AOCNP Test Review Latest recent and
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questions and verified accurate solution
(detailed & elaborated) GRADED A+
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,Treatments that place individuals at increased risk for infection - correct ans:Chemotherapy treatments
including high-dose cyclophosphamide, doxorubicin, docetaxel, or alemtuzumab.
Colony stimulating factors (CSF) - correct ans:**GM-CSF : growth factor for hematopoietic stem cells and
granulocyte/monocytes
**M-CSF (macrophage): essential for macrophage production
**G-CSF (granulocyte) :essential for neutrophils
**Erythropoietin (EPO): growth factor for RBC
Filgrastim (Neupogen)
Pegfilgrastim (Neulasta)
Tbo-filgrastim (Granix) - correct ans:Common side effects: mild to moderate bone pain
Used to patients at risk of experiencing treatment induced neutropenia
Major benefit: reducing the possibility of myelosuppression and permitting the continuation of
therapeutic chemotherapy doses
Filgrastim (Neupogen) - correct ans:Dose: 5 µg per kilogram per day. Begin 24 to 72 hours after
completion of chemotherapy and continue through the post nadir period.
Pegfilgrastim (Neulasta) - correct ans:That was: 6 mg per cycle. Again 1 to 3 days post chemotherapy.
Administer as a single 6 mg injection once per cycle. Do not administer in the period beginning 14 days
before until 24 hours after administration of chemotherapy.
Antimicrobial prophylaxis for infection - correct ans:Low risk: no prophylaxis Recommended unless the
patient has prior herpes simplex virus episode.
Intermediate risk:
Bacterial: consider Fluoroquinolone
Fungal: consider fluconazole during neutropenia and if mucositis is anticipated
Viral: during neutropenia and at least 30 days after transplantation
,High risk:
Bacterial: consider fluoroquinolone
Fungal: consider fluconazole or other anti-fungal agent
Viral: during neutropenia and at least 30 days after transplantation
Graft versus host disease: penicillin andtrimethroprim/sulfamethoxazole (tmp/smx) Or equivalent for
allogenic heamatopoetic Stem cell transplant recipients
Alemtuzumab: TMP/SMX
Complete diagnostic work up for neutropenic fever - correct ans:Blood cultures: bacterial, viral, and
fungal
BUN, electrolytes, and creatinine
Chest x-ray
CBC and differential
Liver function test
Pulse oximetry
Site-specific cytology and cultures
Urinanalysis
ANC calculation - correct ans:WBC x [(% segs + % bands)/100]
aplastic anemia - correct ans:a normocytic-normochromic type of anemia characterized by the failure of
bone marrow to produce red blood cells
hemolytic anemia - correct ans:characterized by an inadequate number of circulating red blood cells due
to the premature destruction of red blood cells by the spleen
deficiency anemia - correct ans:anemia caused by lack of necessary nutrients
B12, folate, and iron
, Anemia # of RBC/ MCV - correct ans:Microcytic. Normocytic. Macrocyctic.
Microcytic anemia with ↓ serum iron, ↓ total iron-binding capacity (TIBC), and normal or ↑ ferritin. -
correct ans:cells smaller than normal
Iron deficiency
macrocytic anemia - correct ans:due to folate or vitamin B12(cobalamin) deficiency (megaloblastic
anemia), THF-M --> VitB12-M --> Methionine, (transfer of methyl groups)
erythrpoietin (EPO) - correct ans:Stimulates development of RBC production
Triggered to release by reduced oxygen level of RBC mass trigger from the kidney
Labs to check in anemia - correct ans:CBC with diff
Peripheral smear
Reticulocyte count
Iron studies: serum iron, total iron binding capacity, ferritin
Vitamin B 12
Full eight red cell
If these are not diagnostic these may be added
Fractionated Bilirubin
Occult stool
Coombs test
Haptoglobin level
Hemoglobin electrophoresis
Bone marrow biopsy
frequently tested exam with comprehensive
questions and verified accurate solution
(detailed & elaborated) GRADED A+
Professional Academic Assistance Services
Services Offered
Proctored Exam Assistance
Online Class Management (Full Course Support)
Exam Preparation & Study Materials
Assignments and Coursework Support
Essays and Research Papers
Discussion Posts and Replies
CONTACT INFORMATION
WHATAPPSLINK- https://wa.me/254784769540
,Treatments that place individuals at increased risk for infection - correct ans:Chemotherapy treatments
including high-dose cyclophosphamide, doxorubicin, docetaxel, or alemtuzumab.
