CMN 548 ACTUAL CERTIFICATION
PAPER 2026 QUESTIONS WITH ANSWERS
FULL SOLUTION.
◍ Black Box Warning. Ans: This warning reflects that a medication may
cause a serious or even life-threatening side effect
◍ Partial or Mixed Agonist. Ans: A compound that elicits a partial
pharmacological response at the receptor site involved
◍ Remission. Ans: The degree of improvement to below the syndromal
threshold of a disorder
◍ Paradoxical. Ans: A response to a drug that represents the clinical
effect opposite of what is expected
◍ Inverse agonist. Ans: An agent that binds to the same receptor site as
an agonist but produces the opposite pharmacological effect
◍ 4 major transmitters. Ans: Dopamine, Serotonin, GABA,
Norepinephrine
,◍ Dopamine transmitter affects?. Ans: affects mood, Psychosis, ADHD,
Addiction
◍ Serotonin transmitter affects?. Ans: Depression, aggression, OCD,
Panic, GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction,
substance addiction
◍ Norepinephrine affects?. Ans: Affects mood, anxiety, psychosis,
ADHD (part), drug withdrawal
◍ GABA affects?. Ans: Fear, anxiety, worry
◍ Irreversible MAOIs Types. Ans: MAOa and MAOb
◍ Irreversible MAOIs medications. Ans: Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
◍ A single dose of MAOIs may persist in its inhibition of MAO for how
long?. Ans: because they irreversibly inactivate MAOs, the therapeutic
effect of a single dose of irreversible MAOIs may persist for as long as 2
weeks
,◍ What are the most frequent adverse effects of MAOIs?. Ans:
orthostatic hypotension, insomnia, weight gain, edema, sexual
dysfunction
◍ Reversible MAOIs (RIMAs) medications?. Ans: Moclobemide
(Maerix)
◍ How long will it take to recover MAO activity after a final dose of
RIMA?. Ans: MAO activity recovers completely 24-48 hrs after the last
dose of a RIMA
◍ MAOIs are used to treat what conditions?. Ans: depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
, ◍ Treatment for MAOI induced orthostatic hypotension?. Ans: Avoid
caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
◍ How long should the NP wait to begin another tx for depression when
stopping an MAOI to begin another MAOI or SSRI?. Ans: irreversible
MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
◍ How long should the NP wait to begin an MAOI after d/c a pt from
fluoxetine (Prozac)?. Ans: when switching from an antidepressant to an
irreversible MAOI-should wait 10-14 days (or 5 weeks for fluoxetine
(Prozac) before starting use of MAOI to avoid drug interactions
◍ Complications for using MAOIs for pts who have bipolar I and
schizophrenia?. Ans: induction of mania in the depressed phase of
bipolar I disorder and triggering of a psychotic decompensation in
persons with schizophrenia
◍ Symptoms of tyramine-induced hypertensive crisis?. Ans: Severe
HTN
PAPER 2026 QUESTIONS WITH ANSWERS
FULL SOLUTION.
◍ Black Box Warning. Ans: This warning reflects that a medication may
cause a serious or even life-threatening side effect
◍ Partial or Mixed Agonist. Ans: A compound that elicits a partial
pharmacological response at the receptor site involved
◍ Remission. Ans: The degree of improvement to below the syndromal
threshold of a disorder
◍ Paradoxical. Ans: A response to a drug that represents the clinical
effect opposite of what is expected
◍ Inverse agonist. Ans: An agent that binds to the same receptor site as
an agonist but produces the opposite pharmacological effect
◍ 4 major transmitters. Ans: Dopamine, Serotonin, GABA,
Norepinephrine
,◍ Dopamine transmitter affects?. Ans: affects mood, Psychosis, ADHD,
Addiction
◍ Serotonin transmitter affects?. Ans: Depression, aggression, OCD,
Panic, GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction,
substance addiction
◍ Norepinephrine affects?. Ans: Affects mood, anxiety, psychosis,
ADHD (part), drug withdrawal
◍ GABA affects?. Ans: Fear, anxiety, worry
◍ Irreversible MAOIs Types. Ans: MAOa and MAOb
◍ Irreversible MAOIs medications. Ans: Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
◍ A single dose of MAOIs may persist in its inhibition of MAO for how
long?. Ans: because they irreversibly inactivate MAOs, the therapeutic
effect of a single dose of irreversible MAOIs may persist for as long as 2
weeks
,◍ What are the most frequent adverse effects of MAOIs?. Ans:
orthostatic hypotension, insomnia, weight gain, edema, sexual
dysfunction
◍ Reversible MAOIs (RIMAs) medications?. Ans: Moclobemide
(Maerix)
◍ How long will it take to recover MAO activity after a final dose of
RIMA?. Ans: MAO activity recovers completely 24-48 hrs after the last
dose of a RIMA
◍ MAOIs are used to treat what conditions?. Ans: depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
, ◍ Treatment for MAOI induced orthostatic hypotension?. Ans: Avoid
caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
◍ How long should the NP wait to begin another tx for depression when
stopping an MAOI to begin another MAOI or SSRI?. Ans: irreversible
MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
◍ How long should the NP wait to begin an MAOI after d/c a pt from
fluoxetine (Prozac)?. Ans: when switching from an antidepressant to an
irreversible MAOI-should wait 10-14 days (or 5 weeks for fluoxetine
(Prozac) before starting use of MAOI to avoid drug interactions
◍ Complications for using MAOIs for pts who have bipolar I and
schizophrenia?. Ans: induction of mania in the depressed phase of
bipolar I disorder and triggering of a psychotic decompensation in
persons with schizophrenia
◍ Symptoms of tyramine-induced hypertensive crisis?. Ans: Severe
HTN
