NR 546 Advanced Psychopharmacology - Final Exam 2026 Page 1
NR 546: Advanced Psychopharmacology
Final Exam Actual Questions & Verified Answers
2 FULL EXAM SETS • 2026 EDITION • GUARANTEE PASS
Comprehensive Management of Neurotransmitters and Psychotropic Agents
Chamberlain College of Nursing | Professional PMHNP Series
FINAL EXAM SET 1: ADVANCED PSYCHOPHARMACOLOGY
Q1 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
,NR 546 Advanced Psychopharmacology - Final Exam 2026 Page 2
Q2 (Set 1)
A patient taking Lamotrigine (Lamictal) for mood stabilization develops a new,
blistering rash and fever. What is the priority intervention?
A) Reduce the dose by half
B) Monitor for 24 hours
C) Immediate discontinuation and ER referral
D) Add an antihistamine
Correct
C) Immediate discontinuation and ER referral
Rationale
Lamotrigine carries a Black Box Warning for Stevens-Johnson Syndrome (SJS). Any
new rash in a patient starting Lamotrigine must be treated as a medical emergency.
Q3 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
,NR 546 Advanced Psychopharmacology - Final Exam 2026 Page 3
Q4 (Set 1)
A patient taking Lamotrigine (Lamictal) for mood stabilization develops a new,
blistering rash and fever. What is the priority intervention?
A) Reduce the dose by half
B) Monitor for 24 hours
C) Immediate discontinuation and ER referral
D) Add an antihistamine
Correct
C) Immediate discontinuation and ER referral
Rationale
Lamotrigine carries a Black Box Warning for Stevens-Johnson Syndrome (SJS). Any
new rash in a patient starting Lamotrigine must be treated as a medical emergency.
Q5 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
, NR 546 Advanced Psychopharmacology - Final Exam 2026 Page 4
Q6 (Set 1)
A patient taking Lamotrigine (Lamictal) for mood stabilization develops a new,
blistering rash and fever. What is the priority intervention?
A) Reduce the dose by half
B) Monitor for 24 hours
C) Immediate discontinuation and ER referral
D) Add an antihistamine
Correct
C) Immediate discontinuation and ER referral
Rationale
Lamotrigine carries a Black Box Warning for Stevens-Johnson Syndrome (SJS). Any
new rash in a patient starting Lamotrigine must be treated as a medical emergency.
Q7 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
NR 546: Advanced Psychopharmacology
Final Exam Actual Questions & Verified Answers
2 FULL EXAM SETS • 2026 EDITION • GUARANTEE PASS
Comprehensive Management of Neurotransmitters and Psychotropic Agents
Chamberlain College of Nursing | Professional PMHNP Series
FINAL EXAM SET 1: ADVANCED PSYCHOPHARMACOLOGY
Q1 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
,NR 546 Advanced Psychopharmacology - Final Exam 2026 Page 2
Q2 (Set 1)
A patient taking Lamotrigine (Lamictal) for mood stabilization develops a new,
blistering rash and fever. What is the priority intervention?
A) Reduce the dose by half
B) Monitor for 24 hours
C) Immediate discontinuation and ER referral
D) Add an antihistamine
Correct
C) Immediate discontinuation and ER referral
Rationale
Lamotrigine carries a Black Box Warning for Stevens-Johnson Syndrome (SJS). Any
new rash in a patient starting Lamotrigine must be treated as a medical emergency.
Q3 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
,NR 546 Advanced Psychopharmacology - Final Exam 2026 Page 3
Q4 (Set 1)
A patient taking Lamotrigine (Lamictal) for mood stabilization develops a new,
blistering rash and fever. What is the priority intervention?
A) Reduce the dose by half
B) Monitor for 24 hours
C) Immediate discontinuation and ER referral
D) Add an antihistamine
Correct
C) Immediate discontinuation and ER referral
Rationale
Lamotrigine carries a Black Box Warning for Stevens-Johnson Syndrome (SJS). Any
new rash in a patient starting Lamotrigine must be treated as a medical emergency.
Q5 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
, NR 546 Advanced Psychopharmacology - Final Exam 2026 Page 4
Q6 (Set 1)
A patient taking Lamotrigine (Lamictal) for mood stabilization develops a new,
blistering rash and fever. What is the priority intervention?
A) Reduce the dose by half
B) Monitor for 24 hours
C) Immediate discontinuation and ER referral
D) Add an antihistamine
Correct
C) Immediate discontinuation and ER referral
Rationale
Lamotrigine carries a Black Box Warning for Stevens-Johnson Syndrome (SJS). Any
new rash in a patient starting Lamotrigine must be treated as a medical emergency.
Q7 (Set 1)
Which neurotransmitter is primarily targeted by First-Generation Antipsychotics
(FGAs) to reduce positive symptoms of schizophrenia?
A) Serotonin (5HT2A) Antagonism
B) Dopamine (D2) Antagonism
C) Norepinephrine Reuptake Inhibition
D) GABA Agonism
Correct
B) Dopamine (D2) Antagonism
Rationale
FGAs (Typical antipsychotics) work by blocking D2 receptors in the mesolimbic
pathway, which reduces positive symptoms like hallucinations. However, they also
block D2 in the nigrostriatal pathway, leading to EPS.
PMHNP Clinical Mastery | Chamberlain NR 546
