What are the only 2 things opioid users cannot develop tolerance to?
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Pupil contriction and constipation
Why is it challenging to use cannabis for pharmacological reasons?
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Challenging to separate beneficial effects from psychotropic effects
Pros and cons of vaping cannabis
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Pros: potentially produces smaller amounts of toxic substances, may
decrease negative respiratory effects associated with smoking, discrete
Cons: long-term health effects unknown, degree of contamination
unknown, increased risk of consumption and poisoning children
Benefit of Zolpidem over benzodiazepines
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Don't disturb REM sleep as much
Effect of high doses of barituates on cardiovascular system
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depress the cardiovascular system, slow HR lower BP
Dose-dependent
Tolerance can develop to what effects of cannabis
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psychoactive properties, effects on the cardiovascular system, impairment
of performance and cognitive function
,Describe the detailed metabolism of alcohol
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1. ethanol converted to acetaldehyde by ADH (rate controlling step)
2. MEOS, part of P450 system, contributes to the removal of ethanol
especially at high doses when ADH is saturated
3. acetaldehyde converted to acetate/acetic acid by ALDH
4. acetic acid/acetate metabolized by tissues into CO2 and H2O
CB2 receptors
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not involved in the psychotomimetic effects of THC
Binding of THC to CB2 receptors on lymphocytes may be responsible for
the immunosuppressive properties of THC
medium-low doses of sedative hypnotics cause
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relieve anxiety, decrease activity, moderate excitement, calm
Cannabis and sex
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, Decreases FSH and LH
Decreased testosterone in men, reduction in sex drive, decreased sperm
count
Disruption of ovarian cycle in women
Can addiction occur with benzodiazepines?
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Can develop in some users
Cross-tolerance occurs between opioids when
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They act on the same receptor
i.e. heroin and methadone
Activation of the barbiturate receptor
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Increases the duration of the opening of the chloride channel
High dose of sedative hypnotics
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Pupil contriction and constipation
Why is it challenging to use cannabis for pharmacological reasons?
Give this one a try later!
Challenging to separate beneficial effects from psychotropic effects
Pros and cons of vaping cannabis
,Give this one a try later!
Pros: potentially produces smaller amounts of toxic substances, may
decrease negative respiratory effects associated with smoking, discrete
Cons: long-term health effects unknown, degree of contamination
unknown, increased risk of consumption and poisoning children
Benefit of Zolpidem over benzodiazepines
Give this one a try later!
Don't disturb REM sleep as much
Effect of high doses of barituates on cardiovascular system
Give this one a try later!
depress the cardiovascular system, slow HR lower BP
Dose-dependent
Tolerance can develop to what effects of cannabis
Give this one a try later!
psychoactive properties, effects on the cardiovascular system, impairment
of performance and cognitive function
,Describe the detailed metabolism of alcohol
Give this one a try later!
1. ethanol converted to acetaldehyde by ADH (rate controlling step)
2. MEOS, part of P450 system, contributes to the removal of ethanol
especially at high doses when ADH is saturated
3. acetaldehyde converted to acetate/acetic acid by ALDH
4. acetic acid/acetate metabolized by tissues into CO2 and H2O
CB2 receptors
Give this one a try later!
not involved in the psychotomimetic effects of THC
Binding of THC to CB2 receptors on lymphocytes may be responsible for
the immunosuppressive properties of THC
medium-low doses of sedative hypnotics cause
Give this one a try later!
relieve anxiety, decrease activity, moderate excitement, calm
Cannabis and sex
Give this one a try later!
, Decreases FSH and LH
Decreased testosterone in men, reduction in sex drive, decreased sperm
count
Disruption of ovarian cycle in women
Can addiction occur with benzodiazepines?
Give this one a try later!
Can develop in some users
Cross-tolerance occurs between opioids when
Give this one a try later!
They act on the same receptor
i.e. heroin and methadone
Activation of the barbiturate receptor
Give this one a try later!
Increases the duration of the opening of the chloride channel
High dose of sedative hypnotics