Colony stimulating factors (CSF) - correct ans:**GM-CSF : growth factor for hematopoietic stem cells and
granulocyte/monocytes
**M-CSF (macrophage): essential for macrophage production
**G-CSF (granulocyte) :essential for neutrophils
**Erythropoietin (EPO): growth factor for RBC
Filgrastim (Neupogen)
Pegfilgrastim (Neulasta)
Tbo-filgrastim (Granix) - correct ans:Common side effects: mild to moderate bone pain
Used to patients at risk of experiencing treatment induced neutropenia
Major benefit: reducing the possibility of myelosuppression and permitting the continuation of
therapeutic chemotherapy doses
Filgrastim (Neupogen) - correct ans:Dose: 5 µg per kilogram per day. Begin 24 to 72 hours after
completion of chemotherapy and continue through the post nadir period.
Pegfilgrastim (Neulasta) - correct ans:That was: 6 mg per cycle. Again 1 to 3 days post chemotherapy.
Administer as a single 6 mg injection once per cycle. Do not administer in the period beginning 14 days
before until 24 hours after administration of chemotherapy.
Antimicrobial prophylaxis for infection - correct ans:Low risk: no prophylaxis Recommended unless the
patient has prior herpes simplex virus episode.
Intermediate risk:
Bacterial: consider Fluoroquinolone
Fungal: consider fluconazole during neutropenia and if mucositis is anticipated
Viral: during neutropenia and at least 30 days after transplantation
,High risk:
Bacterial: consider fluoroquinolone
Fungal: consider fluconazole or other anti-fungal agent
Viral: during neutropenia and at least 30 days after transplantation
Graft versus host disease: penicillin andtrimethroprim/sulfamethoxazole (tmp/smx) Or equivalent for
allogenic heamatopoetic Stem cell transplant recipients
Alemtuzumab: TMP/SMX
Complete diagnostic work up for neutropenic fever - correct ans:Blood cultures: bacterial, viral, and
fungal
BUN, electrolytes, and creatinine
Chest x-ray
CBC and differential
Liver function test
Pulse oximetry
Site-specific cytology and cultures
Urinanalysis
ANC calculation - correct ans:WBC x [(% segs + % bands)/100]
aplastic anemia - correct ans:a normocytic-normochromic type of anemia characterized by the failure of
bone marrow to produce red blood cells
hemolytic anemia - correct ans:characterized by an inadequate number of circulating red blood cells due
to the premature destruction of red blood cells by the spleen
deficiency anemia - correct ans:anemia caused by lack of necessary nutrients
B12, folate, and iron
, Anemia # of RBC/ MCV - correct ans:Microcytic. Normocytic. Macrocyctic.
Microcytic anemia with ↓ serum iron, ↓ total iron-binding capacity (TIBC), and normal or ↑ ferritin. -
correct ans:cells smaller than normal
Iron deficiency
macrocytic anemia - correct ans:due to folate or vitamin B12(cobalamin) deficiency (megaloblastic
anemia), THF-M --> VitB12-M --> Methionine, (transfer of methyl groups)
erythrpoietin (EPO) - correct ans:Stimulates development of RBC production
Triggered to release by reduced oxygen level of RBC mass trigger from the kidney
Labs to check in anemia - correct ans:CBC with diff
Peripheral smear
Reticulocyte count
Iron studies: serum iron, total iron binding capacity, ferritin
Vitamin B 12
Full eight red cell
If these are not diagnostic these may be added
Fractionated Bilirubin
Occult stool
Coombs test
Haptoglobin level
Hemoglobin electrophoresis
Bone marrow biopsy
