Test bank for Tietz Fundamentals of Clinical Chemistry and
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ss Molecular Diagnostics,
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8th Edition by Nader Rifai, PhD
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Chapters 1 - 49 ss ss ss ss
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
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Table of contents:
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I. Principles Of Laboratory Medicine
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Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
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Chapter 3. Clinical Evaluation of Methods
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Chapter 4. Evidence-Based Laboratory Medicine
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Chapter 5. Establishment and Use of Reference Values
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Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
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Chapter 7. Quality Management
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II. Analytical Techniques And Instrumentation
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Chapter 8. Principles of Basic Techniques and Laboratory Safety
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Chapter 9. Optical Techniques
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Chapter 10. Electrochemistry and Chemical Sensors
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Chapter 11. Electrophoresis
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Chapter 12. Chromatography
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Chapter 13. Mass Spectrometry
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Chapter 14. Enzyme and Rate Analyses
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Chapter 15. Immunochemical Techniques
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Chapter 16 Automation ss ss
Chapter 17. Point-of-Care Instrumentation
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III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
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Chapter 19. Serum Enzymes
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Chapter 20. Tumor Markers and Cancer Genes
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Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
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Chapter 22. Carbohydrates
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Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
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Chapter 24. Electrolytes and Blood Gases
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Chapter 25. Hormones ss ss
Chapter 26. Catecholamines and Serotonin
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Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
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Chapter 28. Hemoglobin, Iron, and Bilirubin
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Chapter 29. Porphyrins and Porphyrias
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Chapter 30. Therapeutic Drugs and Their Management
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Chapter 31. Clinical Toxicology
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Chapter 32. Toxic Metals
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IV. Pathophysiology
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Chapter 33. Diabetes ss ss
,Chapter 34. Cardiovascular Disease
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Chapter 35. Kidney Disease
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Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
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Chapter 37. Liver Disease
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Chapter 38. Gastrointestinal and Pancreatic Diseases
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Chapter 39. Disorders of Bone and Mineral Metabolism
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Chapter 40. Disorders of the Pituitary Gland
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Chapter 41. Disorders of the Adrenal Cortex
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Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
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Chapter 44. Pregnancy and Prenatal Testing
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Chapter 45. Newborn Screening and Inborn Errors of Metabolism
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Chapter 46. Pharmacogenetics
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V. Molecular Diagnostics
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Chapter 47. Principles of Molecular Biology
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Chapter 48. Nucleic Acid Techniques and Applications
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Chapter 49. Genomes and Nucleic Acid Alterations
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, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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TestBank
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MULTIPLE CHOICE ss
1. An individual working in a clinical chemistry laboratory is married to a sales representative
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who works for a company that sells chemistry laboratory supplies. When the laboratory
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manager requests a list of needed supplies, cost of supplies, and vendors, this individual
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onlyrecommends the spouse’s company as the vendor. This is considered to be a(n):
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a. accounting issue. ss
b. possible conflict of interest. ss ss ss
c. maintenance of confidentiality issue. ss ss ss
d. problem with resource allocation. ss ss ss
ANS: B ss
Concern has been raised over the interrelationships between practitioners in the medical
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fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
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Similarly, relationships have been scrutinized between clinical laboratorians and
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manufacturers and providers of diagnostic equipment and supplies. These concerns led the
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National Institutes of Health (NIH) in 1995 to require official institutional review of financial
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disclosure by researchers and management of situations in which disclosure indicates
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potentialconflicts of interest.
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DIF: 1 REF: Page 4-5 ss ss ss ss OBJ: 6 | 7 ss ss ss
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
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the pain following her recent surgery. A friend of the patient claims that the same
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painkiller―worked wonders‖ to reduce her pain after the same surgery. The physician
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states that the difference in the effect of the drug might be caused by , which is studied
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in pharmacogenetics.
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a. epidemiology
b. an inherited disease ss ss
c. a conflict of interest
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d. a genetic variation in drug-metabolizing enzymes
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ANS: D ss
Pharmacogenetics is the study of the genetic variation of drug metabolism ss ss ss ss ss ss ss ss ss ss
betweenindividuals.
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DIF: 1 REF: Page 3 ss ss ss ss OBJ: 1 ss
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
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name of a close friend printed on the bar-coded label. The genetic test that is ordered on
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thefriend’s sample would provide diagnostic information about a disorder that has a poor
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prognosis, and the test is usually performed by John. He asks a fellow employee to
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analyzethe sample for him and not divulge the results. This ethical issue concerns:
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a. confidentiality of patient genetic and medical information. ss ss ss ss ss ss
b. a conflict of interest.
