CRCM BSA AML FRAUD DETECTION
REPORTING REQUIREMENTS SAR CTR
FILING PROCEDURES PRACTICE TEST
PAPER
●● What is required for the diagnosis of ALL/AML?
Answer: bone marrow biopsy
●● What are some poor prognosis risk factors for ALL?
Answer: - Philadelphia chromosome
- age <1 or >10 years old
- t(4:11)
- TP53
- monosomy of chromosome 7
●● What defines remission in ALL?
Answer: continuous complete response for >5 years
●● What ALL patients will receive CNS prophylaxis?
Answer: all of the patients will get it
, ●● What are the options for CNS therapy for ALL?
Answer: - cranial irradiation
- intrathecal therapy (MTX, cytarabine, corticosteroid)**
- high dose systemic chemotherapy
●● What is the backbone of induction therapy for ALL?
Answer: - vincristine
- cyclophosphamide
- anthracycline
- steroids
●● What chemotherapy agent should never be given intrathecally
because it can be fatal (always dispensed in IV minibag)?
Answer: vincristine
●● What are the common ADE associated with vincristine?
Answer: - neurotoxicity
- neuropathy
- extravasation (warm compress)
●● What are the toxicities associated with cyclophosphamide?
Answer: - myelosuppression
REPORTING REQUIREMENTS SAR CTR
FILING PROCEDURES PRACTICE TEST
PAPER
●● What is required for the diagnosis of ALL/AML?
Answer: bone marrow biopsy
●● What are some poor prognosis risk factors for ALL?
Answer: - Philadelphia chromosome
- age <1 or >10 years old
- t(4:11)
- TP53
- monosomy of chromosome 7
●● What defines remission in ALL?
Answer: continuous complete response for >5 years
●● What ALL patients will receive CNS prophylaxis?
Answer: all of the patients will get it
, ●● What are the options for CNS therapy for ALL?
Answer: - cranial irradiation
- intrathecal therapy (MTX, cytarabine, corticosteroid)**
- high dose systemic chemotherapy
●● What is the backbone of induction therapy for ALL?
Answer: - vincristine
- cyclophosphamide
- anthracycline
- steroids
●● What chemotherapy agent should never be given intrathecally
because it can be fatal (always dispensed in IV minibag)?
Answer: vincristine
●● What are the common ADE associated with vincristine?
Answer: - neurotoxicity
- neuropathy
- extravasation (warm compress)
●● What are the toxicities associated with cyclophosphamide?
Answer: - myelosuppression
