ATI RN PHAMARCOLOGY EXAM NEWEST
EVALUATED PRACTICE EXAM 100 QUESTIONS
2026-2027|ORIGINAL QUESTIONS & ANSWERS
|DETAILED RATIONALES |HINTED COMPLETE
EXAM PREP GRADED A+*INSTANT DOWNLOAD
PDF*
1. Digoxin
A nurse is assessing a client who takes digoxin. Which finding should
the nurse recognize as a possible manifestation of digoxin toxicity?
A. Hypertension
B. Increased appetite
C. Yellow-green visual disturbances
D. Increased urinary output
Answer: C. Yellow-green visual disturbances
Rationale: Visual disturbances, nausea, vomiting, anorexia, and
dysrhythmias can indicate digoxin toxicity. The nurse should withhold
the medication and notify the provider when toxicity is suspected.
2. Furosemide
A nurse is administering furosemide to a client. Which laboratory value
is most important to monitor?
A. Calcium
B. Potassium
C. Hemoglobin
D. Platelets
,Answer: B. Potassium
Rationale: Furosemide is a loop diuretic that can cause significant
potassium loss, increasing the risk for hypokalemia and dysrhythmias.
3. Warfarin
A client taking warfarin asks which laboratory test is used to monitor
therapeutic effectiveness. Which response should the nurse provide?
A. aPTT
B. INR
C. Troponin
D. Platelet count
Answer: B. INR
Rationale: Warfarin therapy is monitored using prothrombin time
expressed as the international normalized ratio (INR).
4. Heparin
Which medication should the nurse prepare to administer for severe
heparin-induced bleeding?
A. Vitamin K
B. Protamine sulfate
C. Acetylcysteine
D. Naloxone
Answer: B. Protamine sulfate
Rationale: Protamine sulfate is the antidote for unfractionated
heparin and can reverse excessive anticoagulation.
,5. Insulin
A client receives regular insulin at 0730. When should the nurse
anticipate its greatest effect?
A. 0800
B. 0830
C. 0930
D. 1430
Answer: C. 0930
Rationale: Regular insulin has an onset of approximately 30–60 min
and peaks at about 2–4 hr, although timing can vary by formulation
and client factors.
6. Metformin
Which instruction should the nurse provide to a client taking
metformin?
A. Take the medication on an empty stomach.
B. Avoid monitoring blood glucose.
C. Take it with meals to reduce gastrointestinal effects.
D. Expect severe hypoglycemia as the primary adverse effect.
Answer: C. Take it with meals to reduce gastrointestinal effects.
Rationale: Metformin is generally taken with meals to reduce
gastrointestinal adverse effects. Renal function should also be
monitored because of the risk of lactic acidosis in susceptible clients.
, 7. Levothyroxine
Which instruction is appropriate for a client prescribed levothyroxine?
A. Take it at bedtime with food.
B. Take it in the morning on an empty stomach.
C. Stop taking it when symptoms improve.
D. Take it with an iron supplement.
Answer: B. Take it in the morning on an empty stomach.
Rationale: Levothyroxine is usually taken consistently in the morning
on an empty stomach. Calcium and iron can interfere with absorption
and should generally be separated.
8. Liothyronine
A client taking thyroid hormone reports palpitations, tremors, and
insomnia. What should the nurse suspect?
A. Hypothyroidism
B. Hyperthyroidism from excessive replacement
C. Hypoglycemia
D. Adrenal insufficiency
Answer: B. Hyperthyroidism from excessive replacement
Rationale: Excess thyroid hormone can cause manifestations such as
tachycardia, palpitations, tremors, nervousness, heat intolerance, and
insomnia.
9. Prednisone
EVALUATED PRACTICE EXAM 100 QUESTIONS
2026-2027|ORIGINAL QUESTIONS & ANSWERS
|DETAILED RATIONALES |HINTED COMPLETE
EXAM PREP GRADED A+*INSTANT DOWNLOAD
PDF*
1. Digoxin
A nurse is assessing a client who takes digoxin. Which finding should
the nurse recognize as a possible manifestation of digoxin toxicity?
A. Hypertension
B. Increased appetite
C. Yellow-green visual disturbances
D. Increased urinary output
Answer: C. Yellow-green visual disturbances
Rationale: Visual disturbances, nausea, vomiting, anorexia, and
dysrhythmias can indicate digoxin toxicity. The nurse should withhold
the medication and notify the provider when toxicity is suspected.
2. Furosemide
A nurse is administering furosemide to a client. Which laboratory value
is most important to monitor?
A. Calcium
B. Potassium
C. Hemoglobin
D. Platelets
,Answer: B. Potassium
Rationale: Furosemide is a loop diuretic that can cause significant
potassium loss, increasing the risk for hypokalemia and dysrhythmias.
3. Warfarin
A client taking warfarin asks which laboratory test is used to monitor
therapeutic effectiveness. Which response should the nurse provide?
A. aPTT
B. INR
C. Troponin
D. Platelet count
Answer: B. INR
Rationale: Warfarin therapy is monitored using prothrombin time
expressed as the international normalized ratio (INR).
4. Heparin
Which medication should the nurse prepare to administer for severe
heparin-induced bleeding?
A. Vitamin K
B. Protamine sulfate
C. Acetylcysteine
D. Naloxone
Answer: B. Protamine sulfate
Rationale: Protamine sulfate is the antidote for unfractionated
heparin and can reverse excessive anticoagulation.
,5. Insulin
A client receives regular insulin at 0730. When should the nurse
anticipate its greatest effect?
A. 0800
B. 0830
C. 0930
D. 1430
Answer: C. 0930
Rationale: Regular insulin has an onset of approximately 30–60 min
and peaks at about 2–4 hr, although timing can vary by formulation
and client factors.
6. Metformin
Which instruction should the nurse provide to a client taking
metformin?
A. Take the medication on an empty stomach.
B. Avoid monitoring blood glucose.
C. Take it with meals to reduce gastrointestinal effects.
D. Expect severe hypoglycemia as the primary adverse effect.
Answer: C. Take it with meals to reduce gastrointestinal effects.
Rationale: Metformin is generally taken with meals to reduce
gastrointestinal adverse effects. Renal function should also be
monitored because of the risk of lactic acidosis in susceptible clients.
, 7. Levothyroxine
Which instruction is appropriate for a client prescribed levothyroxine?
A. Take it at bedtime with food.
B. Take it in the morning on an empty stomach.
C. Stop taking it when symptoms improve.
D. Take it with an iron supplement.
Answer: B. Take it in the morning on an empty stomach.
Rationale: Levothyroxine is usually taken consistently in the morning
on an empty stomach. Calcium and iron can interfere with absorption
and should generally be separated.
8. Liothyronine
A client taking thyroid hormone reports palpitations, tremors, and
insomnia. What should the nurse suspect?
A. Hypothyroidism
B. Hyperthyroidism from excessive replacement
C. Hypoglycemia
D. Adrenal insufficiency
Answer: B. Hyperthyroidism from excessive replacement
Rationale: Excess thyroid hormone can cause manifestations such as
tachycardia, palpitations, tremors, nervousness, heat intolerance, and
insomnia.
9. Prednisone
