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Thyroid stimulating hormone, which is a glycoprotein syn-
What controls thyroid gland function?
thesized in the anterior pituitary gland
When are TSH levels the highest? during sleep
The body can sense a decrease in T3 levels, and sends
a signal to the brain. The hypothalamus receives the sig-
nal, and makes TRH (thyrotropin releasing hormone). TRH
Explain the process of how T3 is produced then travels to the anterior pituitary, and signals TSH (thy-
roid stimulating hormone) to be made. TSH then travels
to the thyroid and tells the thyroid to produce more T4,
which is converted to T3 in peripheral sites in the body
How is thyroid hormone transported in the body? Thyroxine binding globulin (TBG)
are bound or unbound hormones active? unbound to plasma proteins (the free hormones)
Is T3 or T4 more active? T3 is 4x more active than T4
energy, heat production, growth, facilitate CNS, metabo-
What do thyroid hormones regulate?
lism
What is primary thyroid dysfunction? when the dysfunction occurs and the gland itself
What is secondary thyroid dysfunction? When the dysfunction occurs are the pituitary gland
What is tertiary thyroid dysfunction? When the dysfunction occurs at the hypothalamus
What is the most common cause of thyroid disease? autoimmune disease
reduction in amount of circulating free thyroid hormone
What is hypothyroidism?
(T4)
family history, females, other autoimmune diseases, treat-
What are risk factors for hypothyroidism? ment for hyperthyroidism, amiodarone, lithium, age over
40
How often should females over 40 get TSH checked? annually
What are the s/s of hypothyroidism?
, lethargy, weight gain, swelling of hands and feet, perior-
bital edema, coarse skin, hair loss, delayed deep tendon
reflexes, constipation, hyperlipidemia
TSH, wise to get a lipid panel due to hyperlipidemia it
What testing is needed for hypothyroidism?
causes
TSH will be high, T4 will be low
How do you interpret TSH levels for hypothyroid?
subclinical hypothyroid will have elevated TSH and normal
T4
baby cannot produce their own thyroid hormone until
2nd trimester...so if mom has a hypothyroid, the baby will
What is the ettect of maternal hypothyroid in a pregnant
definitely not get enough thyroid. Moms usually need to
woman?
increase their dosage for thyroid medications by 50% until
about week 16 of pregnancy
neuropsychological deficits, derangement of growth,
What are some ettects of inadequate thyroid for fetus? large and protruding tongue, potbelly, dwarsh stature,
mental delays
Treat with levothyroxine for 3 years, then stop for 4 weeks.
Check the TSH, and if the TSH is elevated, it tells you the
body is not adequately making thyroid hormone, and the
How do you treat a child with congenital hypothyroidism?
hypothyroidism is permanent. if the TSH is normal and so
is the T4, the deficiency was transient and you no longer
need to be treating with levothyroxine
25-50mcg PO daily of levothyroxine and monitor every 3
How do you treat subclinical hypothyroid? months. Treatment is controversial, but most patients with
subclinical usually do develop hypothyroidism
What does levothyroxine do? replaces T4 (thyroxine)
What does armour thryoid do? replaces T3 only. Harder to regulate
What does liothyronine do? Replaces T3 only.
What does Liotrix do?