Psychopharmacology Final Exam Questions and Questions and Answers
Verified Solutions Latest Update
Question: 1. The process of releasing neurotransmitter molecules from the vesicles is known as and
occurs as a result of an influx of Exocytosis; Ca2+ 2. Depot binding is said to occur when drugs Bind to
inactive sites
3. During the period, no additional action potentials can be created Absolute refractory
4. Neural transmission is generally within a sin- Electrical; chemical gle neuron and between neurons.
5. The most common type of synapse in the brain is Axodendritic the synapse
6. Neurons rely on for protection, metabolic support and insulation Glial cells
7. Which of the following factors does NOT affect the Drug action pharmokinetics of a drug?
Answer:
A) Route of Administration
B) Lipid solubility
C) Depot binding
D) Drug action
8. The sac-like structures in the presynaptic terminal Synaptic vesicles; neurotransmitare called and are
filled with
9. In addition to environmental and sensory stimuli, psychoactive drugs can trigger long-lasting
changes in neuronal connectivity. Collectively, these changes are termed ter molecules Synaptic
plasticity 2/23
10. Microtubules 3/23 Axonal transport of proteins occurs along a track formed by 11.
Question: When activated, somatodendritic autoreceptors Reduce the rate of cell firing
12. If a substance is a neurotransmitter, stimulation of the presynaptic cell should have the same effect
as
13. In order for a substance to be considered a neu Direct application of the proposed substance to the
postsynaptic cell Vesicles containing the subrotransmitter it must meet several criteria. Which stance
should move down the of the following is NOT considered a criterion for neurotransmitter status?
Answer:
A) A synthetic mechanism should be present in the presynaptic cell
B) Vesicles containing the substance should move down the axon with the action potentials when the
neuron is stimulated
C) Receptors for the proposed substance should be present on the postsynaptic cell
D) A means for inactivating the substance should be present axon with the action potentials
, Question: When the neuron is stimulated
14. The Na+/K+ pump helps to maintain the by Resting membrane potential moving three Na+ ions in
and two K+ ions out of the cell
15. Activating a metabotropic receptor can result in all of the following except for
A) Opening of a G protein-gated ion channel
B) changes in the levels of a second messenger
C) Opening of an ion channel within the receptor
D) Changes in gene expression Changes in gene expression 4/23
16. Drug metabolism mostly occurs in the and usually makes a drug more soluble.
17. The is best described as a result of the selective permeability of the neuronal membrane and the
uneven distribution of ions inside and outside the cell.
18. After drug administration has occurred, the amount of drug in the blood that is free to bind at
specific target sites is/are referred to as Liver; Water Resting membrane potential Bioavailability
19. In the dose-response curve, a decrease in potency To the right is indicated by a shift 20. refer(s) to
specific molecular changes that occur when a drug binds to a particular target site or receptor, while are
the resulting widespread alterations in function.
21. Selective blockade of terminal autoreceptors for DA would lead to a(n)
22. Prior to neurotransmitter release, vesicles are transported to specialized regions of the presynaptic
terminal called zones, where they bind to the terminal in a process known as. Drug action; drug effects
Increase in neurotransmitter release Priming, exocytosis.
23. Steroid hormones bind to receptors, which Intracellular; Transcription facact as when activated, and
regulate gene expression tors 5/23
24. The absorption of a drug depends on all of the following except
A) Lipid solubility
B) Ionization
C) Body temperature
D) The concentration of the drug
25. Drugs administered are absorbed the most rapidly Body temperature Intravenously
26. Most drugs and neurotransmitters act upon Membrane-bound receptors
27. Biotransformation of drugs can result in the formation of, which enter the circulation and cause.
28. The primary "input zone" of the neuron is generally considered to be the
29. Inactivation of neurotransmitters can be accomplished by all of the following except for
A) Enzymatic breakdown in the synaptic cleft
B) transport back into the presynaptic cell
C) Transport into the postsynaptic cell
D) Transport into nearby glial cells. Active metabolites; prolonged drug action Dendrites Transport
into the postsynaptic cell
30. In a myelinated axon, action potentials are regen- At gaps in the myelin known as erated
31. The absolute refractory period occurs because channels cannot be opened, and the relative
refractory period occurs because nodes of Ranvier Voltage gated Na+; Voltage-gated K+ channels
Verified Solutions Latest Update
Question: 1. The process of releasing neurotransmitter molecules from the vesicles is known as and
occurs as a result of an influx of Exocytosis; Ca2+ 2. Depot binding is said to occur when drugs Bind to
