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Fall
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First Line Treatments for alcohol use disorder (according to Stu
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dy Guide & Dynamed) -
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correct answer naltrexone and acamprosate
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Second Line Treatments for alcohol use disorder (according to
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study guide but not dynamed) -
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correct answer Disulfuram and Bupropion (not FDA approved
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for ETOH but second line according to study guide)
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Second Line Treatment for alcohol use disorder (according to
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Dynamed) - correct answer Disulfuram ../ ../ ../ ../
Other off label medications for alcohol use disorder according t
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o Dynamed - correct answer Topiramate, gabapentin, baclofen
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Other off label medications for alcohol use disorder according t
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o Stahl's - correct answer Topiramate, ondansetron
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, MOA of Naltrexone -
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correct answer Opioid Receptor Antagonist
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MOA of Acamprosate - correct answer - weak GABAa agonist
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- weak NMDA antagonist
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(does not prevent withdrawal symptoms)
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MOA of Disulfuram -
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correct answer inhibits enzyme (aldehyde dehydrogenase) in th
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e liver../
Bupropions role in alcohol use disorder -
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correct answer Can diminish cravings for etoh, treat underlyin
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g anxiety/depression
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Safety Risk associated with bupropion and etoh -
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correct answer bupropion increases the risk of seizures in thos
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e going through etoh withdrawal
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