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Wilkes University
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Where is Norepinephrine made in the brain? And what is its' fu
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nction? - ../
correct answer Locus Cerulus(Brain stem, responsible for medi
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cating SYMPATHETIC nervous system and stress responses)
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Hyperactivity of the norepinephrine system/increased locus cer
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ulus system is common in those with anxiety.
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-
Leads to hypervigilance, increased arousal, panic, and exaggera
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ted stress responses.
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What is the main function of GABA? -
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correct answer Primary function is inhibition at post synaptic n
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euron
-Induces calmness, relaxation, big role in anxiety disorders
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-Acted directly on by BDZ and barbituates
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,-Gaba_A and GABA_B ../ ../
What is agoraphobia and how is it treated? - correct answer -
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Fear of public places; where escape or obtaining help may be d
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ifficult
-Tx via CBT and SSRI
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GAD Tx? - correct answer 1st Line -
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SSRI (Escitalopram, Paroxetine, Duloxetine)
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2nd line -
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Buspar (Partial serotonin agonist at pre and post synapses) and
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SNRI (Venlafaxine)
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-Can consider short term course of BDZ Rx
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Panic attack initial treatment? - correct answer Benzodiazepines
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, Panic Disorder 1st and 2ndline tx? - correct answer 1st line -
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SSRI or SNRI (Fluoxetine, Sertraline, or Venlafaxine)
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2nd line - TCAs (Clomipramine, imipramine)
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Adjunct tx- ../
Benzodiazepines, SHORT term only until other medications re
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ach therapeutic efficacy, Alprazolam SPECIFICALLY is FDA
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approved)
Social Phobia (Ex. performance Anxiety) -
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correct answer Fear of scrutiny by others or fear of acting in a
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humiliating or embarrassing way
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-CBT
1st line - SSRI or SNRI
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Betablockers (Atenolol 50-100mg) and Propranolol (20-
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40mg one hour prior to performance or public speaking) -
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AVOID in patients with COPD due to bronchospasm risk
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