chemotherapy treatment experiences nausea when approaching teh hospital
where the therapy is administered. This pairing is an example of a. operant conditioning b. conditioned
response c. unconditioned stimulus d. negative reinforcement e. compensatory response conditioned
response 17.
Question: Which of the following patient character- male gender istics is correlated with the greatest
risk of completed suicide in the year following deliberate self harm behavior a. male gender b. tx
setting c. minority race/ethnicity d. younger adult age group e. cutting as the initial self harm means
18. Other than causing an index episode of substance induced psychosis, which of the following
substances is associated with the highest rate of conversion to schizophrenia or bipolar disorder a.
opioid b. alcohol Cannabis d. alien hand syndrome e. reduced vertical eye movements 8/61 c. cocaine'
d. cannabis e. hallucinogens
19. Ketamine's rapid antidepressant effect is Glutamate thought to be due to action on which
neurotransmitter pathway a. serotonin b. histamine c. dopamine d. glutamate e. norepinephrine
20. Neurogenesis in adults occurs in a limited number of brain regions, including which of the
following a. globus pallidus b. lateral ventrical c. substantia nigra d. locus coeruleus e. subthalamic
nucleus
21. N-methyl-d-aspartate (NMDA) receptor antagonist Ketamine is a noncompetitive open channel
inhibitor of the NMDA receptor; specifically, it binds to the phencyclidine site of the NMDA receptor
Lateral Ventricle Which part of the brain is responsible for neurogenesis?
Answer:
Neurogenesis is the formation of neurons de novo-the hallmark of a developing brain. In an adult
animal brain, neurogenesis is said to occur in the lateral subventricular zone (SVZ) and the DG of the
hippocampus The subventricular zone (SVZ) is one of two regions where neurogenesis persists in the
postnatal brain. The SVZ, located along the lateral ventricle, is the largest neurogenic zone in the brain
that contains multiple cell populations including astrocyte-like cells and neuroblasts 9/61
Question: 1. Pharmacogenetic testing is recommend- Carbamazepine ed in patients of Asian and
Southeast Asian ancestry prior to initiation which of Before starting: individuals with ancestry the
following?
Answer:
a. Imipramine b. lamotrigene c. Fluvoxamine d. Valproic Acid e. Carbamazepine 2.
Question: Which of the following pathways is implicated in the development of tardive dyskinesia a.
mesolimbic b. nigrostriatal c. mesocortical d. tuberoinfundibular e. incertohypothalamic
3. Which of the following hormones is involved in osmoregulation, food intake, and female and sexual
behaviors a. oxytocin b. estrogen c. melatonin d. testosterone e. progesterone
4. Which of the following has dominant inheritance a. wilson disease across broad areas of asia should
consider screening for the presence of HLAB*1502 allele; those with the HLA-B*1502 allele should
not be treated with carbamazepine Nigrostriatal Oxytocin a. wilson disease - AR b. PKU - AR
C. Sickle Cell Disease - AR 2/61 b. PKU
C. Sickle Cell Disease d. Huntington Disease e. Cri-Du-Chat
5. Posttraumatic stress disorder has been most commonly associated with reduced volume on MRI in
which brain region a. thalamus b. hippocampus c. hypothalamus d. cerebral cortex e. corpus callosum
6. A patient with Alzheimer dx struggles to take oral acetylcholinesterase inhibitors due to severe
nausea and vomiting. Which of the following medications offers an alternative route of administration
that may improve tolerability?
Answer:
a. tacrine b. donepezil c. memantine d. rivastigmine e. galantamine
7. Evidence best supports use of acupuncture for which of the following indications a. anxiety b.
insomnia c. depression d. Huntington Disease -AD e. Cri-Du-Chat - most not inherited, random
Hippocampus Rivastigmine - Transdermal dosage available Pain management 3/61 d. pain
management e. smoking cessation 8.
Question: Which of the following brain waves is most associated with alertness in an adult waking
EEG?
Answer:
a. beta b. delta c. theta d. alpha e. gamma
9. Self report tolls adminitered prior to the session aid the initial psychiatric interview by a. promoting
standardized tx plans b. increasing the efficiency of the office visit c. minimizing the risk of a
pre-conceived diagnosis d. reducing the time needed to interview the patient e. limiting false positive
and false negative identifications 10.
,Question: Which of the following symptoms must be present to make a diagnosis of manic episode a.
grandiosity b. distractibility c. flight of ideas Beta b. increasing the eflciency of the oflce visit increased
activity of energy You have an abnormal, long-lasting elevated expression of emotion along with a
high degree of energy and activity that lasts for at least one week and is present most of the day, nearly
every day. 4/61 d. decreased need for sleep
e. increased activity or energy 11. a 44 year old patient presents with extreme fatigue and depression.
Physical examination reveals darkening of skin e. adrenocorticotropic hormone stimulation test and
mucosa. Which of hte following tests This test is helpful in determining if the adrenwould most likely
lead to the diagnosis a. Porphobilinogen b. Vanillylmandelic acid c. Thyroid Stimulating Hormone d.