inactive sites
3. During the period, no additional action potentials can be created Absolute refractory
4. Neural transmission is generally within a sin- Electrical; chemical gle neuron and between neurons.
5. The most common type of synapse in the brain is Axodendritic the synapse
6. Neurons rely on for protection, metabolic support and insulation Glial cells
7. Which of the following factors does NOT affect the Drug action pharmokinetics of a drug?
Answer:
A) Route of Administration
B) Lipid solubility
C) Depot binding
D) Drug action
8. The sac-like structures in the presynaptic terminal Synaptic vesicles; neurotransmitare called and are
filled with
9. In addition to environmental and sensory stimuli, psychoactive drugs can trigger long-lasting
changes in neuronal connectivity. Collectively, these changes are termed ter molecules Synaptic
plasticity 2/23
10. Microtubules 3/23 Axonal transport of proteins occurs along a track formed by 11.
Question: When activated, somatodendritic autoreceptors Reduce the rate of cell firing
12. If a substance is a neurotransmitter, stimulation of the presynaptic cell should have the same effect
as
13. In order for a substance to be considered a neu Direct application of the proposed substance to the
postsynaptic cell Vesicles containing the subrotransmitter it must meet several criteria. Which stance
should move down the of the following is NOT considered a criterion for neurotransmitter status?
Answer:
A) A synthetic mechanism should be present in the presynaptic cell
B) Vesicles containing the substance should move down the axon with the action potentials when the
neuron is stimulated
C) Receptors for the proposed substance should be present on the postsynaptic cell
D) A means for inactivating the substance should be present axon with the action potentials
, Question: When the neuron is stimulated
14. The Na+/K+ pump helps to maintain the by Resting membrane potential moving three Na+ ions in
and two K+ ions out of the cell
15. Activating a metabotropic receptor can result in all of the following except for
A) Opening of a G protein-gated ion channel
B) changes in the levels of a second messenger
C) Opening of an ion channel within the receptor
D) Changes in gene expression Changes in gene expression 4/23
16. Drug metabolism mostly occurs in the and usually makes a drug more soluble.
17. The is best described as a result of the selective permeability of the neuronal membrane and the
uneven distribution of ions inside and outside the cell.
18. After drug administration has occurred, the amount of drug in the blood that is free to bind at
specific target sites is/are referred to as Liver; Water Resting membrane potential Bioavailability
19. In the dose-response curve, a decrease in potency To the right is indicated by a shift 20. refer(s) to
specific molecular changes that occur when a drug binds to a particular target site or receptor, while are
the resulting widespread alterations in function.
21. Selective blockade of terminal autoreceptors for DA would lead to a(n)
22. Prior to neurotransmitter release, vesicles are transported to specialized regions of the presynaptic
terminal called zones, where they bind to the terminal in a process known as. Drug action; drug effects
Increase in neurotransmitter release Priming, exocytosis.
23. Steroid hormones bind to receptors, which Intracellular; Transcription facact as when activated, and
regulate gene expression tors 5/23
24. The absorption of a drug depends on all of the following except
A) Lipid solubility
B) Ionization
C) Body temperature
D) The concentration of the drug
25. Drugs administered are absorbed the most rapidly Body temperature Intravenously
26. Most drugs and neurotransmitters act upon Membrane-bound receptors
27. Biotransformation of drugs can result in the formation of, which enter the circulation and cause.
28. The primary "input zone" of the neuron is generally considered to be the
29. Inactivation of neurotransmitters can be accomplished by all of the following except for
A) Enzymatic breakdown in the synaptic cleft
B) transport back into the presynaptic cell
C) Transport into the postsynaptic cell
D) Transport into nearby glial cells. Active metabolites; prolonged drug action Dendrites Transport
into the postsynaptic cell
30. In a myelinated axon, action potentials are regen- At gaps in the myelin known as erated
31. The absolute refractory period occurs because channels cannot be opened, and the relative
refractory period occurs because nodes of Ranvier Voltage gated Na+; Voltage-gated K+ channels
