UAMS_HEME_LAB_PRACTICAL_3_COMPREHENSIVE_EXAM_2026_QUESTIONS_AND.pdf

UAMS HEME LAB PRACTICAL 3
COMPREHENSIVE EXAM
QUESTIONS AND ANSWERS
GRADED A PLUS
◉ if VIII:vWF is deficient. Answer: Von Willebrand Disease
Factor VIII:C is also deficient, prolonged PTT


◉ What does VIII:vWF do. Answer: attaches collagen to glycoprotein
IB on platelet surface


◉ Difference between Hemophilia A and vWD. Answer: Hemophilia
A has normal bleeding time, Rist agg, vWFR:Co, and vWF:Ag


vWD is abnormal for all


◉ how is Hemophilia A inherited. Answer: recessive, X-linked


◉ How is vWD inherited. Answer: dominant, autosomal


◉ Platelet agg studies measure. Answer: primary and secondary
aggregation with various aggregates such as ADP

, ◉ What does an abnormal aggregation graph indicate. Answer:
platelet membrane defect
aspirin use
storage pool defect


◉ What agonist with an abnormal aggregation indicates vWD.
Answer: ristocetin


◉ Bernard Soulier disease. Answer: GPIb/IX/V complex is missing
on plt surface


◉ abnormal plt agg with bernard soulier disease. Answer: ristocetin
ristocetin and vWF


◉ Glanzmanns thrombasthenia. Answer: Defective plt membrane GP
IIb/IIIa


◉ abnormal plt agg with Glanzmanns. Answer: unable to find
fibrinogen
ADP
Collagen
Epinephrine