5-hydroxyindoleacetic acid al and pituitary glands are normal. It is most often used when adrenal gland
disorders, such as Addison's disease or pituitary insuflciency, are suspected. Normal Values: An
increase in cortisol after stimulation by ACTH is e. adrenocorticotropic hormone stimula- normal. tion
test
12. Buprenorphine is combined with Naloxone in oral formulations to reduce which of the following a.
cravings b. side effects c. abuse potential d. drug interactions e. lethality in overdose Abuse potential
Buprenorphine + Naloxone = suboxone Buprenorphine is a partial agonist (thus can cause immediate
withdrawal in a pt currently taking opioids but can relieve withdrawal if a pt is already experiencing it)
and an antagonist at the kappa opioid receptor Naloxone is a mu receptor antagonist and can therefore
block the effects of buprenorphine but because it has poor sublingual bioavailability, it does not
interfere with buprenorphine's effects when used properly as it does 5/61
13. Childhood trauma, which increases risk for depression and PTSD has been correlated with an
increase in the expression of which of hte following genes a. AKT1
B. SERT
C. FRM1
D. ApoE2
E. FKBP5 have good parenteral bioavailability Thus if one tries to administer suboxone IV, naloxone
will prevent any rewarding effects from buprenorphine FKBP5 What does the FKBP5 gene do?
Answer:
The FKBP5 gene encodes a molecular co-chaperone of the glucocorticoid receptor complex, which
modulates intracellular glucocorticoid signaling and plays an important role in homeostatic regulation
of the stress response a. The AKT1 gene has also been implicated in schizophrenia by association
studies and decreased protein expression in the brains of schizophrenic patients. b. c. Fragile X
syndrome (FXS) is a genetic disorder. FXS is caused by changes in a gene called Fragile X Messenger
Ribonucleoprotein 1 (FMR1). FMR1 usually makes a protein called FMRP that is needed for brain
development. People who have FXS do not make this protein. d. 6/61 14.
, Question: Which of the following is the most compelling argument for allowing all clinicians to have
unrestricted access to mental health information in EHR?
Answer:
A. privacy rights do not apply to patients admitted involuntarily b. Confidentiality of EHR info is less
relevant in the era of big data c. unrestricted access to psychiatric records lowers the stigma of mental
illness d. social media acceptance has diminished the concern for privacy and confidentiality e.
Readmission rates tend to be lower in hospitals with unrestricted access to the EHR 15. 65 YO W
PROGRESSIVE COGNITIVE DE CLINE. Lumbar puncture shows ordinary opening pressure and is
otherwise nore. Readmission rates tend to be lower in hospitals with unrestricted access to the EHR
A. gait apraxia Gait apraxia is most commonly a part of the mal. Which of the following is likely to be
Hakimov triad (gait apraxia, urinary inconfound on exam (image shows large ventricles) a. gait apraxia
b. cogwheeling c. expressive aphasia tinence, dementia) in normotensive hydrocephalus (NPH) 7/61
16. a patient undergoing chemotherapy treatment experiences nausea when approaching teh hospital
where the therapy is administered. This pairing is an example of a. operant conditioning b. conditioned
response c. unconditioned stimulus d. negative reinforcement e. compensatory response conditioned
response 17.
Question: Which of the following patient character- male gender istics is correlated with the greatest
risk of completed suicide in the year following deliberate self harm behavior a. male gender b. tx
setting c. minority race/ethnicity d. younger adult age group e. cutting as the initial self harm means
18. Other than causing an index episode of substance induced psychosis, which of the following
substances is associated with the highest rate of conversion to schizophrenia or bipolar disorder a.
opioid b. alcohol Cannabis d. alien hand syndrome e. reduced vertical eye movements 8/61 c. cocaine'
d. cannabis e. hallucinogens
19. Ketamine's rapid antidepressant effect is Glutamate thought to be due to action on which
neurotransmitter pathway a. serotonin b. histamine c. dopamine d. glutamate e. norepinephrine
20. Neurogenesis in adults occurs in a limited number of brain regions, including which of the
following a. globus pallidus b. lateral ventrical c. substantia nigra d. locus coeruleus e. subthalamic
nucleus
21. N-methyl-d-aspartate (NMDA) receptor antagonist Ketamine is a noncompetitive open channel
inhibitor of the NMDA receptor; specifically, it binds to the phencyclidine site of the NMDA receptor
Lateral Ventricle Which part of the brain is responsible for neurogenesis?
Answer:
Neurogenesis is the formation of neurons de novo-the hallmark of a developing brain. In an adult
animal brain, neurogenesis is said to occur in the lateral subventricular zone (SVZ) and the DG of the
hippocampus The subventricular zone (SVZ) is one of two regions where neurogenesis persists in the
postnatal brain. The SVZ, located along the lateral ventricle, is the largest neurogenic zone in the brain
that contains multiple cell populations including astrocyte-like cells and neuroblasts 9/61
