ATI RN IMMUNE DISORDERS EXAM NEWEST
EVALUATED PRACTICE EXAM 100 QUESTIONS
2026-2027|ORIGINAL QUESTIONS & ANSWERS
|DETAILED RATIONALES |HINTED COMPLETE
EXAM PREP GRADED A+*INSTANT
DOWNLOAD PDF*
1. A nurse is assessing a client who has systemic lupus erythematosus
(SLE). Which finding should the nurse expect?
A. Butterfly-shaped facial rash
B. Increased appetite
C. Bradycardia
D. Yellow sclera
Answer: A. Butterfly-shaped facial rash
Rationale: SLE commonly causes a malar (“butterfly”) rash across the
cheeks and bridge of the nose.
2. A client with SLE reports increased fatigue and joint pain. Which
laboratory result is most consistent with SLE?
A. Positive antinuclear antibody (ANA)
B. Decreased C-reactive protein
C. Increased hemoglobin
D. Negative autoimmune antibodies
Answer: A. Positive antinuclear antibody (ANA)
,Rationale: ANA is commonly positive in clients with SLE and supports
the diagnosis of an autoimmune disorder.
3. Which instruction should the nurse give a client with SLE regarding
sunlight exposure?
A. Use tanning beds regularly.
B. Avoid sunscreen.
C. Wear protective clothing and use sunscreen.
D. Increase exposure during midday.
Answer: C. Wear protective clothing and use sunscreen.
Rationale: Ultraviolet exposure can trigger or worsen SLE
manifestations, so sun protection is important.
4. A nurse is caring for a client receiving prednisone for an
autoimmune disorder. Which finding requires priority assessment?
A. Increased appetite
B. Temperature of 38.5°C (101.3°F)
C. Mild facial rounding
D. Increased blood glucose
Answer: B. Temperature of 38.5°C (101.3°F)
Rationale: Corticosteroids suppress immune function and increase
infection risk. Fever can indicate a serious infection.
5. Which medication is commonly prescribed to reduce inflammation
in autoimmune disorders?
,A. Prednisone
B. Acetaminophen only
C. Furosemide
D. Potassium chloride
Answer: A. Prednisone
Rationale: Corticosteroids such as prednisone suppress inflammation
and immune activity.
6. A client with rheumatoid arthritis (RA) reports morning stiffness.
Which intervention should the nurse recommend?
A. Apply cold packs immediately after waking.
B. Take a warm shower in the morning.
C. Remain on bed rest throughout the day.
D. Avoid all physical activity.
Answer: B. Take a warm shower in the morning.
Rationale: Warmth can decrease joint stiffness and improve mobility,
particularly after periods of inactivity.
7. Which assessment finding is characteristic of rheumatoid arthritis?
A. Symmetric joint inflammation
B. Unilateral ankle edema only
C. Absence of joint pain
D. Sudden painless paralysis
Answer: A. Symmetric joint inflammation
Rationale: RA commonly affects joints symmetrically and causes pain,
swelling, stiffness, and reduced mobility.
, 8. Which medication is considered a disease-modifying antirheumatic
drug (DMARD) commonly used for RA?
A. Methotrexate
B. Acetaminophen
C. Diphenhydramine
D. Calcium carbonate
Answer: A. Methotrexate
Rationale: Methotrexate is a commonly used DMARD that reduces
autoimmune inflammation and can slow progression of RA.
9. A nurse is teaching a client taking methotrexate. Which statement
indicates understanding?
A. “I should report signs of infection.”
B. “I can stop the medication when my joints feel better.”
C. “This medication has no effect on my blood cells.”
D. “I should take extra doses when pain increases.”
Answer: A. “I should report signs of infection.”
Rationale: Methotrexate can suppress bone marrow and immune
function, increasing infection risk.
10. Which laboratory value should the nurse monitor for a client
receiving methotrexate?
A. CBC
B. Serum amylase only
EVALUATED PRACTICE EXAM 100 QUESTIONS
2026-2027|ORIGINAL QUESTIONS & ANSWERS
|DETAILED RATIONALES |HINTED COMPLETE
EXAM PREP GRADED A+*INSTANT
DOWNLOAD PDF*
1. A nurse is assessing a client who has systemic lupus erythematosus
(SLE). Which finding should the nurse expect?
A. Butterfly-shaped facial rash
B. Increased appetite
C. Bradycardia
D. Yellow sclera
Answer: A. Butterfly-shaped facial rash
Rationale: SLE commonly causes a malar (“butterfly”) rash across the
cheeks and bridge of the nose.
2. A client with SLE reports increased fatigue and joint pain. Which
laboratory result is most consistent with SLE?
A. Positive antinuclear antibody (ANA)
B. Decreased C-reactive protein
C. Increased hemoglobin
D. Negative autoimmune antibodies
Answer: A. Positive antinuclear antibody (ANA)
,Rationale: ANA is commonly positive in clients with SLE and supports
the diagnosis of an autoimmune disorder.
3. Which instruction should the nurse give a client with SLE regarding
sunlight exposure?
A. Use tanning beds regularly.
B. Avoid sunscreen.
C. Wear protective clothing and use sunscreen.
D. Increase exposure during midday.
Answer: C. Wear protective clothing and use sunscreen.
Rationale: Ultraviolet exposure can trigger or worsen SLE
manifestations, so sun protection is important.
4. A nurse is caring for a client receiving prednisone for an
autoimmune disorder. Which finding requires priority assessment?
A. Increased appetite
B. Temperature of 38.5°C (101.3°F)
C. Mild facial rounding
D. Increased blood glucose
Answer: B. Temperature of 38.5°C (101.3°F)
Rationale: Corticosteroids suppress immune function and increase
infection risk. Fever can indicate a serious infection.
5. Which medication is commonly prescribed to reduce inflammation
in autoimmune disorders?
,A. Prednisone
B. Acetaminophen only
C. Furosemide
D. Potassium chloride
Answer: A. Prednisone
Rationale: Corticosteroids such as prednisone suppress inflammation
and immune activity.
6. A client with rheumatoid arthritis (RA) reports morning stiffness.
Which intervention should the nurse recommend?
A. Apply cold packs immediately after waking.
B. Take a warm shower in the morning.
C. Remain on bed rest throughout the day.
D. Avoid all physical activity.
Answer: B. Take a warm shower in the morning.
Rationale: Warmth can decrease joint stiffness and improve mobility,
particularly after periods of inactivity.
7. Which assessment finding is characteristic of rheumatoid arthritis?
A. Symmetric joint inflammation
B. Unilateral ankle edema only
C. Absence of joint pain
D. Sudden painless paralysis
Answer: A. Symmetric joint inflammation
Rationale: RA commonly affects joints symmetrically and causes pain,
swelling, stiffness, and reduced mobility.
, 8. Which medication is considered a disease-modifying antirheumatic
drug (DMARD) commonly used for RA?
A. Methotrexate
B. Acetaminophen
C. Diphenhydramine
D. Calcium carbonate
Answer: A. Methotrexate
Rationale: Methotrexate is a commonly used DMARD that reduces
autoimmune inflammation and can slow progression of RA.
9. A nurse is teaching a client taking methotrexate. Which statement
indicates understanding?
A. “I should report signs of infection.”
B. “I can stop the medication when my joints feel better.”
C. “This medication has no effect on my blood cells.”
D. “I should take extra doses when pain increases.”
Answer: A. “I should report signs of infection.”
Rationale: Methotrexate can suppress bone marrow and immune
function, increasing infection risk.
10. Which laboratory value should the nurse monitor for a client
receiving methotrexate?
A. CBC
B. Serum amylase only