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c. resource allocation. ss
d. diagnostic accuracy. ss
ss ss ss ss ss ss ss ss
ss Molecular Diagnostics,
ss ss
8th Edition by Nader Rifai, PhD
ss ss ss ss ss ss
Chapters 1 - 49 ss ss ss ss
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
ss ss ss ss ss ss ss ss
ss
ss ss
Table of contents:
ss ss
I. Principles Of Laboratory Medicine
ss ss ss ss
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
ss ss ss ss ss ss ss ss
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
ss ss ss ss ss ss ss ss ss ss ss
Chapter 3. Clinical Evaluation of Methods
ss ss ss ss ss
Chapter 4. Evidence-Based Laboratory Medicine
ss ss ss ss
Chapter 5. Establishment and Use of Reference Values
ss ss ss ss ss ss ss
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
ss ss ss ss ss ss ss ss
Chapter 7. Quality Management
ss ss ss
II. Analytical Techniques And Instrumentation
ss ss ss ss
Chapter 8. Principles of Basic Techniques and Laboratory Safety
ss ss ss ss ss ss ss ss
Chapter 9. Optical Techniques
ss ss ss
Chapter 10. Electrochemistry and Chemical Sensors
ss ss ss ss ss
Chapter 11. Electrophoresis
ss ss
Chapter 12. Chromatography
ss ss
Chapter 13. Mass Spectrometry
ss ss ss
Chapter 14. Enzyme and Rate Analyses
ss ss ss ss ss
Chapter 15. Immunochemical Techniques
ss ss ss
Chapter 16 Automation ss ss
Chapter 17. Point-of-Care Instrumentation
ss ss ss
III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
ss ss ss ss ss ss
Chapter 19. Serum Enzymes
ss ss ss
Chapter 20. Tumor Markers and Cancer Genes
ss ss ss ss ss ss
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
ss ss ss ss ss ss ss ss ss ss ss
Chapter 22. Carbohydrates
ss ss
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
ss ss ss ss ss ss ss ss ss
Chapter 24. Electrolytes and Blood Gases
ss ss ss ss ss
Chapter 25. Hormones ss ss
Chapter 26. Catecholamines and Serotonin
ss s s ss ss
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
ss s s ss ss ss ss
Chapter 28. Hemoglobin, Iron, and Bilirubin
ss ss ss ss ss
Chapter 29. Porphyrins and Porphyrias
ss ss ss ss
Chapter 30. Therapeutic Drugs and Their Management
ss ss ss ss ss ss
Chapter 31. Clinical Toxicology
ss ss ss
Chapter 32. Toxic Metals
ss s s ss
IV. Pathophysiology
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Chapter 33. Diabetes ss ss
,Chapter 34. Cardiovascular Disease
ss s s ss
Chapter 35. Kidney Disease
ss ss ss
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
ss s s ss ss ss ss ss ss ss ss
Chapter 37. Liver Disease
ss ss ss ss
Chapter 38. Gastrointestinal and Pancreatic Diseases
ss s s ss ss ss
Chapter 39. Disorders of Bone and Mineral Metabolism
ss ss ss ss ss ss ss ss
Chapter 40. Disorders of the Pituitary Gland
ss ss ss ss ss ss ss
Chapter 41. Disorders of the Adrenal Cortex
ss s s ss ss ss ss
Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
ss s s ss
Chapter 44. Pregnancy and Prenatal Testing
ss ss ss ss ss ss
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
ss s s ss ss ss ss ss ss
Chapter 46. Pharmacogenetics
ss ss
V. Molecular Diagnostics
s s ss
Chapter 47. Principles of Molecular Biology
ss ss ss ss ss
Chapter 48. Nucleic Acid Techniques and Applications
ss ss ss ss ss ss
Chapter 49. Genomes and Nucleic Acid Alterations
ss ss ss ss ss ss
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
ss ss ss ss ss ss ss ss
TestBank
ss s
MULTIPLE CHOICE ss
1. An individual working in a clinical chemistry laboratory is married to a sales representative
ss ss ss ss ss ss ss ss ss ss ss ss ss
who works for a company that sells chemistry laboratory supplies. When the laboratory
ss ss ss ss ss ss ss ss ss ss ss ss ss
manager requests a list of needed supplies, cost of supplies, and vendors, this individual
ss ss ss ss ss ss ss ss ss ss ss ss ss ss
onlyrecommends the spouse’s company as the vendor. This is considered to be a(n):
ss s ss ss ss ss ss ss ss ss ss ss ss ss
a. accounting issue. ss
b. possible conflict of interest. ss ss ss
c. maintenance of confidentiality issue. ss ss ss
d. problem with resource allocation. ss ss ss
ANS: B ss
Concern has been raised over the interrelationships between practitioners in the medical
ss ss ss ss ss ss ss ss ss ss ss
fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
ss s ss ss ss ss ss ss ss ss ss ss ss
Similarly, relationships have been scrutinized between clinical laboratorians and
ss ss ss ss ss ss ss ss
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
ss ss ss ss ss ss ss ss ss ss ss ss
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
ss ss ss ss ss ss ss ss ss ss ss ss ss ss
disclosure by researchers and management of situations in which disclosure indicates
ss ss ss ss ss ss ss ss ss ss ss
potentialconflicts of interest.
ss s ss ss
DIF: 1 REF: Page 4-5 ss ss ss ss OBJ: 6 | 7 ss ss ss
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
ss ss ss ss ss ss ss ss ss ss ss ss ss ss
the pain following her recent surgery. A friend of the patient claims that the same
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
painkiller―worked wonders‖ to reduce her pain after the same surgery. The physician
ss s ss ss ss ss ss ss ss ss ss ss ss
states that the difference in the effect of the drug might be caused by , which is studied
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
in pharmacogenetics.
ss ss
a. epidemiology
b. an inherited disease ss ss
c. a conflict of interest
ss ss ss
d. a genetic variation in drug-metabolizing enzymes
ss ss ss ss ss
ANS: D ss
Pharmacogenetics is the study of the genetic variation of drug metabolism ss ss ss ss ss ss ss ss ss ss
betweenindividuals.
ss s
DIF: 1 REF: Page 3 ss ss ss ss OBJ: 1 ss
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
ss ss ss ss ss ss ss ss ss ss ss ss ss ss
name of a close friend printed on the bar-coded label. The genetic test that is ordered on
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
thefriend’s sample would provide diagnostic information about a disorder that has a poor
ss s ss ss ss ss ss ss ss ss ss ss ss ss
prognosis, and the test is usually performed by John. He asks a fellow employee to
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
analyzethe sample for him and not divulge the results. This ethical issue concerns:
ss s ss ss ss ss ss ss ss ss ss ss ss ss
a. confidentiality of patient genetic and medical information. ss ss ss ss ss ss
b. a conflict of interest.
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c. resource allocation. ss
d. diagnostic accuracy. ss