ATI PHARM THE IMMUNE SYSTEM EXAM/ATI PHARM-
THE IMMUNE SYSTEM ACTUAL EXAM 2026-2027
COMPLETE EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS WITH RATIONALES (100% RELIABLE
ANSWERS) CURRENTLY UPDATED VERSION EDITION
2026 FULLY REVISED EXAM |GUARANTEED PASS A+
|INSTANT DOWNLOAD PDF
A client is prescribed cyclosporine following a kidney transplant. The nurse should
monitor the client for which adverse effect?
A. Hypertension
B. Nephrotoxicity
C. Hyperkalemia
D. Hepatotoxicity
ANSWER: B
Cyclosporine is a calcineurin inhibitor that is highly nephrotoxic. Monitoring
serum creatinine and BUN is essential to detect early signs of renal impairment.
While hypertension and hepatotoxicity can also occur, nephrotoxicity is the most
common and significant dose-limiting adverse effect.
,A nurse is caring for a client receiving tacrolimus. Which medication, if prescribed
concurrently, would require cautious monitoring due to an increased risk of
nephrotoxicity?
A. Acetaminophen
B. Ibuprofen
C. Diphenhydramine
D. Omeprazole
ANSWER: B
Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can cause renal
vasoconstriction. When combined with tacrolimus, which is already nephrotoxic,
the risk of acute kidney injury is significantly increased. Acetaminophen is
generally safe for use with calcineurin inhibitors.
A client is prescribed azathioprine. The nurse should monitor the client's laboratory
results for which primary adverse effect?
A. Leukopenia
B. Hyperglycemia
C. Thrombocytosis
D. Anemia
ANSWER: A
Azathioprine is a purine synthesis inhibitor that suppresses bone marrow function.
The most significant hematologic effect is leukopenia, which increases the risk of
infection. Monitoring the complete blood count (CBC) is crucial to detect bone
marrow suppression.
,A nurse is teaching a client about mycophenolate mofetil. The client should be
instructed to report which finding immediately?
A. Constipation
B. Insomnia
C. Bruising
D. Nausea
ANSWER: C
Mycophenolate mofetil causes bone marrow suppression, which can lead to
thrombocytopenia. Unexplained bruising or bleeding is a sign of low platelet count
and should be reported immediately. While gastrointestinal effects like nausea are
common, bruising indicates a more serious hematologic adverse effect.
A client is prescribed a monoclonal antibody. The nurse understands that this
medication's mechanism of action is to:
A. Inhibit interleukin-2 production
B. Target specific immune cells for destruction
C. Suppress T-cell proliferation
D. Block the action of tumor necrosis factor
ANSWER: B
Monoclonal antibodies are designed to bind to specific antigens on immune cells,
leading to their destruction. Rituximab, for example, targets CD20 on B cells.
While other immunosuppressants have various mechanisms, the hallmark of
monoclonal antibodies is their targeted destruction of specific cell types.
, A nurse is preparing to administer alemtuzumab. Which assessment finding would
be a contraindication to administering this medication?
A. Mild headache
B. Fever
C. Active infection
D. Fatigue
ANSWER: C
Alemtuzumab causes profound lymphopenia, which severely compromises the
immune system. An active infection is a contraindication because the medication
will worsen the patient's ability to fight the infection. The medication may be
delayed until the infection resolves.
The nurse is caring for a client receiving basiliximab. The nurse understands that
this medication is given primarily to:
A. Treat acute rejection episodes
B. Prevent graft-versus-host disease
C. Provide induction therapy for transplant patients
D. Manage chronic rejection
ANSWER: C
Basiliximab is an interleukin-2 receptor antagonist used as induction therapy to
prevent acute rejection in renal transplant patients. It is given immediately before
and after transplantation. It is not used for acute rejection episodes or graft-versus-
host disease.
THE IMMUNE SYSTEM ACTUAL EXAM 2026-2027
COMPLETE EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS WITH RATIONALES (100% RELIABLE
ANSWERS) CURRENTLY UPDATED VERSION EDITION
2026 FULLY REVISED EXAM |GUARANTEED PASS A+
|INSTANT DOWNLOAD PDF
A client is prescribed cyclosporine following a kidney transplant. The nurse should
monitor the client for which adverse effect?
A. Hypertension
B. Nephrotoxicity
C. Hyperkalemia
D. Hepatotoxicity
ANSWER: B
Cyclosporine is a calcineurin inhibitor that is highly nephrotoxic. Monitoring
serum creatinine and BUN is essential to detect early signs of renal impairment.
While hypertension and hepatotoxicity can also occur, nephrotoxicity is the most
common and significant dose-limiting adverse effect.
,A nurse is caring for a client receiving tacrolimus. Which medication, if prescribed
concurrently, would require cautious monitoring due to an increased risk of
nephrotoxicity?
A. Acetaminophen
B. Ibuprofen
C. Diphenhydramine
D. Omeprazole
ANSWER: B
Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can cause renal
vasoconstriction. When combined with tacrolimus, which is already nephrotoxic,
the risk of acute kidney injury is significantly increased. Acetaminophen is
generally safe for use with calcineurin inhibitors.
A client is prescribed azathioprine. The nurse should monitor the client's laboratory
results for which primary adverse effect?
A. Leukopenia
B. Hyperglycemia
C. Thrombocytosis
D. Anemia
ANSWER: A
Azathioprine is a purine synthesis inhibitor that suppresses bone marrow function.
The most significant hematologic effect is leukopenia, which increases the risk of
infection. Monitoring the complete blood count (CBC) is crucial to detect bone
marrow suppression.
,A nurse is teaching a client about mycophenolate mofetil. The client should be
instructed to report which finding immediately?
A. Constipation
B. Insomnia
C. Bruising
D. Nausea
ANSWER: C
Mycophenolate mofetil causes bone marrow suppression, which can lead to
thrombocytopenia. Unexplained bruising or bleeding is a sign of low platelet count
and should be reported immediately. While gastrointestinal effects like nausea are
common, bruising indicates a more serious hematologic adverse effect.
A client is prescribed a monoclonal antibody. The nurse understands that this
medication's mechanism of action is to:
A. Inhibit interleukin-2 production
B. Target specific immune cells for destruction
C. Suppress T-cell proliferation
D. Block the action of tumor necrosis factor
ANSWER: B
Monoclonal antibodies are designed to bind to specific antigens on immune cells,
leading to their destruction. Rituximab, for example, targets CD20 on B cells.
While other immunosuppressants have various mechanisms, the hallmark of
monoclonal antibodies is their targeted destruction of specific cell types.
, A nurse is preparing to administer alemtuzumab. Which assessment finding would
be a contraindication to administering this medication?
A. Mild headache
B. Fever
C. Active infection
D. Fatigue
ANSWER: C
Alemtuzumab causes profound lymphopenia, which severely compromises the
immune system. An active infection is a contraindication because the medication
will worsen the patient's ability to fight the infection. The medication may be
delayed until the infection resolves.
The nurse is caring for a client receiving basiliximab. The nurse understands that
this medication is given primarily to:
A. Treat acute rejection episodes
B. Prevent graft-versus-host disease
C. Provide induction therapy for transplant patients
D. Manage chronic rejection
ANSWER: C
Basiliximab is an interleukin-2 receptor antagonist used as induction therapy to
prevent acute rejection in renal transplant patients. It is given immediately before
and after transplantation. It is not used for acute rejection episodes or graft-versus-
host disease.
